دورية أكاديمية
CCR4 expression on host T cells is a driver for alloreactive responses and lung rejection.
| العنوان: | CCR4 expression on host T cells is a driver for alloreactive responses and lung rejection. |
|---|---|
| المؤلفون: | Palchevskiy V; Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA., Xue YY; Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA., Kern R; Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA., Weigt SS; Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA., Gregson AL; Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA., Song SX; Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA., Fishbein MC; Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA., Hogaboam CM; Pulmonary & Critical Care Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA., Sayah DM; Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA., Lynch JP 3rd; Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA., Keane MP; University College Dublin School of Medicine, Respiratory Medicine, St Vincent's University Hospital, Dublin, Ireland., Brooks DG; Princess Margaret Cancer Center, University Health Network and Department of Immunology, University of Toronto, Toronto, Ontario, Canada., Belperio JA; Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA. |
| المصدر: | JCI insight [JCI Insight] 2019 May 14; Vol. 5. Date of Electronic Publication: 2019 May 14. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Ann Arbor, Michigan : American Society for Clinical Investigation, [2016]- |
| مواضيع طبية MeSH: | Graft Rejection/*immunology , Lung Transplantation/*adverse effects , Receptors, CCR4/*metabolism , T-Lymphocytes/*immunology, Adoptive Transfer ; Allografts/immunology ; Allografts/pathology ; Animals ; Disease Models, Animal ; Female ; Graft Rejection/pathology ; Graft Survival/immunology ; Humans ; Lung/immunology ; Lung/pathology ; Mice ; Mice, Knockout ; Proof of Concept Study ; Receptors, CCR4/genetics ; Receptors, CCR4/immunology ; Signal Transduction/genetics ; Signal Transduction/immunology ; T-Lymphocytes/metabolism ; T-Lymphocytes/transplantation ; Transplantation, Homologous/adverse effects |
| مستخلص: | Despite current immunosuppressive strategies, long-term lung transplant outcomes remain poor due to rapid allogenic responses. Using a stringent mouse model of allo-airway transplantation, we identify the CCR4-ligand axis as a central node driving secondary lymphoid tissue homing and activation of the allogeneic T cells that prevent long-term allograft survival. CCR4 deficiency on transplant recipient T cells diminishes allograft injury and when combined with CTLA4-Ig leads to an unprecedented long-term lung allograft accommodation. Thus, we identify CCR4-ligand interactions as a central mechanism driving allogeneic transplant rejection and suggest it as a potential target to enhance long-term lung transplant survival. |
| References: | JCI Insight. 2017 May 4;2(9):. (PMID: 28469087) J Heart Lung Transplant. 2007 Dec;26(12):1229-42. (PMID: 18096473) J Immunol. 2002 Jul 15;169(2):1037-49. (PMID: 12097412) J Immunol. 2000 Jul 1;165(1):461-72. (PMID: 10861085) Cancer Res. 2016 Oct 1;76(19):5671-5682. (PMID: 27530322) Am J Transplant. 2017 May;17(5):1294-1303. (PMID: 27676455) Fibrogenesis Tissue Repair. 2011 Apr 04;4:10. (PMID: 21463523) Hum Immunol. 2005 Nov;66(11):1110-24. (PMID: 16571412) Nat Immunol. 2003 Jun;4(6):579-85. (PMID: 12730692) J Immunol. 2005 Nov 15;175(10):6931-9. (PMID: 16272353) J Immunol. 2007 Mar 1;178(5):2973-8. (PMID: 17312142) Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2604-9. (PMID: 12601158) J Exp Med. 2005 Apr 4;201(7):1037-44. (PMID: 15809349) J Exp Med. 2015 Oct 19;212(11):1947-65. (PMID: 26417005) Transpl Immunol. 1998 Mar;6(1):1-11. (PMID: 9640623) Semin Respir Crit Care Med. 2010 Apr;31(2):189-207. (PMID: 20354932) Nature. 2004 Jan 8;427(6970):154-9. (PMID: 14712275) Braz J Med Biol Res. 2002 Nov;35(11):1247-58. (PMID: 12426623) Nat Immunol. 2006 Jun;7(6):652-62. (PMID: 16633346) Semin Respir Crit Care Med. 2013 Jun;34(3):336-51. (PMID: 23821508) Proc Natl Acad Sci U S A. 2004 Jan 27;101(4):998-1003. (PMID: 14722354) Proc Am Thorac Soc. 2009 Jan 15;6(1):108-21. (PMID: 19131536) Mod Pathol. 2013 Mar;26(3):350-6. (PMID: 23018877) JAMA Surg. 2015 Mar 1;150(3):252-9. (PMID: 25629390) Invest Ophthalmol Vis Sci. 1987 Mar;28(3):565-70. (PMID: 3030956) Immunol Rev. 2006 Feb;209:115-28. (PMID: 16448538) Transplant Rev (Orlando). 2012 Jul;26(3):212-22. (PMID: 22074786) J Exp Med. 1992 Aug 1;176(2):553-64. (PMID: 1386876) Int Immunol. 2000 Sep;12(9):1285-92. (PMID: 10967023) Immunity. 2006 Dec;25(6):989-1001. (PMID: 17112751) J Invest Dermatol. 1999 Dec;113(6):991-8. (PMID: 10594742) Immunity. 2009 Mar 20;30(3):458-69. (PMID: 19303390) Am J Transplant. 2011 Jun;11(6):1226-35. (PMID: 21564524) Nature. 2006 Apr 13;440(7086):890-5. (PMID: 16612374) Am J Transplant. 2018 Jan;18 Suppl 1:172-253. (PMID: 29292603) Am J Pathol. 2011 Apr;178(4):1635-45. (PMID: 21435448) J Immunol. 2007 Jun 15;178(12):7747-55. (PMID: 17548612) J Clin Invest. 2001 Aug;108(4):547-56. (PMID: 11518728) Science. 2002 Jun 7;296(5574):1869-73. (PMID: 12016203) J Immunol. 2007 Jan 1;178(1):511-9. (PMID: 17182591) Semin Immunol. 2003 Oct;15(5):257-70. (PMID: 15001175) J Clin Invest. 2005 May;115(5):1150-62. (PMID: 15864347) J Invest Dermatol. 2009 Apr;129(4):879-90. (PMID: 19005490) Hepatology. 1991 May;13(5):882-91. (PMID: 2029992) Nat Immunol. 2010 Apr;11(4):313-20. (PMID: 20190758) J Exp Med. 2009 Apr 13;206(4):751-60. (PMID: 19332874) J Heart Lung Transplant. 2017 Oct;36(10):1047-1059. (PMID: 28784324) PLoS One. 2017 Jan 19;12(1):e0169894. (PMID: 28103284) Am J Respir Crit Care Med. 2013 Nov 1;188(9):1117-25. (PMID: 24063316) Transplantation. 2018 Jun;102(6):986-993. (PMID: 29256975) Nat Immunol. 2007 Sep;8(9):921-30. (PMID: 17660821) Methods. 2001 Dec;25(4):402-8. (PMID: 11846609) Nat Immunol. 2004 Dec;5(12):1243-50. (PMID: 15543150) Transplantation. 2001 Feb 15;71(3):491. (PMID: 11233918) J Heart Lung Transplant. 2016 Oct;35(10):1170-1184. (PMID: 27772669) J Exp Med. 1990 Jan 1;171(1):307-14. (PMID: 2404081) Am J Transplant. 2018 Jan;18 Suppl 1:18-113. (PMID: 29292608) Proc Natl Acad Sci U S A. 2005 May 31;102(22):7916-21. (PMID: 15905333) Eur J Immunol. 2005 Jan;35(1):128-38. (PMID: 15593118) J Allergy Clin Immunol. 1999 Feb;103(2 Pt 1):192-9. (PMID: 9949307) Transplantation. 1995 Feb 15;59(3):313-8. (PMID: 7871557) Nat Med. 2000 Feb;6(2):114. (PMID: 10655073) Semin Respir Crit Care Med. 2003 Oct;24(5):499-530. (PMID: 16088570) Cold Spring Harb Perspect Med. 2014 Jan 01;4(1):a015529. (PMID: 24384815) |
| معلومات مُعتمدة: | P01 HL108793 United States HL NHLBI NIH HHS; R01 HL112990 United States HL NHLBI NIH HHS |
| فهرسة مساهمة: | Keywords: Adaptive immunity; Chemokines; Immunology; T cells; Transplantation |
| المشرفين على المادة: | 0 (Ccr4 protein, mouse) 0 (Receptors, CCR4) |
| تواريخ الأحداث: | Date Created: 20190516 Date Completed: 20200924 Latest Revision: 20240718 |
| رمز التحديث: | 20240718 |
| مُعرف محوري في PubMed: | PMC6629140 |
| DOI: | 10.1172/jci.insight.121782 |
| PMID: | 31085832 |
| قاعدة البيانات: | MEDLINE |
كن أول من يترك تعليقا!