دورية أكاديمية
Association of Ebola Virus Infection With Hearing Loss in Regions Where Ebola Virus Infection Is Endemic: A Systematic Review.
| العنوان: | Association of Ebola Virus Infection With Hearing Loss in Regions Where Ebola Virus Infection Is Endemic: A Systematic Review. |
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| المؤلفون: | Xu MJ; Department of Otolaryngology-Head and Neck Surgery, University of California San Francisco, San Francisco., Stanford-Moore G; Department of Otolaryngology-Head and Neck Surgery, University of California San Francisco, San Francisco., Czechowicz JA; Department of Otolaryngology-Head and Neck Surgery, University of California San Francisco, San Francisco. |
| المصدر: | JAMA otolaryngology-- head & neck surgery [JAMA Otolaryngol Head Neck Surg] 2019 Jul 01; Vol. 145 (7), pp. 669-675. |
| نوع المنشور: | Journal Article; Meta-Analysis; Systematic Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Medical Association Country of Publication: United States NLM ID: 101589542 Publication Model: Print Cited Medium: Internet ISSN: 2168-619X (Electronic) Linking ISSN: 21686181 NLM ISO Abbreviation: JAMA Otolaryngol Head Neck Surg Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Chicago, IL : American Medical Association, [2013]- |
| مواضيع طبية MeSH: | Hearing Loss/*virology , Hemorrhagic Fever, Ebola/*complications, Adolescent ; Adult ; Africa/epidemiology ; Aged ; Audiometry, Pure-Tone ; Case-Control Studies ; Child ; Child, Preschool ; Cross-Sectional Studies ; Endemic Diseases ; Female ; Hemorrhagic Fever, Ebola/epidemiology ; Humans ; Infant ; Male ; Middle Aged ; Survivors ; Young Adult |
| مستخلص: | Importance: Many survivors of Ebola virus infection describe new-onset hearing loss after infection. The prevalence, severity, and pathophysiologic features of hearing loss in this population have not been well characterized. Objective: To perform a systematic review of the current literature to characterize hearing loss in survivors of Ebola virus infection. Evidence Review: This study adhered to the relevant sections of the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guideline. Searches through PubMed, Embase, and Google Scholar were performed to include publications written in English from January 1, 1965, to October 1, 2018. Relevant vocabulary terms and key terms related to Ebola and hearing loss were used. Two investigators independently screened the eligible studies, extracted data, and assessed quality and risk of bias. Findings: Of 127 publications reviewed, 15 met the criteria for inclusion; 3 were retrospective case-control studies (level of evidence, 3), and 12 were cross-sectional studies or case reports (level of evidence, 4). Studies included 1775 survivors of Ebola virus infection (993 female [55.9%]) and 363 uninfected controls (186 female [51.2%]) from the Democratic Republic of the Congo, Uganda, Guinea, Liberia, and Sierra Leone. The duration of follow-up ranged from 0 to 29 months (median, 5 months). Hearing loss was reported in 147 survivors of Ebola virus infection (8.3%). Among studies that compared survivors with controls, the reported odds ratios for hearing loss in survivors was 7.50 (95% CI, 3.91-14.39; range, 1.4-12.1). Including all studies, the odds ratio of hearing loss in survivors vs controls in countries where Ebola virus infection is endemic was 1.84 (95% CI, 1.10-3.08). Conclusions and Relevance: Survivors of Ebola virus infection had higher rates of hearing loss than uninfected controls in regions where the infection is endemic. Further research with consistent objective methods and pure-tone audiometry may be needed to better characterize the hearing loss, understand its pathophysiologic features, and develop treatments. |
| تواريخ الأحداث: | Date Created: 20190517 Date Completed: 20200612 Latest Revision: 20200612 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1001/jamaoto.2019.0710 |
| PMID: | 31095264 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2168-619X |
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| DOI: | 10.1001/jamaoto.2019.0710 |