دورية أكاديمية
Comparative disposition of dimethylaminoethanol and choline in rats and mice following oral or intravenous administration.
العنوان: | Comparative disposition of dimethylaminoethanol and choline in rats and mice following oral or intravenous administration. |
---|---|
المؤلفون: | Shipkowski KA; Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States of America., Sanders JM; Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States of America., McDonald JD; Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, United States of America., Garner CE; Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, United States of America., Doyle-Eisele M; Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, United States of America., Wegerski CJ; Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, United States of America., Waidyanatha S; Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States of America. Electronic address: waidyanathas@niehs.nih.gov. |
المصدر: | Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2019 Sep 01; Vol. 378, pp. 114592. Date of Electronic Publication: 2019 May 14. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
اللغة: | English |
بيانات الدورية: | Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0333 (Electronic) Linking ISSN: 0041008X NLM ISO Abbreviation: Toxicol Appl Pharmacol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: New York, NY : Academic Press Original Publication: New York. |
مواضيع طبية MeSH: | Choline/*administration & dosage , Choline/*metabolism , Deanol/*administration & dosage , Deanol/*metabolism, Administration, Intravenous ; Administration, Oral ; Animals ; Dimethylnitrosamine/metabolism ; Female ; Male ; Mice ; Rats ; Rats, Wistar ; Tissue Distribution/physiology |
مستخلص: | Dimethylaminoethanol (DMAE) and its salts have been used to treat numerous disorders in humans and hence safety of its use is a concern. DMAE is a close structural analog of choline, an essential nutrient. Exposure to DMAE may affect choline uptake and synthesis. The current investigation characterizes: 1) the absorption, distribution, metabolism, and excretion (ADME) of DMAE in Wistar Han rats and B6C3F1 mice following a single gavage or intravenous (IV) administration of 10, 100 or 500 mg/kg [ 14 C]DMAE, and 2) the ADME of [ 14 C]choline (160 mg/kg) and the effect on its disposition following pre-treatment with DMAE (100 or 500 mg/kg). In both rats and mice, following gavage administration, DMAE was excreted in urine (16-69%) and as exhaled CO (Published by Elsevier Inc.) |
References: | Mech Ageing Dev. 1988 Feb;42(2):129-38. (PMID: 3361965) Drug Dev Ind Pharm. 2002 Aug;28(7):773-81. (PMID: 12236063) J Pharmacol Exp Ther. 1958 Dec;124(4):290-5. (PMID: 13611630) Bioorg Med Chem. 2007 Nov 15;15(22):7042-7. (PMID: 17827016) J Biol Chem. 2010 Mar 12;285(11):8031-44. (PMID: 20061389) J Neurochem. 1981 Aug;37(2):476-82. (PMID: 7264671) Am J Clin Nutr. 2014 Oct;100(4):1069-74. (PMID: 25240073) Xenobiotica. 1997 Jul;27(7):733-46. (PMID: 9253149) Clin Chem. 2008 Mar;54(3):590-3. (PMID: 18310145) Drugs. 1977 Oct;14(4):300-10. (PMID: 144049) J Lipid Res. 1985 Jan;26(1):135-40. (PMID: 3973509) FASEB J. 2002 Apr;16(6):619-21. (PMID: 11919173) J Pharmacol Exp Ther. 1990 Jan;252(1):154-8. (PMID: 2405150) J Drug Target. 2005 May;13(4):259-66. (PMID: 16051538) J Neurochem. 1986 Apr;46(4):1170-5. (PMID: 3950622) Am J Epidemiol. 2004 Jul 15;160(2):102-9. (PMID: 15234930) J Biol Chem. 1957 May;226(1):497-509. (PMID: 13428781) Drug Dev Ind Pharm. 2002 Aug;28(7):749-71. (PMID: 12236062) Toxicol Ind Health. 1997 Jul-Aug;13(4):407-84. (PMID: 9249929) J Neurochem. 1994 Apr;62(4):1449-57. (PMID: 8133274) J Pharmacol Exp Ther. 1979 Dec;211(3):472-9. (PMID: 512912) Epidemiology. 2009 Sep;20(5):714-9. (PMID: 19593156) Teratology. 2001 Aug;64(2):114-22. (PMID: 11460263) J Pharmacol Exp Ther. 1977 Mar;200(3):545-59. (PMID: 850128) Science. 1957 Sep 27;126(3274):610-1. (PMID: 13467254) J Biol Chem. 1996 Nov 1;271(44):27321-9. (PMID: 8910308) J Neurochem. 1992 Mar;58(3):870-6. (PMID: 1737995) Arzneimittelforschung. 1975 Feb;25(2):201-7. (PMID: 1173033) |
معلومات مُعتمدة: | N01ES75562 United States ES NIEHS NIH HHS |
فهرسة مساهمة: | Keywords: Choline; Dimethylaminoethanol; Disposition; Metabolism; N-N-dimethylnitrosamine; Tissue distribution |
المشرفين على المادة: | 2N6K9DRA24 (Deanol) M43H21IO8R (Dimethylnitrosamine) N91BDP6H0X (Choline) |
تواريخ الأحداث: | Date Created: 20190518 Date Completed: 20200520 Latest Revision: 20200529 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC7252906 |
DOI: | 10.1016/j.taap.2019.05.011 |
PMID: | 31100288 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1096-0333 |
---|---|
DOI: | 10.1016/j.taap.2019.05.011 |