Comparative disposition of dimethylaminoethanol and choline in rats and mice following oral or intravenous administration.

التفاصيل البيبلوغرافية
العنوان:	Comparative disposition of dimethylaminoethanol and choline in rats and mice following oral or intravenous administration.
المؤلفون:	Shipkowski KA; Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States of America., Sanders JM; Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States of America., McDonald JD; Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, United States of America., Garner CE; Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, United States of America., Doyle-Eisele M; Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, United States of America., Wegerski CJ; Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, United States of America., Waidyanatha S; Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States of America. Electronic address: waidyanathas@niehs.nih.gov.
المصدر:	Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2019 Sep 01; Vol. 378, pp. 114592. Date of Electronic Publication: 2019 May 14.
نوع المنشور:	Journal Article; Research Support, N.I.H., Extramural
اللغة:	English
بيانات الدورية:	Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0333 (Electronic) Linking ISSN: 0041008X NLM ISO Abbreviation: Toxicol Appl Pharmacol Subsets: MEDLINE
أسماء مطبوعة:	Publication: New York, NY : Academic Press Original Publication: New York.
مواضيع طبية MeSH:	Choline/administration & dosage , Choline/metabolism , Deanol/administration & dosage , Deanol/metabolism, Administration, Intravenous ; Administration, Oral ; Animals ; Dimethylnitrosamine/metabolism ; Female ; Male ; Mice ; Rats ; Rats, Wistar ; Tissue Distribution/physiology
مستخلص:	Dimethylaminoethanol (DMAE) and its salts have been used to treat numerous disorders in humans and hence safety of its use is a concern. DMAE is a close structural analog of choline, an essential nutrient. Exposure to DMAE may affect choline uptake and synthesis. The current investigation characterizes: 1) the absorption, distribution, metabolism, and excretion (ADME) of DMAE in Wistar Han rats and B6C3F1 mice following a single gavage or intravenous (IV) administration of 10, 100 or 500 mg/kg [ ¹⁴ C]DMAE, and 2) the ADME of [ ¹⁴ C]choline (160 mg/kg) and the effect on its disposition following pre-treatment with DMAE (100 or 500 mg/kg). In both rats and mice, following gavage administration, DMAE was excreted in urine (16-69%) and as exhaled CO 2 (3-22%). The tissue retention was moderate (21-44%); however, the brain concentrations were low and there was no accumulation. Serum choline levels were not elevated following administration of DMAE. The DMAE metabolites in urine were DMAE N-oxide and N,N-dimethylglycine; the carcinogen, N-N-dimethylnitrosamine, was not detected. The pattern of disposition of [ ¹⁴ C]choline following gavage administration was similar to that of [ ¹⁴ C]DMAE. Prior treatment with DMAE had minimal effects on choline disposition. The pattern of disposition of [ ¹⁴ C]DMAE and [ ¹⁴ C]choline following IV administration was similar to gavage administration. There were minimal dose-, sex- or species-related effects following gavage or IV administration of [ ¹⁴ C]DMAE or [ ¹⁴ C]choline. Data from the current study did not support previous reports that: 1) DMAE alters choline uptake and distribution, or 2) that DMAE is converted into choline in vivo. (Published by Elsevier Inc.)
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معلومات مُعتمدة:	N01ES75562 United States ES NIEHS NIH HHS
فهرسة مساهمة:	Keywords: Choline; Dimethylaminoethanol; Disposition; Metabolism; N-N-dimethylnitrosamine; Tissue distribution
المشرفين على المادة:	2N6K9DRA24 (Deanol) M43H21IO8R (Dimethylnitrosamine) N91BDP6H0X (Choline)
تواريخ الأحداث:	Date Created: 20190518 Date Completed: 20200520 Latest Revision: 20200529
رمز التحديث:	20240628
مُعرف محوري في PubMed:	PMC7252906
DOI:	10.1016/j.taap.2019.05.011
PMID:	31100288
قاعدة البيانات:	MEDLINE

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تدمد:	1096-0333
DOI:	10.1016/j.taap.2019.05.011