دورية أكاديمية
Association between aortic telomere length and cardiac post-transplant allograft function.
| العنوان: | Association between aortic telomere length and cardiac post-transplant allograft function. |
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| المؤلفون: | Dlouha D; Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Videnska 1958/9, Prague 14021, Czech Republic. Electronic address: dadl@ikem.cz., Vymetalova J; Cardio Centre, Institute for Clinical and Experimental Medicine, Videnska 1958/9, Prague 14021, Czech Republic., Hubacek JA; Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Videnska 1958/9, Prague 14021, Czech Republic., Lanska V; Statistical Unit, Institute for Clinical and Experimental Medicine, Videnska 1958/9, Prague 14021, Czech Republic., Malek I; Cardio Centre, Institute for Clinical and Experimental Medicine, Videnska 1958/9, Prague 14021, Czech Republic. |
| المصدر: | International journal of cardiology [Int J Cardiol] 2019 Sep 01; Vol. 290, pp. 129-133. Date of Electronic Publication: 2019 May 07. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8200291 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1874-1754 (Electronic) Linking ISSN: 01675273 NLM ISO Abbreviation: Int J Cardiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: Amsterdam : Elsevier/North-Holland Biomedical Press, c1981- |
| مواضيع طبية MeSH: | Aorta/*physiology , Graft Rejection/*diagnosis , Graft Rejection/*genetics , Heart Transplantation/*trends , Telomere Shortening/*physiology , Transplantation, Homologous/*trends, Adult ; Female ; Graft Rejection/physiopathology ; Humans ; Male ; Middle Aged ; Telomere/physiology ; Tissue Donors |
| مستخلص: | Background: In patients having undergone orthotopic heart transplantation, a number of complications exist that are known to be connected to both telomerase activity and telomere length. The aim of this study was to determine how telomere length in aortic DNA correlates with the subsequent post-transplantation development of the patients. Materials and Methods: Between 2005 and 2015, we collected aortic samples from 376 heart recipients (age 50.8 ± 11.8 years) and 383 donors (age 38.6 ± 12.2 years). Relative telomere length in aortic tissue DNA was determined using quantitative PCR. Results: Shorter telomere length was detected in heart allograft recipients compared to donors (P < 0.0001). Patients suffering acute cellular rejection had significantly shorter telomere length (P < 0.01) than patients without rejection. Shorter telomere length was observed in patients with implanted mechanical circulatory support before heart transplantation (P < 0.03), as well as in subjects with cardiac allograft vasculopathy (P < 0.05). Overall survival time after heart transplantation was associated with shorter donor telomeres (P < 0.004). Conclusions: Telomere length differed between donors and recipients independent of the sex and age of the patients. Our findings suggest a potential new linkage between the aortic telomere length of recipients and post-heart transplant complications. Further studies focusing on epigenetic modifications and gene regulation involved in telomere maintenance in transplanted patients should verify our results. (Copyright © 2019 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Aortic tissue; Cellular rejection; DNA; Heart transplantation; Telomere length |
| تواريخ الأحداث: | Date Created: 20190519 Date Completed: 20200507 Latest Revision: 20200507 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.ijcard.2019.05.006 |
| PMID: | 31101542 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1874-1754 |
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| DOI: | 10.1016/j.ijcard.2019.05.006 |