دورية أكاديمية
أعرض في EDS

Pulmonary Endothelial Mechanical Sensing and Signaling, a Story of Focal Adhesions and Integrins in Ventilator Induced Lung Injury.

التفاصيل البيبلوغرافية
العنوان: Pulmonary Endothelial Mechanical Sensing and Signaling, a Story of Focal Adhesions and Integrins in Ventilator Induced Lung Injury.
المؤلفون: Kelly GT; Department of Internal Medicine, College of Medicine Phoenix, The University of Arizona, Phoenix, AZ, United States., Faraj R; Department of Internal Medicine, College of Medicine Phoenix, The University of Arizona, Phoenix, AZ, United States., Zhang Y; Department of Internal Medicine, College of Medicine Phoenix, The University of Arizona, Phoenix, AZ, United States., Maltepe E; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, United States., Fineman JR; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, United States., Black SM; Department of Medicine, College of Medicine, The University of Arizona, Tucson, AZ, United States., Wang T; Department of Internal Medicine, College of Medicine Phoenix, The University of Arizona, Phoenix, AZ, United States.
المصدر: Frontiers in physiology [Front Physiol] 2019 Apr 26; Vol. 10, pp. 511. Date of Electronic Publication: 2019 Apr 26 (Print Publication: 2019).
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101549006 Publication Model: eCollection Cited Medium: Print ISSN: 1664-042X (Print) Linking ISSN: 1664042X NLM ISO Abbreviation: Front Physiol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Research Foundation
مستخلص: Patients with critical illness such as acute lung injury often undergo mechanical ventilation in the intensive care unit. Though lifesaving in many instances, mechanical ventilation often results in ventilator induced lung injury (VILI), characterized by overdistension of lung tissue leading to release of edemagenic agents, which further damage the lung and contribute to the mortality and progression of pulmonary inflammation. The endothelium is particularly sensitive, as VILI associated mechanical stress results in endothelial cytoskeletal rearrangement, stress fiber formation, and integrity loss. At the heart of these changes are integrin tethered focal adhesions (FAs) which participate in mechanosensing, structure, and signaling. Here, we present the known roles of FA proteins including c-Src, talin, FAK, paxillin, vinculin, and integrins in the sensing and response to cyclic stretch and VILI associated stress. Attention is given to how stretch is propagated from the extracellular matrix through integrins to talin and other FA proteins, as well as signaling cascades that include FA proteins, leading to stress fiber formation and other cellular responses. This unifying picture of FAs aids our understanding in an effort to prevent and treat VILI.
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معلومات مُعتمدة: P01 HL134610 United States HL NHLBI NIH HHS; R01 HL142212 United States HL NHLBI NIH HHS; R01 HL137282 United States HL NHLBI NIH HHS; R01 HL060190 United States HL NHLBI NIH HHS; T32 HD049303 United States HD NICHD NIH HHS
فهرسة مساهمة: Keywords: ARDS; VILI; cyclic stretch; focal adhesion; integrin β4; mechanical stress
تواريخ الأحداث: Date Created: 20190521 Latest Revision: 20201001
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC6498899
DOI: 10.3389/fphys.2019.00511
PMID: 31105595
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-042X
DOI:10.3389/fphys.2019.00511