دورية أكاديمية
أعرض في EDS

Krt5 + /Krt15 + foregut basal progenitors give rise to cyclooxygenase-2-dependent tumours in response to gastric acid stress.

التفاصيل البيبلوغرافية
العنوان: Krt5 + /Krt15 + foregut basal progenitors give rise to cyclooxygenase-2-dependent tumours in response to gastric acid stress.
المؤلفون: Moon H; Department of Biomedical Sciences, Cornell University, Ithaca, NY, 14853, USA., Zhu J; Department of Biomedical Sciences, Cornell University, Ithaca, NY, 14853, USA., Donahue LR; Department of Biomedical Sciences, Cornell University, Ithaca, NY, 14853, USA., Choi E; Department of Pathology, Microbiology and Immunology, University of California Davis, Davis, CA, 95616, USA., White AC; Department of Biomedical Sciences, Cornell University, Ithaca, NY, 14853, USA. acw93@cornell.edu.
المصدر: Nature communications [Nat Commun] 2019 May 20; Vol. 10 (1), pp. 2225. Date of Electronic Publication: 2019 May 20.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Carcinogenesis/*pathology , Cyclooxygenase 2/*metabolism , Gastric Acid/*metabolism , Gastrointestinal Neoplasms/*pathology , Stem Cells/*pathology, Animals ; Cell Differentiation/drug effects ; Digestive System/pathology ; Epithelial Cells/pathology ; Epithelium/pathology ; Gastrointestinal Neoplasms/etiology ; Keratin-15/genetics ; Keratin-15/metabolism ; Keratin-5/genetics ; Keratin-5/metabolism ; Mice ; Mice, Transgenic ; Neoplasms, Experimental/etiology ; Neoplasms, Experimental/pathology ; Proton Pump Inhibitors/pharmacology ; Stress, Physiological/drug effects ; Tumor Microenvironment
مستخلص: The effective prevention of tumor initiation, especially for potentially inoperable tumors, will be beneficial to obtain an overall higher quality of our health and life. Hence, thorough understanding of the pathophysiological mechanisms of early tumor formation arising from identifiable cellular origins is required to develop efficient preventative and early treatment options for each tumor type. Here, using genetically engineered mouse models, we provide preclinical experimental evidence for a long-standing open question regarding the pathophysiological potential of a microenvironmental and physiological stressor in tumor development, gastric acid-mediated regional microscopic injury in foregut squamous epithelia. This study demonstrates the association of gastric acid stress with Cyclooxygenase-2-dependent tumor formation originating from tumor-competent Krt5 + /Krt15 + foregut basal progenitor cells. Our findings suggest that clinical management of microenvironmental stressor-mediated microscopic injury may be important in delaying tumor initiation from foregut basal progenitor cells expressing pre-existing tumorigenic mutation(s) and genetic alteration(s).
التعليقات: Comment in: Nat Commun. 2019 Aug 23;10(1):3829. (PMID: 31444324)
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المشرفين على المادة: 0 (Keratin-15)
0 (Keratin-5)
0 (Krt15 protein, mouse)
0 (Proton Pump Inhibitors)
EC 1.14.99.- (Ptgs2 protein, mouse)
EC 1.14.99.1 (Cyclooxygenase 2)
تواريخ الأحداث: Date Created: 20190522 Date Completed: 20190606 Latest Revision: 20210109
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6527614
DOI: 10.1038/s41467-019-10194-0
PMID: 31110179
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-019-10194-0