دورية أكاديمية
An amplitude code transmits information at a visual synapse.
| العنوان: | An amplitude code transmits information at a visual synapse. |
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| المؤلفون: | James B; School of Life Sciences, University of Sussex, Brighton, UK., Darnet L; School of Life Sciences, University of Sussex, Brighton, UK., Moya-Díaz J; School of Life Sciences, University of Sussex, Brighton, UK., Seibel SH; School of Life Sciences, University of Sussex, Brighton, UK., Lagnado L; School of Life Sciences, University of Sussex, Brighton, UK. l.lagnado@sussex.ac.uk. |
| المصدر: | Nature neuroscience [Nat Neurosci] 2019 Jul; Vol. 22 (7), pp. 1140-1147. Date of Electronic Publication: 2019 May 20. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9809671 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1726 (Electronic) Linking ISSN: 10976256 NLM ISO Abbreviation: Nat Neurosci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2002->: New York, NY : Nature Publishing Group Original Publication: New York, NY : Nature America Inc., c1998- |
| مواضيع طبية MeSH: | Retinal Bipolar Cells/*physiology , Synaptic Transmission/*physiology , Synaptic Vesicles/*physiology , Visual Pathways/*physiology, Action Potentials ; Animals ; Genes, Reporter ; Glutamic Acid/physiology ; Membrane Fusion ; Patch-Clamp Techniques ; Signal Detection, Psychological ; Zebrafish/physiology |
| مستخلص: | Most neurons transmit information digitally using spikes that trigger the release of synaptic vesicles with low probability. The first stages of vision and hearing are distinct in that they operate with analog signals, but it is unclear how these are recoded for synaptic transmission. By imaging the release of glutamate in live zebrafish, we demonstrate that ribbon synapses of retinal bipolar cells encode contrast through changes in both the frequency and amplitude of release events. Higher contrasts caused multiple vesicles to be released within an event, and such coding by amplitude often continued after the rate code had reached a maximum frequency. Glutamate packets equivalent to five vesicles transmitted four times as many bits of information per vesicle compared with those released individually. By discretizing analog signals into sequences of numbers up to about 11, ribbon synapses can increase the dynamic range, temporal precision and efficiency with which visual information is transmitted. |
| المشرفين على المادة: | 3KX376GY7L (Glutamic Acid) |
| تواريخ الأحداث: | Date Created: 20190522 Date Completed: 20190718 Latest Revision: 20200519 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1038/s41593-019-0403-6 |
| PMID: | 31110322 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1546-1726 |
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| DOI: | 10.1038/s41593-019-0403-6 |