دورية أكاديمية
أعرض في EDS

KLF5 functions in proliferation, differentiation, and apoptosis of chicken satellite cells.

التفاصيل البيبلوغرافية
العنوان: KLF5 functions in proliferation, differentiation, and apoptosis of chicken satellite cells.
المؤلفون: Zhang XX; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu Campus, Chengdu, 611130 China., Lian T; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu Campus, Chengdu, 611130 China., Ran JS; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu Campus, Chengdu, 611130 China., Li ZQ; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu Campus, Chengdu, 611130 China., Han SS; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu Campus, Chengdu, 611130 China., Liu YP; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu Campus, Chengdu, 611130 China.
المصدر: 3 Biotech [3 Biotech] 2019 Jun; Vol. 9 (6), pp. 222. Date of Electronic Publication: 2019 May 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Germany NLM ID: 101565857 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2190-572X (Print) Linking ISSN: 21905738 NLM ISO Abbreviation: 3 Biotech Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Berlin : Springer
مستخلص: KLF5 is an important regulator of cell proliferation, differentiation, and apoptosis in mammals. Little is known about the function of KLF5 in the regulation of chicken. Hence, qPCR was used to detect the expression of KLF5 in different tissues of chicken. And chicken skeletal muscle satellite cells (SMSCs) were transfected KLF5 -specific small interfering RNA (siRNA) to assay SMSCs' proliferation, differentiation, and apoptosis. The results showed that KLF5 expressed higher in skeletal muscle than in the other tissues of chicken. Knockdown of KLF5 significantly inhibited the differentiation and increased apoptosis of chicken SMSCs, but it had no significant effect on proliferation of SMSCs. These results indicate that KLF5 plays an essential role during myogenesis, which will affect muscle repair and muscle regeneration, and may ameliorate muscle aging or sarcopenia.
Competing Interests: Conflict of interestOn behalf of all authors, the corresponding author states that there is no conflict of interest.
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فهرسة مساهمة: Keywords: Apoptosis; Chicken satellite cells; Differentiation; KLF5; Proliferation
تواريخ الأحداث: Date Created: 20190523 Latest Revision: 20201001
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6527724
DOI: 10.1007/s13205-019-1752-2
PMID: 31114746
قاعدة البيانات: MEDLINE
الوصف
تدمد:2190-572X
DOI:10.1007/s13205-019-1752-2