دورية أكاديمية
أعرض في EDS

Detection of human immunodeficiency virus Type 1 phylogenetic clusters with multidrug resistance mutations among 2011 to 2017 blood donors from the highly endemic Northern Brazilian Amazon.

التفاصيل البيبلوغرافية
العنوان: Detection of human immunodeficiency virus Type 1 phylogenetic clusters with multidrug resistance mutations among 2011 to 2017 blood donors from the highly endemic Northern Brazilian Amazon.
المؤلفون: Esashika Crispim MA; Fundação de Hematologia e Hemoterapia do Amazonas, HEMOAM, Manaus, Brazil., da Guarda Reis MN; Laboratório de Imunologia da AIDS e da Hanseniase, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, Goiás, Brazil., Fraiji N; Fundação de Hematologia e Hemoterapia do Amazonas, HEMOAM, Manaus, Brazil., Bello G; Laboratório de AIDS e Imunologia Molecular, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil., Stefani MMA; Laboratório de Imunologia da AIDS e da Hanseniase, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, Goiás, Brazil.
المصدر: Transfusion [Transfusion] 2019 Aug; Vol. 59 (8), pp. 2593-2601. Date of Electronic Publication: 2019 May 23.
نوع المنشور: Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: American Association Of Blood Banks Country of Publication: United States NLM ID: 0417360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-2995 (Electronic) Linking ISSN: 00411132 NLM ISO Abbreviation: Transfusion Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Arlington, Va. : American Association Of Blood Banks
مواضيع طبية MeSH: Blood Donors* , Mutation* , Phylogeny*, Drug Resistance, Multiple, Viral/*genetics , HIV Infections/*genetics , HIV Protease/*genetics , HIV Reverse Transcriptase/*genetics , HIV-1/*genetics, Adult ; Brazil/epidemiology ; Cross-Sectional Studies ; Female ; HIV Infections/enzymology ; HIV Infections/epidemiology ; HIV-1/enzymology ; Humans ; Male
مستخلص: Background: This study describes transmitted drug resistance (TDR) in blood donors diagnosed with human immunodeficiency virus Type 1 (HIV-1) infection from 2011 to 2017 in three reference public blood centers from the Northern Brazilian Amazon.
Study Design and Methods: This was a cross-sectional study on HIV-positive blood donors from HEMOAM, Manaus, Amazonas, AM (n = 198); HEMERON, Porto Velho, Rondônia, RO (n = 20); and HEMORAIMA, Boa Vista, Roraima, RR (n = 9). HIV-1 pol sequences (protease, reverse transcriptase) were analyzed for drug resistance mutations (DRMs) using the Calibrated Population Resistance tool (Stanford). TDR/DRM clusters were investigated by phylogenetic analysis after removing positions associated with drug resistance of Subtype B sequences from untreated and treated subjects from Northern Brazil.
Results: Transmitted drug resistance/DRM in blood donors was 11% (25 of 227), all of them from HEMOAM. Most blood donors with TDR/DRM had multiple and similar DRMs. Nonnucleoside reverse transcriptase inhibitor (NNRTI) mutations predominated (10.1%), followed by nucleoside reverse transcriptase inhibitor (NRTI) mutations (5.3%) and protease inhibitor mutations (0.4%). Dual-class NNRTI/NRTI mutations represented 4.8%. Three highly supported Subtype B monophyletic clades mostly composed by individuals from Amazonas with TDR/DRM mutations were identified. The largest transmission cluster contained 10 sequences, eight from HEMOAM and two sequences described previously (one from a treated subject from Amazonas and the other one from Roraima). This cluster was characterized by NRTI (D67N, T69D, T215S/F/L, K219Q) and NNRTI (K101H, K103 N, G190A) mutations. The other two transmission clades comprised only three and two sequences from HEMOAM sharing the E138A NNRTI mutation.
Conclusions: The identification of transmission clusters of multidrug-resistant viruses in blood donors from Amazonas highlight the need of continued monitoring of TDR/DRM and the importance of pretreatment genotyping in the highly endemic Amazonas state.
(© 2019 AABB.)
References: Brazilian Ministry of Health. Epidemiological bulletin HIV/AIDS 2018 [Internet]. Rio de Janeiro: Brazilian Ministry of Health; 2018 [cited 2019 March 13]. Available from: http://www.aids.gov.br/pt-br/pub/2018/boletim-epidemiologico-hivaids-2018.
Gagliani LH, Alkmim Maia WT, Sá-Filho D, et al. The association between primary antiretroviral resistance and HAART virologic failure in a developing set. AIDS Res Hum Retroviruses 2011;27:251-6.
Barreto CC, Nishyia A, Araújo LV, et al. Trends in antiretroviral drug resistance and clade distributions among HIV-1 infected blood donors in Sao Paulo, Brazil. J Acquir Immune Defic Syndr 2006;41:338-41.
Gonsalez CR, Alcalde R, Nishiya A, et al. Drug resistance among chronic HIV-1-infected patients naive for use of anti-retroviral therapy in Sao Paulo city. Virus Res 2007;129:87-90.
Cardoso LP, Queiroz BB, Stefani MM. HIV-1 pol phylogenetic diversity and antiretroviral resistance mutations in treatment naive patients from Central West Brazil. J Clin Virol 2009;46:134-9.
Inocencio LA, Pereira AA, Sucupira MC, et al. Brazilian betwork for HIV drug resistance surveillance: a survey of individuals recently diagnosed with HIV. J Int AIDS Soc 2009;12:20.
Sprinz E, Netto EM, Patelli M, et al. Primary antiretroviral drug resistance among HIV type 1-infected individuals in Brazil. AIDS Res Hum Retroviruses 2009;25:861-7.
Carvalho BC, Cardoso LP, Damasceno S, et al. Moderate prevalence of transmitted drug resistance and interiorization of HIV type 1 subtype C in the inland North State of Tocantins, Brazil. AIDS Res Hum Retroviruses 2011;27:1081-7.
Ferreira AS, Cardoso LP, Stefani MMA. Moderate prevalence of transmitted drug resistance and high HIV-1 genetic diversity in patients from Mato Grosso State, Central Western Brazil. J Med Virol 2011;83:1301-7.
Alencar CS, Sabino EC, Carvalho SM, et al. HIV genotypes and primary drug resistance among HIV-seropositive blood donors in Brazil: role of infected blood donors as sentinel populations for molecular surveillance of HIV. J Acquir Immune Defic Syndr 2013;63:387-92.
Moura ME, da Guarda Reis MN, Lima YA, et al. HIV-1 transmitted drug resistance and genetic diversity among patients from Piauí State, Northeast Brazil. J Med Virol 2015;87:798-806.
Arruda MB, Boullosa LT, Cardoso CC, et al. Brazilian network for HIV Drug Resistance Surveillance (HIV-BresNet): a survey of treatment-naive individuals. J Int AIDS Soc 2018;21:e25032.
Andrade SD, Sabidó M, Monteiro WM, et al. Drug resistance in antiretroviral-naive children newly diagnosed with HIV-1 in Manaus, Amazonas. J Antimicrob Chemother 2017;72:1774-8.
Machado LF, Costa IB, Folha MN, et al. Lower genetic variability of HIV-1 and antiretroviral drug resistance in pregnant women from the state of Pará, Brazil. BMC Infect Dis 2017;17:270.
Corado AL, Bello G, Leão RA, et al. HIV-1 genetic diversity and antiretroviral drug resistance among individuals from Roraima state, northern Brazil. PLoS One 2017;12:e0173894.
Lopes CA, Soares MA, Falci DR, et al. The evolving genotypic profile of HIV-1 mutations related to antiretroviral treatment in the North region of Brazil. Biomed Res Int 2015;2015:738528.
Dos Anjos Silva L, Divino F, da Silva Rego MO, et al. HIV-1 genetic diversity and transmitted drug resistance in antiretroviral treatment-naive individuals from Amapa State, Northern Brazil. AIDS Res Hum Retroviruses 2016;32:373-6.
Viga-Yurtsever S, Fraiji N, Lira E, et al. High rate of HIV infection in voluntary, first time, young male donors at HEMOAM, a reference blood bank in the Brazilian Amazon: 1992-2012 historical series. ISBT Sci Ser 2015;10:18-26.
Souza JC, Crispim ME, Abrahim C, et al. High rate of seromarkers for HIV, HBV and syphilis among blood donors using confidential unit exclusion, before and after HIV-NAT implementation at a major public blood bank in the Brazilian Amazon. Transfusion 2019;59:629-38.
Frenkel LM, Wagner LE, Atwood SM, et al. Specific, sensitive, and rapid assay for human immunodeficiency virus type 1 pol mutations associated with resistance to zidovudine and didanosine. J Clin Microbiol 1995;33:342-7.
Kozal MJ, Shah N, Shen N, et al. Extensive polymorphisms observed in HIV-1 clade B protease gene using high-density oligonucleotide arrays. Nat Med 1996;2:753-9.
Lehvaslaiho H, Hide W, and Oliveira T. South African National Bioinformatics Institute [Internet]. Bellville (Cape Town): University of Western Cape; [cited 2018 December 20]. Available from: https://www.sanbi.ac.za/.
Hall TA. BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95=98=MT. In Nucleic Acids Symposium Series; 1999. p. 95-98.
Gifford RJ, Liu TF, Rhee SY, et al. The calibrated population resistance tool: standardized genotypic estimation of transmitted HIV-1 drug resistance. Bioinformatics 2009;25:1197-8.
Shafer RW, Rhee SY, Pillay D, et al. HIV-1 protease and reverse transcriptase mutations for drug resistance surveillance. AIDS 2007;21:215-23.
Bennett DE, Camacho RJ, Otelea D, et al. Drug resistance mutations for surveillance of transmitted HIV-1 drug-resistance: 2009 update. PLoS One 2009;4:e4724.
Oliveira T, Deforche K, Cassol S, et al. An automated genotyping system for analysis of HIV-1 and other microbial sequences. Bioinformatics 2005;21:3797-800.
Zhang M, Schultz AK, Calef C, et al. jpHMM at GOBICS: a web server to detect genomic recombinations in HIV-1. Nucleic Acids Res 2006;34:463-5.
da Costa CM, Costa de Oliveira CM, Chehuan de Melo YF, et al. High HIV-1 genetic diversity in patients from Northern Brazil. AIDS Res Hum Retroviruses 2016;32:918-22.
Bermudez-Aza EH, Kerr LR, Kendall C, et al. Antiretroviral drug resistance in a respondent-driven sample of HIV-infected men who have sex with men in Brazil. J Acquir Immune Defic Syndr 2011;57:S186-92.
Guindon S, Dufayard JF, Lefort V, et al. New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. Syst Biol 2010;59:307-21.
Lefort V, Longueville JE, Gascuel O. SMS: smart model selection in PhyML. Mol Biol Evol 2017;34:2422-4.
Anisimova M, Gascuel O. Approximate likelihood-ratio test for branches: a fast, accurate, and powerful alternative. Syst Biol 2006;55:539-52.
Wertheim JO, Leigh Brown AJ, Hepler NL, et al. The global transmission network of HIV-1. J Infect Dis 2014;209:304-13.
Volz EM, Koopman JS, Ward MJ, et al. Simple epidemiological dynamics explain phylogenetic clustering of HIV from patients with recent infection. PLoS Comput Biol 2012;8:e1002552.
Leigh Brown AJ, Lycett SJ, Weinert L, et al. Transmission network parameters estimated from HIV sequences for a nationwide epidemic. J Infect Dis 2011;204:1463-9.
Wawer MJ, Gray RH, Sewankambo NK, et al. Rates of HIV-1 transmission per coital act, by stage of HIV-1 infection, in Rakai, Uganda. J Infect Dis 2005;191:1403-9.
Pessôa R, Sanabani SS. High prevalence of HIV-1 transmitted drug-resistance mutations from proviral DNA massively parallel sequencing data of therapy-naive chronically infected Brazilian blood donors. PLoS One 2017;12:e0185559.
Li JZ, Paredes R, Ribaudo HJ, et al. Low-frequency HIV-1 drug resistance mutations and risk of NNRTI-based antiretroviral treatment failure: a systematic review and pooled analysis. JAMA 2011;305:1327-35.
Gianella S, Richman DD. Minority variants of drug-resistant HIV. J Infect Dis 2010;202:657-66.
المشرفين على المادة: EC 2.7.7.- (reverse transcriptase, Human immunodeficiency virus 1)
EC 2.7.7.49 (HIV Reverse Transcriptase)
EC 3.4.23.- (HIV Protease)
تواريخ الأحداث: Date Created: 20190524 Date Completed: 20200601 Latest Revision: 20210316
رمز التحديث: 20231215
DOI: 10.1111/trf.15347
PMID: 31119759
قاعدة البيانات: MEDLINE
الوصف
تدمد:1537-2995
DOI:10.1111/trf.15347