دورية أكاديمية
Nectandra as a renewable source for (+)-α-bisabolol, an antibiofilm and anti-Trichomonas vaginalis compound.
| العنوان: | Nectandra as a renewable source for (+)-α-bisabolol, an antibiofilm and anti-Trichomonas vaginalis compound. |
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| المؤلفون: | Farias KS; Laboratório de Produtos Naturais e Espectrometria de Massas (LaPNEM), Faculdade de Ciências Farmacêuticas, Alimentos e Nutrição (FACFAN), Universidade Federal de Mato Grosso do Sul (UFMS), 79070-900, Campo Grande, MS, Brazil., Kato NN; Laboratório de Produtos Naturais e Espectrometria de Massas (LaPNEM), Faculdade de Ciências Farmacêuticas, Alimentos e Nutrição (FACFAN), Universidade Federal de Mato Grosso do Sul (UFMS), 79070-900, Campo Grande, MS, Brazil., Boaretto AG; Laboratório de Produtos Naturais e Espectrometria de Massas (LaPNEM), Faculdade de Ciências Farmacêuticas, Alimentos e Nutrição (FACFAN), Universidade Federal de Mato Grosso do Sul (UFMS), 79070-900, Campo Grande, MS, Brazil., Weber JI; Laboratório de Pesquisa em Parasitologia, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), 90040-060, Porto Alegre, RS, Brazil., Brust FR; Laboratório de Biofilmes e Diversidade Microbiana (LaBDiM), Faculdade de Farmácia e Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul (UFRGS), 90040-060, Porto Alegre, RS, Brazil., Alves FM; Laboratório de Botânica, Instituto de Biociências (INBIO), Universidade Federal de Mato Grosso do Sul (UFMS), 79070-900, Campo Grande, MS, Brazil., Tasca T; Laboratório de Pesquisa em Parasitologia, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), 90040-060, Porto Alegre, RS, Brazil., Macedo AJ; Laboratório de Biofilmes e Diversidade Microbiana (LaBDiM), Faculdade de Farmácia e Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul (UFRGS), 90040-060, Porto Alegre, RS, Brazil., Silva DB; Laboratório de Produtos Naturais e Espectrometria de Massas (LaPNEM), Faculdade de Ciências Farmacêuticas, Alimentos e Nutrição (FACFAN), Universidade Federal de Mato Grosso do Sul (UFMS), 79070-900, Campo Grande, MS, Brazil., Carollo CA; Laboratório de Produtos Naturais e Espectrometria de Massas (LaPNEM), Faculdade de Ciências Farmacêuticas, Alimentos e Nutrição (FACFAN), Universidade Federal de Mato Grosso do Sul (UFMS), 79070-900, Campo Grande, MS, Brazil. Electronic address: carlos.carollo@ufms.br. |
| المصدر: | Fitoterapia [Fitoterapia] 2019 Jul; Vol. 136, pp. 104179. Date of Electronic Publication: 2019 May 21. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 16930290R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6971 (Electronic) Linking ISSN: 0367326X NLM ISO Abbreviation: Fitoterapia |
| أسماء مطبوعة: | Publication: 1999- : [Amsterdam] : Elsevier Original Publication: Milano : Inverni & Della Beffa S.p.A. |
| مواضيع طبية MeSH: | Anti-Bacterial Agents/*pharmacology , Biofilms/*drug effects , Lauraceae/*chemistry , Oils, Volatile/*pharmacology , Sesquiterpenes/*pharmacology , Trichomonas vaginalis/*drug effects, Animals ; Antiprotozoal Agents/pharmacology ; Brazil ; Chlorocebus aethiops ; Erythrocytes/drug effects ; Humans ; Monocyclic Sesquiterpenes ; Phytochemicals/pharmacology ; Plant Bark/chemistry ; Plant Leaves/chemistry ; Vero Cells |
| مستخلص: | Essential oils, mixtures of volatile compounds, are targets of research for new antimicrobial drugs. In order to verify the potential from species of the Nectandra genus, the present study evaluated the essential oils from Nectandra amazonum, Nectandra cuspidata, Nectandra gardineri, Nectandra hihua and Nectandra megapotamica to prospect samples with high concentration of a component and its antibacterial, antibiofilm and anti-Trichomonas vaginalis activities. The essential oils from the leaves and barks were extracted by steam distillation and analyzed by gas chromatography coupled to mass spectrometry (GC-MS). The concentrations of 10 and 100 μg/mL of the essential oil were evaluated and the inhibition of bacterial growth and biofilm formation were measured, while for the evaluation of anti-T. vaginalis trophozoite viability, the concentrations from 7.8 to 1000 μg/mL were tested. Seventy-three compounds were identified from essential oils, highlighted bicyclogermacrene (up to 49.9%), elemicin (up to 42.4%), intermedeol (up to 58.2%), (E)-asarone (up to 45.9%) and (+)-α-bisabolol (up to 93.7%). The essential oil from N. megapotamica leaves presented 93.7% of (+)-α-bisabolol and demonstrated the high capacity of inhibition of the biofilm formation, in particular, against Staphylococcus aureus methicillin resistant (MRSA) and Pseudomonas aeruginosa. This sample also had significant activity against T. vaginalis (IC (Copyright © 2019 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Multidrug resistant strain; Nectandra megapotamica; Pseudomonas aeruginosa; Staphylococcus aureus; Trichomonas vaginalis |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Antiprotozoal Agents) 0 (Monocyclic Sesquiterpenes) 0 (Oils, Volatile) 0 (Phytochemicals) 0 (Sesquiterpenes) 24WE03BX2T (bisabolol) |
| تواريخ الأحداث: | Date Created: 20190524 Date Completed: 20190821 Latest Revision: 20191210 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.fitote.2019.104179 |
| PMID: | 31121252 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-6971 |
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| DOI: | 10.1016/j.fitote.2019.104179 |