دورية أكاديمية
أعرض في EDS

Lower Vitamin D Levels, but Not VDR Polymorphisms, Influence Type 2 Diabetes Mellitus in Brazilian Population Independently of Obesity.

التفاصيل البيبلوغرافية
العنوان: Lower Vitamin D Levels, but Not VDR Polymorphisms, Influence Type 2 Diabetes Mellitus in Brazilian Population Independently of Obesity.
المؤلفون: Rodrigues KF; Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270-901, Brazil. katyfontanar@gmail.com., Pietrani NT; Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270-901, Brazil. ntpietrani@hotmail.com., Bosco AA; Instituto de Ensino e Pesquisa, Santa Casa de Belo Horizonte, Belo Horizonte, MG 30150-240, Brazil. a.bosco@terra.com.br., de Sousa MCR; Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270-901, Brazil. maira.crsousa@gmail.com., Silva IFO; Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270-901, Brazil. iedafos@farmacia.ufmg.br., Silveira JN; Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270-901, Brazil. nicacio@farmacia.ufmg.br., Gomes KB; Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270-901, Brazil. karinabgb@gmail.com.; Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270-901, Brazil. karinabgb@gmail.com.
المصدر: Medicina (Kaunas, Lithuania) [Medicina (Kaunas)] 2019 May 22; Vol. 55 (5). Date of Electronic Publication: 2019 May 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 9425208 Publication Model: Electronic Cited Medium: Internet ISSN: 1648-9144 (Electronic) Linking ISSN: 1010660X NLM ISO Abbreviation: Medicina (Kaunas) Subsets: MEDLINE
أسماء مطبوعة: Publication: 2018- : Basel, Switzerland : MDPI
Original Publication: Kaunas : Lietuvos gydytojų sąjunga
مواضيع طبية MeSH: Diabetes Mellitus, Type 2/*blood , Polymorphism, Genetic/*physiology , Receptors, Calcitriol/*genetics , Vitamin D Deficiency/*complications , Vitamin D Deficiency/*genetics, Adult ; Aged ; Blood Glucose/analysis ; Brazil ; Case-Control Studies ; Diabetes Mellitus, Type 2/metabolism ; Fasting/blood ; Female ; Humans ; Insulin Resistance/physiology ; Male ; Middle Aged ; Receptors, Calcitriol/analysis ; Receptors, Calcitriol/blood ; Statistics, Nonparametric ; Vitamin D/analysis ; Vitamin D/blood ; Vitamin D Deficiency/blood
مستخلص: Background and Objectives : Vitamin D levels have been associated with a diversity of diseases, including obesity. Vitamin D presents a pleiotropic action, and can regulate insulin secretion and inflammatory responses. Vitamin D receptor ( VDR ) gene polymorphisms are involved in the gene expression regulation and have been associated with type 2 diabetes mellitus (T2DM). This study aimed to evaluate the association between the polymorphisms ApaI (rs7975232), BsmI (rs1544410), FokI (rs10735810), and TaqI (rs731236) in the VDR gene in people diagnosed with T2DM, and plasma 25-hydroxivitamin D levels [25(OH)D]. Materials and Methods : A total of 101 T2DM patients and 62 gender, age, and body mass index (BMI) matched non-diabetic controls were included in this study. Molecular analyzes were performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The plasma 25(OH)D levels were measured by high performance liquid chromatography. Results : The plasma 25(OH)D levels were lower in T2DM patients (17.2 (16.6) ng/mL) when compared with the control subjects (30.8 (16.2) ng/mL, p < 0.0001), independently of obesity status. We found no difference between genotypic and allelic frequencies of the VDR polymorphisms when comparing the T2DM group and control group ( p > 0.05 for all), and did not show any association with plasma 25(OH)D levels. Conclusions : These results suggest that T2DM is associated with lower plasma 25(OH)D levels, which are not related to BMI and VDR gene polymorphisms.
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معلومات مُعتمدة: - Conselho Nacional de Desenvolvimento Científico e Tecnológico; - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
فهرسة مساهمة: Keywords: obesity; polymorphisms; type 2 diabetes mellitus; vitamin D; vitamin D receptor
المشرفين على المادة: 0 (Blood Glucose)
0 (Receptors, Calcitriol)
0 (VDR protein, human)
1406-16-2 (Vitamin D)
تواريخ الأحداث: Date Created: 20190525 Date Completed: 20191212 Latest Revision: 20200225
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC6572088
DOI: 10.3390/medicina55050188
PMID: 31121922
قاعدة البيانات: MEDLINE
الوصف
تدمد:1648-9144
DOI:10.3390/medicina55050188