دورية أكاديمية
The use of iPSC technology for modeling Autism Spectrum Disorders.
| العنوان: | The use of iPSC technology for modeling Autism Spectrum Disorders. |
|---|---|
| المؤلفون: | Russo FB; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, SP, Brazil., Brito A; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, SP, Brazil., de Freitas AM; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, SP, Brazil., Castanha A; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, SP, Brazil., de Freitas BC; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, SP, Brazil., Beltrão-Braga PCB; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, SP, Brazil; Department of Obstetrics, School of Arts Sciences and Humanities, São Paulo, SP 03828-000, Brazil. Electronic address: patriciacbbbraga@usp.br. |
| المصدر: | Neurobiology of disease [Neurobiol Dis] 2019 Oct; Vol. 130, pp. 104483. Date of Electronic Publication: 2019 May 24. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-953X (Electronic) Linking ISSN: 09699961 NLM ISO Abbreviation: Neurobiol Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: San Diego, CA : Academic Press Original Publication: Oxford : Blackwell Science, c1994- |
| مواضيع طبية MeSH: | Autism Spectrum Disorder* , Brain* , Induced Pluripotent Stem Cells* , Models, Neurological* , Neural Stem Cells*, Cells, Cultured ; Humans |
| مستخلص: | Autism Spectrum Disorders (ASDs) are a group of neurodevelopmental disorders that influence social skills, involving communication, interaction, and behavior, usually with repetitive and restrictive manners. Due to the variety of genes involved in ASDs and several possible environmental factors influence, there is still no answer to what really causes syndromic and non-syndromic types of ASDs, usually affecting each individual in a unique way. However, we know that the mechanism underlying ASDs involves brain functioning. The human brain is a complex structure composed of close to 100 billion cells, which is a big challenge to study counting just with post mortem tissue investigation or genetic approaches. Therefore, human induced pluripotent stem cells (iPSC) technology has been used as a tool to produce viable cells for understanding a working brain. Taking advantage of patient-derived stem cells, researchers are now able to generate neurons, glial cells and brain organoids in vitro to model ASDs. In this review we report data from different studies showing how iPSCs have been a critical tool to study the different phenotypes of ASDs. (Copyright © 2019 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Autism Spectrum Disorders; Brain cells; Brain organoid; Disease modeling; Stem cells; iPSC |
| تواريخ الأحداث: | Date Created: 20190527 Date Completed: 20200324 Latest Revision: 20200324 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.nbd.2019.104483 |
| PMID: | 31129084 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1095-953X |
|---|---|
| DOI: | 10.1016/j.nbd.2019.104483 |