دورية أكاديمية
أعرض في EDS

Robotically-Assisted Sonic Therapy for Renal Ablation in a Live Porcine Model: Initial Preclinical Results.

التفاصيل البيبلوغرافية
العنوان: Robotically-Assisted Sonic Therapy for Renal Ablation in a Live Porcine Model: Initial Preclinical Results.
المؤلفون: Knott EA; Department of Radiology, University of Wisconsin, 600 Highland Ave., Madison, WI 53024. Electronic address: emilyknott13@gmail.com., Swietlik JF; Department of Radiology, University of Wisconsin, 600 Highland Ave., Madison, WI 53024., Longo KC; Department of Radiology, University of Wisconsin, 600 Highland Ave., Madison, WI 53024., Watson RF; Department of Pathology, University of Wisconsin, 600 Highland Ave., Madison, WI 53024., Green CM; Department of Statistics, University of Wisconsin, 600 Highland Ave., Madison, WI 53024., Abel EJ; Department of Radiology, University of Wisconsin, 600 Highland Ave., Madison, WI 53024; Department of Urology, University of Wisconsin, 600 Highland Ave., Madison, WI 53024., Lubner MG; Department of Radiology, University of Wisconsin, 600 Highland Ave., Madison, WI 53024., Hinshaw JL; Department of Radiology, University of Wisconsin, 600 Highland Ave., Madison, WI 53024., Smolock AR; Department of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania., Xu Z; Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan., Lee FT Jr; Department of Radiology, University of Wisconsin, 600 Highland Ave., Madison, WI 53024; Department of Urology, University of Wisconsin, 600 Highland Ave., Madison, WI 53024; Department of Biomedical Engineering, University of Wisconsin, 600 Highland Ave., Madison, WI 53024., Ziemlewicz TJ; Department of Radiology, University of Wisconsin, 600 Highland Ave., Madison, WI 53024.
المصدر: Journal of vascular and interventional radiology : JVIR [J Vasc Interv Radiol] 2019 Aug; Vol. 30 (8), pp. 1293-1302. Date of Electronic Publication: 2019 May 23.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Society of Cardiovascular and Interventional Radiology Country of Publication: United States NLM ID: 9203369 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-7732 (Electronic) Linking ISSN: 10510443 NLM ISO Abbreviation: J Vasc Interv Radiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Reston, Va. : Society of Cardiovascular and Interventional Radiology, c1990-
مواضيع طبية MeSH: High-Intensity Focused Ultrasound Ablation*/adverse effects , Robotic Surgical Procedures*/adverse effects, Kidney/*surgery, Animals ; Feasibility Studies ; Kidney/diagnostic imaging ; Kidney/pathology ; Models, Animal ; Multidetector Computed Tomography ; Operative Time ; Sus scrofa ; Time Factors
مستخلص: Purpose: To demonstrate the feasibility of Robotically Assisted Sonic Therapy (RAST)-a noninvasive and nonthermal focused ultrasound therapy based on histotripsy-for renal ablation in a live porcine model.
Materials and Methods: RAST ablations (n = 11) were performed in 7 female swine: 3 evaluated at 1 week (acute) and 4 evaluated at 4 weeks (chronic). Treatment groups were acute bilateral (3 swine, 6 ablations with immediate computed tomography [CT] and sacrifice); chronic single kidney (3 swine, 3 ablations; CT at day 0, week 1, and week 4 after treatment, followed by sacrifice); and chronic bilateral (1 swine, 2 ablations). Treatments were performed using a prototype system (VortxRx; HistoSonics, Inc) and targeted a 2.5-cm-diameter sphere in the lower pole of each kidney, intentionally including the central collecting system.
Results: Mean treatment time was 26.4 minutes. Ablations had a mean diameter of 2.4 ± 0.3 cm, volume of 8.5 ± 2.4 cm 3 , and sphericity index of 1.00. Median ablation volume decreased by 96.1% over 4 weeks. Histology demonstrated complete lysis with residual blood products inside the ablation zone. Temporary collecting system obstruction by thrombus was observed in 4/11 kidneys (2 acute and 2 chronic) and resolved by 1 week. There were no urinary leaks, main vessel thromboses, or adjacent organ injuries on imaging or necropsy.
Conclusions: In this normal porcine model, renal RAST demonstrated complete histologic destruction of the target renal tissue while sparing the urothelium.
(Published by Elsevier Inc.)
التعليقات: Comment in: J Urol. 2020 Jan;203(1):14. (PMID: 31618161)
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معلومات مُعتمدة: R01 CA211217 United States CA NCI NIH HHS
تواريخ الأحداث: Date Created: 20190528 Date Completed: 20200302 Latest Revision: 20240217
رمز التحديث: 20240217
مُعرف محوري في PubMed: PMC6925588
DOI: 10.1016/j.jvir.2019.01.023
PMID: 31130365
قاعدة البيانات: MEDLINE
الوصف
تدمد:1535-7732
DOI:10.1016/j.jvir.2019.01.023