التفاصيل البيبلوغرافية
| العنوان: |
Mechano-biological model of glioblastoma cells in response to osmotic stress. |
| المؤلفون: |
Pozzi G; MOX Laboratory, Department of Mathematics, Politecnico di Milano, Italy., Marchesi S; MOX Laboratory, Department of Mathematics, Politecnico di Milano, Italy.; IFOM, the FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy., Scita G; IFOM, the FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy., Ambrosi D; DISMA, Dipartimento di Scienze Matematiche 'G.L. Lagrange', Politecnico di Torino, Italy., Ciarletta P; MOX Laboratory, Department of Mathematics, Politecnico di Milano, Italy. |
| المصدر: |
Mathematical biosciences and engineering : MBE [Math Biosci Eng] 2019 Apr 01; Vol. 16 (4), pp. 2795-2810. |
| نوع المنشور: |
Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: American Institute of Mathematical Sciences;; _b Beihang University Country of Publication: United States NLM ID: 101197794 Publication Model: Print Cited Medium: Internet ISSN: 1551-0018 (Electronic) Linking ISSN: 15471063 NLM ISO Abbreviation: Math Biosci Eng Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Springfield, MO, USA : [S.l.] : American Institute of Mathematical Sciences; Beihang University |
| مواضيع طبية MeSH: |
Osmotic Pressure*, Brain Neoplasms/*physiopathology , Glioblastoma/*physiopathology, Astrocytes/metabolism ; Cell Division ; Cell Line, Tumor ; Cell Proliferation ; Computer Simulation ; Cytoskeleton/metabolism ; Dextrans/chemistry ; Elasticity ; Humans ; Microscopy ; Models, Biological ; Osmosis ; Pressure ; Spheroids, Cellular/cytology ; Stress, Physiological ; Treatment Outcome |
| مستخلص: |
This work investigates the mechano-biological features of cells cultured in monolayers in response to different osmotic conditions. In-vitro experiments have been performed to quantify the long-term effects of prolonged osmotic stresses on the morphology and proliferation capacity of glioblastoma cells. The experimental results highlight that both hypotonic and hypertonic conditions affect the proliferative rate of glioblastoma cells on different cell cycle phases. Moreover, glioblastoma cells in hypertonic conditions display a flattened and elongated shape. The latter effect is explained using a nonlinear elastic model for the single cell. Due to a crossover between the free energy contributions related to the cytosol and the cytoskeletal fibers, a critical osmotic stress determines a morphological transition from a uniformly compressed to an elongated shape. |
| فهرسة مساهمة: |
Keywords: biomathematics; cancer model; glioblastoma; mechano-biology; osmotic stress |
| المشرفين على المادة: |
0 (Dextrans) |
| تواريخ الأحداث: |
Date Created: 20190530 Date Completed: 20200108 Latest Revision: 20200108 |
| رمز التحديث: |
20240628 |
| DOI: |
10.3934/mbe.2019139 |
| PMID: |
31137238 |
| قاعدة البيانات: |
MEDLINE |
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