دورية أكاديمية
Formant Frequencies, Cephalometric Measures, and Pharyngeal Airway Width in Adults With Congenital, Isolated, and Untreated Growth Hormone Deficiency.
| العنوان: | Formant Frequencies, Cephalometric Measures, and Pharyngeal Airway Width in Adults With Congenital, Isolated, and Untreated Growth Hormone Deficiency. |
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| المؤلفون: | Reinheimer DM; Postgraduate Program in Dentistry, Federal University of Sergipe, Aracaju, Brazil., Andrade BMR; Division of Speech Therapy, Federal University of Sergipe, Aracaju, Brazil., Nascimento JKF; Postgraduate Program in Dentistry, Federal University of Sergipe, Aracaju, Brazil., Fonte JBM; Postgraduate Program in Dentistry, Federal University of Sergipe, Aracaju, Brazil., Araújo IMP; Postgraduate Program in Dentistry, Federal University of Sergipe, Aracaju, Brazil., Martins-Filho PRS; Investigative Pathology Laboratory, Federal University of Sergipe, Aracaju, Brazil., Salvatori R; Division of Endocrinology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland., Valença EHO; Division of Speech Therapy, Federal University of Sergipe, Aracaju, Brazil., Oliveira AHA; Postgraduate Program in Dentistry, Federal University of Sergipe, Aracaju, Brazil., Aguiar-Oliveira MH; Division of Endocrinology, Federal University of Sergipe, Aracaju, Brazil. Electronic address: herminio@infonet.com.br., Oliveira-Neto LA; Postgraduate Program in Dentistry, Federal University of Sergipe, Aracaju, Brazil. |
| المصدر: | Journal of voice : official journal of the Voice Foundation [J Voice] 2021 Jan; Vol. 35 (1), pp. 61-68. Date of Electronic Publication: 2019 May 28. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mosby Country of Publication: United States NLM ID: 8712262 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4588 (Electronic) Linking ISSN: 08921997 NLM ISO Abbreviation: J Voice Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2003- : St. Louis, MO : Mosby Original Publication: [New York, N.Y.] : Raven Press, 1987- |
| مواضيع طبية MeSH: | Dwarfism, Pituitary*, Adult ; Cephalometry ; Growth Hormone ; Humans ; Mandible/diagnostic imaging ; Pharynx/diagnostic imaging |
| مستخلص: | Objective: Adult subjects with isolated growth hormone deficiency (IGHD) due to a mutation in the growth hormone releasing hormone receptor gene exhibit higher values formant frequencies. In normal subjects, a significant negative association between the formant frequencies and the reduction of linear craniofacial measurements, especially of maxilla and mandible, has been reported. This suggests smaller pharyngeal width, despite low prevalence of obstructive sleep apnea syndrome. Here we evaluate their pharyngeal airway width, its correlation with vowel formant frequencies, and the correlation between them and the craniofacial measures. Subjects and Methods: A two-step protocol was performed. In the first case-control experiment, aimed to assess the pharyngeal width, we compared nine adult IGHD and 36 normal statured controls. Both upper and lower pharyngeal widths were measured. The second step (assessment of pharyngeal width) was performed only in the IGHD group. Results: Upper and lower pharyngeal widths were similar in IGHD and controls. In IGHD subjects, the lower pharyngeal width exhibited a negative correlation with F1 [a] and a positive correlation with mandibular length. There were negative correlations between F1 and F2 with linear and positive correlations with the angular measures. Conclusions: Pharyngeal airway width is not reduced in adults with congenital, untreated lifetime IGHD, contributing to the low prevalence of obstructive sleep apnea syndrome. The formant frequencies relate more with cephalometric measurements than with the pharyngeal airway width. These findings exemplify the consequences of lifetime IGHD on osseous and nonosseous growth. (Copyright © 2019 The Voice Foundation. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Formant frequencies; Growth hormone; Mandible; Maxilla; Pharynx; Voice |
| المشرفين على المادة: | 9002-72-6 (Growth Hormone) |
| تواريخ الأحداث: | Date Created: 20190601 Date Completed: 20210728 Latest Revision: 20210728 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.jvoice.2019.04.014 |
| PMID: | 31147205 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1873-4588 |
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| DOI: | 10.1016/j.jvoice.2019.04.014 |