[Exploring Molecular Targets for Epilepsy Treatment from the Perspective of Neuronal Homeostasis].

التفاصيل البيبلوغرافية
العنوان:	[Exploring Molecular Targets for Epilepsy Treatment from the Perspective of Neuronal Homeostasis].
المؤلفون:	Nagai T; Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine., Shan W; Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine., Yamada K; Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine.
المصدر:	Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan [Yakugaku Zasshi] 2019; Vol. 139 (6), pp. 923-929.
نوع المنشور:	Journal Article; Review
اللغة:	Japanese
بيانات الدورية:	Publisher: Nihon Yakugakkai Country of Publication: Japan NLM ID: 0413613 Publication Model: Print Cited Medium: Internet ISSN: 1347-5231 (Electronic) Linking ISSN: 00316903 NLM ISO Abbreviation: Yakugaku Zasshi Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Tokyo : Nihon Yakugakkai
مواضيع طبية MeSH:	Homeostasis* , Molecular Targeted Therapy, Basic Helix-Loop-Helix Transcription Factors/physiology , Brain/physiology , Epilepsy/drug therapy , Epilepsy/etiology , Neurons/physiology, Animals ; Basic Helix-Loop-Helix Transcription Factors/deficiency ; Disease Models, Animal ; Epilepsy/genetics ; Humans ; Kindling, Neurologic ; Mice ; Synapses/physiology
مستخلص:	Brain function is controlled by the balance between the excitatory and inhibitory systems. If this balance is disrupted and the excitatory system dominates, convulsions or epileptic seizures are induced. Neuronal hyperexcitability in the brain leads to marked changes in the function of the neurons, which adversely affect the stability of the neural network. Many of the currently used antiepileptic drugs are symptomatic treatments that suppress the electrical hyperexcitability of the cerebrum. Although patients with epilepsy should continuously take antiepileptic drugs to control their seizures, approximately 20% of patients are drug resistant. The brain has the ability to control neuronal functions within acceptable limits while it maintains the amount of synaptic inputs that form the basis of information accumulation. Neuronal self-regulation is known as homeostatic scaling by which the intensity of all excitatory synapses is suppressed when neuronal excitability is increased. However, the molecular mechanisms of homeostatic scaling and their pathophysiological significance in vivo remain unclear. Repeated treatment with a subconvulsive dosage of pentylenetetrazol (PTZ), a γ-aminobutyric acid (GABA) A receptor antagonist, is known to induce kindling in mice, which is a common animal model used to study epilepsy. We found that PTZ-induced kindling was potentiated in mice deficient in the transcription factor neuronal PAS domain protein 4 (Npas4), the expression of which is immediately induced in response to neuronal activity. At this symposium, we will discuss the possibility of Npas4 as a novel target molecule for epilepsy treatment.
فهرسة مساهمة:	Keywords: animal model; epilepsy; homeostatic scaling; neuronal PAS domain protein 4
المشرفين على المادة:	0 (Basic Helix-Loop-Helix Transcription Factors) 0 (Npas4 protein, mouse)
تواريخ الأحداث:	Date Created: 20190604 Date Completed: 20190708 Latest Revision: 20190708
رمز التحديث:	20240513
DOI:	10.1248/yakushi.18-00213-4
PMID:	31155537
قاعدة البيانات:	MEDLINE

الوصف
تدمد:	1347-5231
DOI:	10.1248/yakushi.18-00213-4