دورية أكاديمية
Effectiveness of steroid therapy for pancreatic cysts complicating autoimmune pancreatitis and management strategy for cyst-related complications.
| العنوان: | Effectiveness of steroid therapy for pancreatic cysts complicating autoimmune pancreatitis and management strategy for cyst-related complications. |
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| المؤلفون: | Kuraishi Y; Department of Gastroenterology, Shinshu University School of Medicine , Matsumoto , Japan., Watanabe T; Department of Gastroenterology, Shinshu University School of Medicine , Matsumoto , Japan., Muraki T; Department of Gastroenterology, North Alps Medical Center Azumi Hospital , Ikeda , Japan., Ashihara N; Department of Gastroenterology, Shinshu University School of Medicine , Matsumoto , Japan., Ozawa M; Department of Gastroenterology, Shinshu University School of Medicine , Matsumoto , Japan., Nakamura A; Department of Gastroenterology, Shinshu University School of Medicine , Matsumoto , Japan., Kanai K; Department of Gastroenterology, Shinshu University School of Medicine , Matsumoto , Japan., Hamano H; Department of Gastroenterology, Shinshu University School of Medicine , Matsumoto , Japan., Kawa S; Department of Internal Medicine, Matsumoto Dental University , Shiojiri , Japan. |
| المصدر: | Scandinavian journal of gastroenterology [Scand J Gastroenterol] 2019 Jun; Vol. 54 (6), pp. 773-779. Date of Electronic Publication: 2019 Jun 04. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 0060105 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1502-7708 (Electronic) Linking ISSN: 00365521 NLM ISO Abbreviation: Scand J Gastroenterol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Oslo : Universitetsforlager |
| مواضيع طبية MeSH: | Autoimmune Pancreatitis/*complications , Pancreatic Cyst/*drug therapy , Pancreatic Cyst/*etiology , Steroids/*therapeutic use, Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Japan ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Retrospective Studies ; Risk Factors ; Treatment Outcome |
| مستخلص: | Objectives: Autoimmune pancreatitis (AIP) sometimes becomes complicated with pancreatic cysts, although their detailed characteristics and management strategy have not been fully determined. We aimed to clarify the efficiency of steroid therapy and the risk factors for cyst formation and cyst-related complications. Methods: One hundred sixty-three AIP patients were retrospectively analyzed for relevant factors of cyst formation. We compared subjects with and without steroids to evaluate drug effectiveness on cyst size change and investigated the factors associated with cyst-related complications. Results: Thirty-two patients (19.6%) had complicating pancreatic cyst formation, and 40 cystic lesions of ≥10 mm in size were detected. Multivariate analysis revealed a drinking habit, abdominal/back pain, and elevated serum amylase to be significantly associated with cyst formation. Steroid-treated cysts became significantly reduced in size in the short-term and disappeared significantly more frequently within 1-year as compared with non-treated ones, which was confirmed by multivariate analysis. Six of 40 cysts exhibited cyst-related complications significantly associated with multilocular morphology and larger size. Conclusions: Steroid therapy is an effective choice for cysts developing in AIP to promote the release of pancreatic juice stasis. Larger lesions with multilocular morphology should be monitored closely for cyst-related complications and be considered strong candidates for steroid therapy. |
| فهرسة مساهمة: | Keywords: Autoimmune pancreatitis; cyst; cyst-related complications; pancreatic juice stasis; steroid therapy |
| المشرفين على المادة: | 0 (Steroids) |
| تواريخ الأحداث: | Date Created: 20190606 Date Completed: 20200721 Latest Revision: 20200721 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1080/00365521.2019.1623307 |
| PMID: | 31164010 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1502-7708 |
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| DOI: | 10.1080/00365521.2019.1623307 |