دورية أكاديمية
Antibacterial and antibiotic-modifying activities of fractions and compounds from Albizia adianthifolia against MDR Gram-negative enteric bacteria.
العنوان: | Antibacterial and antibiotic-modifying activities of fractions and compounds from Albizia adianthifolia against MDR Gram-negative enteric bacteria. |
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المؤلفون: | Tchinda CF; Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.; Department of Biochemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon., Sonfack G; Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Simo IK; Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Çelik İ; Department of Chemistry, Faculty of Science, Eskişehir Technical University, 26470, Eskişehir, Turkey., Voukeng IK; Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon., Nganou BK; Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Bitchagno GTM; Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Ekti SF; Department of Chemistry, Faculty of Science, Eskişehir Technical University, 26470, Eskişehir, Turkey., Tene M; Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Tane P; Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Beng VP; Department of Biochemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon., Kuete V; Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon. kuetevictor@yahoo.fr. |
المصدر: | BMC complementary and alternative medicine [BMC Complement Altern Med] 2019 Jun 06; Vol. 19 (1), pp. 120. Date of Electronic Publication: 2019 Jun 06. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101088661 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-6882 (Electronic) Linking ISSN: 14726882 NLM ISO Abbreviation: BMC Complement Altern Med Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: London : BioMed Central, [2001-2019] |
مواضيع طبية MeSH: | Drug Synergism*, Albizzia/*chemistry , Anti-Bacterial Agents/*isolation & purification , Phytochemicals/*isolation & purification, Drug Resistance, Multiple, Bacterial ; Microbial Sensitivity Tests ; Phytochemicals/pharmacology |
مستخلص: | Background: Albizia adianthifolia (Schum.) is medicinally used in Cameroon to manage bronchitis and skin diseases. Our previous study documented the antibacterial potential of its roots' methanol extract. In this study, methanol roots extract was subjected to chromatography techniques and fractions (AARa and AARb), sub-fractions (AARa1-4, AARb1-2 and AARb11-14) together with isolated phytochemicals were assessed for their antimicrobial as well as their antibiotic-potentiating effects towards Gram-negative multidrug resistant (MDR) bacteria. Methods: The antibacterial activities of the samples (determination of Minimal Inhibitory « MIC » and Minimal Bactericidal Concentration « MBC ») were determined by the modified rapid p-iodonitrotetrazolium chloride (INT) colorimetric assay, as well as those of antibiotics in association with the compounds. Column chromatography was applied to isolate phytochemicals from roots extract and their chemical structures were determined using spectroscopic techniques. Results: The phytochemicals isolated were stearic acid (1), a mixture (1:1) of stigmasterol and β-sitosterol (2 + 3), β-sitosterol 3-O-β- Conclusion: The present study provides information on the possible use of Albizia adianthifolia and its constituents in the control of Gram-negative infections including MDR phenotypes. |
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معلومات مُعتمدة: | 1306F110 Anadolu Üniversitesi |
فهرسة مساهمة: | Keywords: Albizia adianthifolia; Antibiotic modifying activity; Fabaceae; Multi-drug resistance; Phytochemicals |
المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Phytochemicals) |
تواريخ الأحداث: | Date Created: 20190608 Date Completed: 20190905 Latest Revision: 20200225 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC6554897 |
DOI: | 10.1186/s12906-019-2537-1 |
PMID: | 31170979 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1472-6882 |
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DOI: | 10.1186/s12906-019-2537-1 |