دورية أكاديمية
أعرض في EDS

Antibacterial and antibiotic-modifying activities of fractions and compounds from Albizia adianthifolia against MDR Gram-negative enteric bacteria.

التفاصيل البيبلوغرافية
العنوان: Antibacterial and antibiotic-modifying activities of fractions and compounds from Albizia adianthifolia against MDR Gram-negative enteric bacteria.
المؤلفون: Tchinda CF; Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.; Department of Biochemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon., Sonfack G; Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Simo IK; Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Çelik İ; Department of Chemistry, Faculty of Science, Eskişehir Technical University, 26470, Eskişehir, Turkey., Voukeng IK; Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon., Nganou BK; Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Bitchagno GTM; Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Ekti SF; Department of Chemistry, Faculty of Science, Eskişehir Technical University, 26470, Eskişehir, Turkey., Tene M; Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Tane P; Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Beng VP; Department of Biochemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon., Kuete V; Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon. kuetevictor@yahoo.fr.
المصدر: BMC complementary and alternative medicine [BMC Complement Altern Med] 2019 Jun 06; Vol. 19 (1), pp. 120. Date of Electronic Publication: 2019 Jun 06.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101088661 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-6882 (Electronic) Linking ISSN: 14726882 NLM ISO Abbreviation: BMC Complement Altern Med Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-2019]
مواضيع طبية MeSH: Drug Synergism*, Albizzia/*chemistry , Anti-Bacterial Agents/*isolation & purification , Phytochemicals/*isolation & purification, Drug Resistance, Multiple, Bacterial ; Microbial Sensitivity Tests ; Phytochemicals/pharmacology
مستخلص: Background: Albizia adianthifolia (Schum.) is medicinally used in Cameroon to manage bronchitis and skin diseases. Our previous study documented the antibacterial potential of its roots' methanol extract. In this study, methanol roots extract was subjected to chromatography techniques and fractions (AARa and AARb), sub-fractions (AARa1-4, AARb1-2 and AARb11-14) together with isolated phytochemicals were assessed for their antimicrobial as well as their antibiotic-potentiating effects towards Gram-negative multidrug resistant (MDR) bacteria.
Methods: The antibacterial activities of the samples (determination of Minimal Inhibitory « MIC » and Minimal Bactericidal Concentration « MBC ») were determined by the modified rapid p-iodonitrotetrazolium chloride (INT) colorimetric assay, as well as those of antibiotics in association with the compounds. Column chromatography was applied to isolate phytochemicals from roots extract and their chemical structures were determined using spectroscopic techniques.
Results: The phytochemicals isolated were stearic acid (1), a mixture (1:1) of stigmasterol and β-sitosterol (2 +  3), β-sitosterol 3-O-β- D -glucopyranoside (4), palmatin (5), homomangiferin (6) and mangiferin (7). Fraction AARa exhibited selective inhibitory effects whilst all tested bacteria were inhibited by AARb in MIC ranges of 8 to 1024 μg/mL. Sub-fractions AARb1-2 had MIC values between 8 μg/mL and 1024 μg/mL on all tested bacteria. Phytochemicals 4, 2 +  3 and 7 inhibited the growth of 54.54% (6/11), 45.45% (5/11) and 27.27% (3/11) tested bacterial strains, respectively. When tested with an efflux pumps inhibitor (Phenylalanine-Arginine-β-Naphthylamide or PAβN), the inhibitory effects of compounds 2 + 3 and 4 increased towards all the tested bacteria. In association with erythromycin (ERY), streptomycin (STR) and tetracycline (TET), compounds 2 + 3 and 4 had the most significant synergistic activity on the seven selected bacteria.
Conclusion: The present study provides information on the possible use of Albizia adianthifolia and its constituents in the control of Gram-negative infections including MDR phenotypes.
References: Clin Microbiol Rev. 1999 Oct;12(4):564-82. (PMID: 10515903)
Biochem Biophys Res Commun. 2000 Aug 2;274(2):496-9. (PMID: 10913366)
Pharmazie. 2002 Oct;57(10):705-8. (PMID: 12426954)
Phytochemistry. 2003 Feb;62(3):389-98. (PMID: 12620352)
J Nat Prod. 2003 Mar;66(3):372-7. (PMID: 12662095)
Bioorg Med Chem. 2004 Sep 1;12(17):4725-34. (PMID: 15358299)
Pathol Biol (Paris). 2004 Dec;52(10):607-16. (PMID: 15596311)
Biochem Biophys Res Commun. 2005 Mar 25;328(4):1113-8. (PMID: 15707992)
Can J Microbiol. 2005 Jul;51(7):541-7. (PMID: 16175202)
Biochem Pharmacol. 2006 Mar 30;71(7):910-8. (PMID: 16427026)
Int J Antimicrob Agents. 2007 Jun;29(6):630-6. (PMID: 17306965)
J Ethnopharmacol. 2007 Oct 8;114(1):54-60. (PMID: 17766070)
Biochim Biophys Acta. 2009 May;1794(5):826-33. (PMID: 19150515)
J Ethnopharmacol. 2009 Jul 30;124(3):556-61. (PMID: 19450673)
Antimicrob Agents Chemother. 2010 May;54(5):1749-52. (PMID: 20160051)
Planta Med. 2010 Oct;76(14):1479-91. (PMID: 20533165)
Pharmacogn Mag. 2010 Jan;6(21):1-4. (PMID: 20548928)
Environ Toxicol Pharmacol. 2011 Sep;32(2):162-7. (PMID: 21843795)
BMC Res Notes. 2012 Jun 15;5:299. (PMID: 22709668)
BMC Complement Altern Med. 2012 Jul 18;12:99. (PMID: 22809287)
PLoS One. 2013;8(3):e60666. (PMID: 23544160)
BMC Complement Altern Med. 2013 Jul 25;13:190. (PMID: 23885762)
Molecules. 2014 Aug 29;19(9):13332-41. (PMID: 25178058)
BMC Complement Altern Med. 2015 Jun 30;15:206. (PMID: 26122102)
BMC Complement Altern Med. 2015 Dec 30;15:453. (PMID: 26715029)
J Ethnopharmacol. 2016 Aug 22;190:100-5. (PMID: 27267830)
BMC Complement Altern Med. 2016 Jul 07;16:193. (PMID: 27386848)
BMC Complement Altern Med. 2016 Oct 10;16(1):388. (PMID: 27724917)
Saudi J Biol Sci. 2017 May;24(4):950-955. (PMID: 28490970)
BMC Complement Altern Med. 2018 Jan 15;18(1):15. (PMID: 29334931)
Planta Med. 1998 Dec;64(8):711-3. (PMID: 9933989)
معلومات مُعتمدة: 1306F110 Anadolu Üniversitesi
فهرسة مساهمة: Keywords: Albizia adianthifolia; Antibiotic modifying activity; Fabaceae; Multi-drug resistance; Phytochemicals
المشرفين على المادة: 0 (Anti-Bacterial Agents)
0 (Phytochemicals)
تواريخ الأحداث: Date Created: 20190608 Date Completed: 20190905 Latest Revision: 20200225
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6554897
DOI: 10.1186/s12906-019-2537-1
PMID: 31170979
قاعدة البيانات: MEDLINE
الوصف
تدمد:1472-6882
DOI:10.1186/s12906-019-2537-1