دورية أكاديمية
أعرض في EDS

Discovery of biomarkers for the presence and progression of left ventricular diastolic dysfunction and HEart faiLure with Preserved ejection Fraction in patients at risk for cardiovascular disease: rationale and design of the HELPFul case-cohort study in a Dutch cardiology outpatient clinic.

التفاصيل البيبلوغرافية
العنوان: Discovery of biomarkers for the presence and progression of left ventricular diastolic dysfunction and HEart faiLure with Preserved ejection Fraction in patients at risk for cardiovascular disease: rationale and design of the HELPFul case-cohort study in a Dutch cardiology outpatient clinic.
المؤلفون: Valstar GB; Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Bots SH; Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Groepenhoff F; Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Gohar A; Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Rutten FH; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Leiner T; Department of Radiology, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands., Cramer MJM; Department of Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Teske AJ; Department of Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Suciadi LP; Department of Cardiology, Siloam Heart Institute, Siloam Hospital KebonJeruk, Jakarta, Indonesia., Menken R; Cardiologie Centra Nederland, Utrecht, The Netherlands., Pasterkamp G; Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Asselbergs FW; Department of Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.; Institute of Cardiovascular Science and Institute of Health Informatics, Faculty of Population Health Sciences, University College London, London, United Kingdom., Hofstra L; Cardiologie Centra Nederland, Utrecht, The Netherlands.; Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands., Bots ML; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., den Ruijter HM; Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
المصدر: BMJ open [BMJ Open] 2019 Jun 05; Vol. 9 (6), pp. e028408. Date of Electronic Publication: 2019 Jun 05.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BMJ Publishing Group Ltd, 2011-
مواضيع طبية MeSH: Disease Progression*, Cardiology/*methods , Heart Failure/*diagnosis , Heart Failure/*physiopathology , Ventricular Dysfunction, Left/*diagnosis , Ventricular Dysfunction, Left/*physiopathology, Ambulatory Care Facilities ; Biomarkers ; Carotid Intima-Media Thickness/statistics & numerical data ; Cohort Studies ; Echocardiography/statistics & numerical data ; Exercise Test/statistics & numerical data ; Female ; Humans ; Male ; Middle Aged ; Netherlands ; Prospective Studies ; Risk
مستخلص: Introduction: Left ventricular diastolic dysfunction (LVDD) is a common condition in both sexes that may deteriorate into heart failure (HF) with preserved ejection fraction (pEF), although this seems to happen more often in women than in men. Both LVDD and HFpEF often go unrecognised, necessitating the discovery of biomarkers that aid both the identification of individuals with LVDD at risk of developing HF and identification of individuals most likely to benefit from treatment.
Methods and Analysis: HELPFul is an ongoing case-cohort study at a Dutch cardiology outpatient clinic enrolling patients aged 45 years and older without history of cardiovascular disease, who were referred by the general practitioner for cardiac evaluation. We included a random sample of patients and enriched the cohort with cases (defined as an E/e' ≥8 measured with echocardiography). Information about medical history, cardiovascular risk factors, electrocardiography, echocardiography, exercise test performance, common carotid intima-media thickness measurement and standard cardiovascular biomarkers was obtained from the routine care data collected by the cardiology outpatient clinic. Study procedure consists of extensive venous blood collection for biobanking and additional standardised questionnaires. Follow-up will consist of standardised questionnaires by mail and linkage to regional and national registries. We will perform cardiac magnetic resonance imaging and coronary CT angiography in a subgroup of patients to investigate the extent of macrovascular and microvascular coronary disease.
Ethics and Dissemination: The study protocol was approved by the Institutional Review Board of the University Medical Center Utrecht. Results will be disseminated through national and international conferences and in peer-reviewed journals in cardiovascular disease.
Trial Registration: NTR6016;Pre-results.
Competing Interests: Competing interests: None declared.
(© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
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فهرسة مساهمة: Keywords: biobank; biomarkers; heart failure; heart failure with preserved ejection fraction; left ventricular diastolic dysfunction; study protocol
سلسلة جزيئية: NTR NTR6016
المشرفين على المادة: 0 (Biomarkers)
تواريخ الأحداث: Date Created: 20190608 Date Completed: 20200615 Latest Revision: 20200615
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC6561429
DOI: 10.1136/bmjopen-2018-028408
PMID: 31171553
قاعدة البيانات: MEDLINE
الوصف
تدمد:2044-6055
DOI:10.1136/bmjopen-2018-028408