دورية أكاديمية
Serum leptin levels correlate negatively with the capacity of vitamin D to modulate the in vitro cytokines production by CD4 + T cells in asthmatic patients.
| العنوان: | Serum leptin levels correlate negatively with the capacity of vitamin D to modulate the in vitro cytokines production by CD4 + T cells in asthmatic patients. |
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| المؤلفون: | Dias ASO; Department of Microbiology and Parasitology, Federal University of the State of Rio de Janeiro, Brazil; Post-graduate Program in Microbiology, University of the State of Rio de Janeiro, Brazil., Santos ICL; Department of Microbiology and Parasitology, Federal University of the State of Rio de Janeiro, Brazil., Delphim L; Department of Microbiology and Parasitology, Federal University of the State of Rio de Janeiro, Brazil., Fernandes G; Department of Microbiology and Parasitology, Federal University of the State of Rio de Janeiro, Brazil., Endlich LR; Department of Microbiology and Parasitology, Federal University of the State of Rio de Janeiro, Brazil., Cafasso MOSD; Department of Microbiology and Parasitology, Federal University of the State of Rio de Janeiro, Brazil., Maranhão AL; Pulmonology Service, Federal University of the State of Rio de Janeiro, Brazil., da Silva SR; Pulmonology Service, Federal University of the State of Rio de Janeiro, Brazil., Andrade RM; Department of General Medicine Department, Federal University of the State of Rio de Janeiro, Brazil., Agrawal A; Department of Medicine, University of California, Irvine, CA, USA., Linhares UC; Department of Morphological Sciences, Federal University of the State of Rio de Janeiro, Brazil., Bento CAM; Department of Microbiology and Parasitology, Federal University of the State of Rio de Janeiro, Brazil; Post-graduate Program in Microbiology, University of the State of Rio de Janeiro, Brazil. Electronic address: cbento@unirio.br. |
| المصدر: | Clinical immunology (Orlando, Fla.) [Clin Immunol] 2019 Aug; Vol. 205, pp. 93-105. Date of Electronic Publication: 2019 Jun 04. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: United States NLM ID: 100883537 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-7035 (Electronic) Linking ISSN: 15216616 NLM ISO Abbreviation: Clin Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Orlando, FL : Academic Press, c1999- |
| مواضيع طبية MeSH: | Asthma/*immunology , CD4-Positive T-Lymphocytes/*immunology , Cytokines/*immunology , Hypersensitivity/*immunology , Leptin/*metabolism , Obesity/*metabolism, Adult ; Asthma/metabolism ; CD4-Positive T-Lymphocytes/drug effects ; Calcitriol/pharmacology ; Cytokines/drug effects ; Female ; Humans ; Hypersensitivity/metabolism ; Immunoglobulin E/immunology ; In Vitro Techniques ; Interleukin-10/immunology ; Interleukin-17/immunology ; Interleukin-5/immunology ; Interleukin-6/immunology ; Male ; Middle Aged ; Severity of Illness Index ; Th1 Cells/drug effects ; Th1 Cells/immunology ; Th17 Cells/drug effects ; Th17 Cells/immunology ; Vitamin D/metabolism ; Vitamins/pharmacology ; Young Adult |
| مستخلص: | Both obesity and low vitamin D levels have been associated with allergic asthma (AA) severity. In the present study, severity of AA was associated with obesity but to the in vitro IgE production. In those patients, higher levels of IL-5, IL-6 and IL-17 were quantified in CD4 + T-cell cultures as compared with patients with mild and moderate AA. In addition, the lowest IL-10 levels were detected in the cell cultures from patients with a worse prognosis. Interestingly, the occurrence of AA elevates the plasma levels of leptin, and this adipokine was positively correlated with the release of IL-5, IL-6 and IL-17, but inversely correlated with IL-10 production, by CD4 + T-cells from patients. In AA-derived CD4 + T-cell cultures, 1,25(OH)2D3 was less efficient at inhibiting IL-5, IL-6 and IL-17 production, and up regulating IL-10 release, as those from healthy subjects. Interestingly, the in vitro immunomodulatory effects of vitamin D were inversely correlated with serum leptin levels. In summary, our findings suggested that obesity, probably due to the overproduction of leptin, negatively impacts AA as it favors imbalance between Th2/Th17 and regulatory phenotypes. The deleterious effects of leptin may also be due to its ability to counter-regulate the immunosuppressive effects of vitamin D. (Copyright © 2019 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: IgE; Leptin; Th17; Th2; Vitamin D |
| المشرفين على المادة: | 0 (Cytokines) 0 (Interleukin-17) 0 (Interleukin-5) 0 (Interleukin-6) 0 (Leptin) 0 (Vitamins) 130068-27-8 (Interleukin-10) 1406-16-2 (Vitamin D) 37341-29-0 (Immunoglobulin E) FXC9231JVH (Calcitriol) |
| تواريخ الأحداث: | Date Created: 20190608 Date Completed: 20200420 Latest Revision: 20200420 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.clim.2019.06.001 |
| PMID: | 31173888 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1521-7035 |
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| DOI: | 10.1016/j.clim.2019.06.001 |