دورية أكاديمية
أعرض في EDS

Association of Vitamin D Levels With Kidney Volume in Autosomal Dominant Polycystic Kidney Disease (ADPKD).

التفاصيل البيبلوغرافية
العنوان: Association of Vitamin D Levels With Kidney Volume in Autosomal Dominant Polycystic Kidney Disease (ADPKD).
المؤلفون: Vendramini LC; Nephrology Division, Universidade Federal de São Paulo, São Paulo, Brazil., Dalboni MA; Nephrology Division, Universidade Federal de São Paulo, São Paulo, Brazil., de Carvalho JTG Jr; Nephrology Division, Universidade Federal de São Paulo, São Paulo, Brazil., Batista MC; Nephrology Division, Universidade Federal de São Paulo, São Paulo, Brazil., Nishiura JL; Nephrology Division, Universidade Federal de São Paulo, São Paulo, Brazil., Heilberg IP; Nephrology Division, Universidade Federal de São Paulo, São Paulo, Brazil.
المصدر: Frontiers in medicine [Front Med (Lausanne)] 2019 May 24; Vol. 6, pp. 112. Date of Electronic Publication: 2019 May 24 (Print Publication: 2019).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101648047 Publication Model: eCollection Cited Medium: Print ISSN: 2296-858X (Print) Linking ISSN: 2296858X NLM ISO Abbreviation: Front Med (Lausanne) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne, Switzerland : Frontiers Media S.A., [2014]-
مستخلص: Vitamin D possesses renoprotective effects beyond mineral metabolism, potentially reducing arterial blood pressure and inflammation and vitamin D enzymes (CYP24A1 and CYP27B1) as well as vitamin D receptor (VDR) contribute to its homeostasis. In the present study, we aimed to determine vitamin D association with kidney volume, blood pressure parameters and inflammatory markers in ADPKD. This cross-sectional study, conducted from August 2011 through May 2016, evaluated 25(OH)D, 1,25(OH)2D and other hormonal/biochemical serum and urinary parameters, inflammatory markers and monocyte expression of VDR, CYP24A1, CYP27B1 in 74 ADPKD patients. The height-adjusted total kidney volume (htTKV) was determined by MRI and blood pressure (BP) measured through 24-h ambulatory BP monitoring (ABPM).Vitamin D insufficiency was present in 62% of patients and CYP24A1 was overexpressed in this group, raising a hypothesis of 25(OH)D increased catabolism. Serum 25(OH)D levels and VDR expression were negatively correlated with htTKV as was VDR with IL-6, IL-10, CRP, and NFκB. A multiple linear regression analysis with htTKV as dependent variable, including hypertension, CRP, eGFR, age, time since diagnosis, VDR, and 25(OH)D adjusted for season of the year showed that only the first three parameters were independent predictors of the former. There has been no association of serum 25(OH)D and VDR expression with ABPM parameters. Present findings suggested that low levels of serum 25(OH)D and VDR expression are associated with a higher kidney volume in ADPKD patients, but do not represent independent risk factors for htTKV.
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فهرسة مساهمة: Keywords: VDR; hypertension; inflammatory markers; total kidney volume (TKV); vitamin D
تواريخ الأحداث: Date Created: 20190611 Latest Revision: 20200930
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC6542997
DOI: 10.3389/fmed.2019.00112
PMID: 31179282
قاعدة البيانات: MEDLINE
الوصف
تدمد:2296-858X
DOI:10.3389/fmed.2019.00112