دورية أكاديمية
The balance of power: innate lymphoid cells in tissue inflammation and repair.
العنوان: | The balance of power: innate lymphoid cells in tissue inflammation and repair. |
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المؤلفون: | Castellanos JG, Longman RS |
المصدر: | The Journal of clinical investigation [J Clin Invest] 2019 Jun 10; Vol. 129 (7), pp. 2640-2650. Date of Electronic Publication: 2019 Jun 10 (Print Publication: 2019). |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
اللغة: | English |
بيانات الدورية: | Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: eCollection Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 1999- : Ann Arbor, MI : American Society for Clinical Investigation Original Publication: New Haven [etc.] American Society for Clinical Investigation. |
مواضيع طبية MeSH: | Immunity, Innate*, Regeneration/*immunology , T-Lymphocytes, Helper-Inducer/*immunology, Animals ; Cytokines/immunology ; Humans ; Inflammation/immunology ; Inflammation/pathology ; T-Lymphocytes, Helper-Inducer/pathology ; Transcription Factors/immunology |
مستخلص: | Over the last ten years, immunologists have recognized the central importance of an emerging group of innate lymphoid cells (ILCs) in health and disease. Characterization of these cells has provided a molecular definition of ILCs and their tissue-specific functions. Although the lineage-defining transcription factors, cytokine production, and nomenclature parallel those of T helper cells, ILCs do not require adaptive immune programming. Both environmental and host-derived signals shape the function of these evolutionarily ancient cells, which provide pathogen protection and promote tissue restoration. As such, ILCs function as a double-edged sword, balancing the inflammatory and reparative responses that arise during injury and disease. This Review highlights our recent understanding of tissue-resident ILCs and the signals that regulate their contribution to inflammation and tissue repair in health and disease. |
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معلومات مُعتمدة: | R01 DK114252 United States DK NIDDK NIH HHS; R03 DK111852 United States DK NIDDK NIH HHS; T32 GM007739 United States GM NIGMS NIH HHS |
المشرفين على المادة: | 0 (Cytokines) 0 (Transcription Factors) |
تواريخ الأحداث: | Date Created: 20190611 Date Completed: 20200519 Latest Revision: 20200701 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC6597213 |
DOI: | 10.1172/JCI124617 |
PMID: | 31180335 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1558-8238 |
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DOI: | 10.1172/JCI124617 |