دورية أكاديمية
أعرض في EDS

Is there any association between Toxoplasma gondii infection and depression? A systematic review and meta-analysis.

التفاصيل البيبلوغرافية
العنوان: Is there any association between Toxoplasma gondii infection and depression? A systematic review and meta-analysis.
المؤلفون: Nayeri Chegeni T; Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran.; Department of Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.; Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran., Sharif M; Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran.; Department of Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran., Sarvi S; Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran.; Department of Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran., Moosazadeh M; Health Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran., Montazeri M; Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran.; Department of Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran., Aghayan SA; Laboratory of Zoology, Research Institute of Biology, Yerevan State University, Yerevan, Armenia., Balalami NJ; Department of Humanity and Social Science, Mazandaran University, Babolsar, Iran., Gholami S; Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran.; Department of Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran., Hosseininejad Z; Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran.; Department of Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran., Saberi R; Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran.; Department of Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran., Anvari D; Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran.; Department of Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran., Gohardehi S; Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran., Daryani A; Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran.; Department of Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
المصدر: PloS one [PLoS One] 2019 Jun 13; Vol. 14 (6), pp. e0218524. Date of Electronic Publication: 2019 Jun 13 (Print Publication: 2019).
نوع المنشور: Journal Article; Meta-Analysis; Systematic Review
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Antibodies, Protozoan/*metabolism , Depressive Disorder/*immunology , Toxoplasmosis/*immunology, Case-Control Studies ; Cross-Sectional Studies ; Depressive Disorder/etiology ; Female ; Humans ; Male ; Odds Ratio ; Toxoplasma/immunology ; Toxoplasmosis/complications
مستخلص: Background: Toxoplasma gondii (T. gondii) is an obligate intracellular opportunistic parasite that is the causative agent of toxoplasmosis. This parasite accounts for mental disorders; however, the relationship between T. gondii infection and depressive disorder is unclear. Regarding this, the present systematic review and meta-analysis was conducted to investigate the scientific evidence regarding the potential association between major depression disorder (MDD) and Toxoplasma infection.
Methods: For the purpose of the study, the articles related to the subject of interest were systematically searched in seven electronic databases. Special attention was given to the studies examining T. gondii seropositivity level in depressed patients and controls.
Results: The search process resulted in the identification of a total of 30 publications meeting the inclusion criteria and published up to April 2018 for the systematic review. Furthermore, 29 studies met the inclusion criteria to be entered into meta-analysis. Our meta-analysis involved the review of cross-sectional studies including 1657 depressed patients and 19565 individuals as controls and case-control studies entailing 1311 depressed cases and 6015 controls without depression. 1582 depressed people participated in cross-sectional studies whose results were reported as odds ratio (OR). In addition, the total number of participants was 15068 in this type of studies. Statistical analysis indicated that the pooled OR of the risk of anti-T. gondii IgG antibody in depressed individuals in case-control and cross-sectional studies was 1.15 (95% confidence interval (CI): 0.95-1.39).
Conclusions: As the findings of the reviewed articles indicated, toxoplasmosis is not a risk factor for MDD. However, it is necessary to perform further research to clarify the detailed association between T. gondii and dysthymia or mild and moderate depression. Furthermore, it is recommended to better investigate the effect of antibody titers on the relationship between depression and T. gondii infection.
Competing Interests: The authors have declared that no competing interests exist.
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المشرفين على المادة: 0 (Antibodies, Protozoan)
تواريخ الأحداث: Date Created: 20190614 Date Completed: 20200214 Latest Revision: 20231012
رمز التحديث: 20240513
مُعرف محوري في PubMed: PMC6564815
DOI: 10.1371/journal.pone.0218524
PMID: 31194852
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0218524