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Cyclocarioside O-Q, three novel seco -dammarane triterpenoid glycosides from the leaves of Cyclocarya paliurus .

التفاصيل البيبلوغرافية
العنوان: Cyclocarioside O-Q, three novel seco -dammarane triterpenoid glycosides from the leaves of Cyclocarya paliurus .
المؤلفون: Xuan TY; Department of Pharmacy, Affiliated HaiKou Hospital Xiangya School of Medicine, Central South University, Haikou, PR China.; Department of Pharmacochemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, PR China., Tan J; Department of Pharmacochemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, PR China., Sun HH; Department of Pharmacochemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, PR China., Yang C; Department of Pharmacochemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, PR China., Lv WY; Department of Pharmacochemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, PR China., Zhang JH; Department of Pharmacochemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, PR China., Zhang KQ; Department of English Language and literature, School of Foreign Language, Central South University, Changsha, PR China., Nie ZQ; Division of Clinical Medicine, Xiangya School of Medicine, Central South University, Changsha, PR China., Ye ZJ; Department of Pharmacy, Affiliated HaiKou Hospital Xiangya School of Medicine, Central South University, Haikou, PR China., He XA; Department of Pharmacy, Affiliated HaiKou Hospital Xiangya School of Medicine, Central South University, Haikou, PR China., Zhu GZ; Department of Pharmacy, Affiliated HaiKou Hospital Xiangya School of Medicine, Central South University, Haikou, PR China., Xu KP; Department of Pharmacochemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, PR China.
المصدر: Natural product research [Nat Prod Res] 2021 Jan; Vol. 35 (1), pp. 167-173. Date of Electronic Publication: 2019 Jun 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003-
مواضيع طبية MeSH: Antineoplastic Agents, Phytogenic/*pharmacology , Juglandaceae/*chemistry , Triterpenes/*chemistry , Triterpenes/*pharmacology, Antineoplastic Agents, Phytogenic/chemistry ; Cell Line, Tumor ; Drug Screening Assays, Antitumor ; Glycosides/chemistry ; HCT116 Cells ; Hep G2 Cells ; Humans ; Magnetic Resonance Spectroscopy ; Molecular Structure ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/pathology ; Plant Leaves/chemistry ; Dammaranes
مستخلص: Three previously undescribed seco -dammarane triterpenoid glycosides O-Q ( 1-3 ) along with two known compounds ( 4 and 5 ) were isolated and characterized from the leaves of Cyclocarya paliurus . Their structures were determined by comprehensive analysis of 1 D, 2 D NMR and HRESIMS data. Compounds 1-5 were evaluated for their inhibitory effects against human pancreatic tumor (ASPC-1), human gastric carcinoma (SNU5), liver hepatocellular carcinoma (HEPG-2) and human colon tumor (HCT116) cell lines. Among them cyclocarioside P ( 2 ) showed somewhat inhibitory activity towards those tumor cells.
فهرسة مساهمة: Keywords: Cyclocarya paliurus; Cytotoxic activities; Seco-dammarane triterpenoid glycosides
المشرفين على المادة: 0 (Antineoplastic Agents, Phytogenic)
0 (Glycosides)
0 (Triterpenes)
تواريخ الأحداث: Date Created: 20190615 Date Completed: 20210224 Latest Revision: 20231213
رمز التحديث: 20231215
DOI: 10.1080/14786419.2019.1616722
PMID: 31198051
قاعدة البيانات: MEDLINE
الوصف
تدمد:1478-6427
DOI:10.1080/14786419.2019.1616722