دورية أكاديمية
Cyclocarioside O-Q, three novel seco -dammarane triterpenoid glycosides from the leaves of Cyclocarya paliurus .
العنوان: | Cyclocarioside O-Q, three novel seco -dammarane triterpenoid glycosides from the leaves of Cyclocarya paliurus . |
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المؤلفون: | Xuan TY; Department of Pharmacy, Affiliated HaiKou Hospital Xiangya School of Medicine, Central South University, Haikou, PR China.; Department of Pharmacochemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, PR China., Tan J; Department of Pharmacochemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, PR China., Sun HH; Department of Pharmacochemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, PR China., Yang C; Department of Pharmacochemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, PR China., Lv WY; Department of Pharmacochemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, PR China., Zhang JH; Department of Pharmacochemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, PR China., Zhang KQ; Department of English Language and literature, School of Foreign Language, Central South University, Changsha, PR China., Nie ZQ; Division of Clinical Medicine, Xiangya School of Medicine, Central South University, Changsha, PR China., Ye ZJ; Department of Pharmacy, Affiliated HaiKou Hospital Xiangya School of Medicine, Central South University, Haikou, PR China., He XA; Department of Pharmacy, Affiliated HaiKou Hospital Xiangya School of Medicine, Central South University, Haikou, PR China., Zhu GZ; Department of Pharmacy, Affiliated HaiKou Hospital Xiangya School of Medicine, Central South University, Haikou, PR China., Xu KP; Department of Pharmacochemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, PR China. |
المصدر: | Natural product research [Nat Prod Res] 2021 Jan; Vol. 35 (1), pp. 167-173. Date of Electronic Publication: 2019 Jun 14. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003- |
مواضيع طبية MeSH: | Antineoplastic Agents, Phytogenic/*pharmacology , Juglandaceae/*chemistry , Triterpenes/*chemistry , Triterpenes/*pharmacology, Antineoplastic Agents, Phytogenic/chemistry ; Cell Line, Tumor ; Drug Screening Assays, Antitumor ; Glycosides/chemistry ; HCT116 Cells ; Hep G2 Cells ; Humans ; Magnetic Resonance Spectroscopy ; Molecular Structure ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/pathology ; Plant Leaves/chemistry ; Dammaranes |
مستخلص: | Three previously undescribed seco -dammarane triterpenoid glycosides O-Q ( 1-3 ) along with two known compounds ( 4 and 5 ) were isolated and characterized from the leaves of Cyclocarya paliurus . Their structures were determined by comprehensive analysis of 1 D, 2 D NMR and HRESIMS data. Compounds 1-5 were evaluated for their inhibitory effects against human pancreatic tumor (ASPC-1), human gastric carcinoma (SNU5), liver hepatocellular carcinoma (HEPG-2) and human colon tumor (HCT116) cell lines. Among them cyclocarioside P ( 2 ) showed somewhat inhibitory activity towards those tumor cells. |
فهرسة مساهمة: | Keywords: Cyclocarya paliurus; Cytotoxic activities; Seco-dammarane triterpenoid glycosides |
المشرفين على المادة: | 0 (Antineoplastic Agents, Phytogenic) 0 (Glycosides) 0 (Triterpenes) |
تواريخ الأحداث: | Date Created: 20190615 Date Completed: 20210224 Latest Revision: 20231213 |
رمز التحديث: | 20231215 |
DOI: | 10.1080/14786419.2019.1616722 |
PMID: | 31198051 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1478-6427 |
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DOI: | 10.1080/14786419.2019.1616722 |