دورية أكاديمية

USPIO-enhanced MRI of pelvic lymph nodes at 7-T: preliminary experience.

التفاصيل البيبلوغرافية
العنوان: USPIO-enhanced MRI of pelvic lymph nodes at 7-T: preliminary experience.
المؤلفون: Philips BWJ; Department of Radiology and Nuclear Medicine (766), Radboud University Medical Center, P.O. Box 9101, Nijmegen, The Netherlands. bart.philips@radboudumc.nl., Stijns RCH; Department of Radiology and Nuclear Medicine (766), Radboud University Medical Center, P.O. Box 9101, Nijmegen, The Netherlands., Rietsch SHG; Erwin L Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, 45141, Essen, Germany.; High-Field and Hybrid MR Imaging, University Hospital Essen, 45147, Essen, Germany., Brunheim S; Erwin L Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, 45141, Essen, Germany.; High-Field and Hybrid MR Imaging, University Hospital Essen, 45147, Essen, Germany., Barentsz JO; Department of Radiology and Nuclear Medicine (766), Radboud University Medical Center, P.O. Box 9101, Nijmegen, The Netherlands., Fortuin AS; Department of Radiology and Nuclear Medicine (766), Radboud University Medical Center, P.O. Box 9101, Nijmegen, The Netherlands.; Department of Radiology, Ziekenhuis Gelderse Vallei, Ede, The Netherlands., Quick HH; Erwin L Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, 45141, Essen, Germany.; High-Field and Hybrid MR Imaging, University Hospital Essen, 45147, Essen, Germany., Orzada S; Erwin L Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, 45141, Essen, Germany.; High-Field and Hybrid MR Imaging, University Hospital Essen, 45147, Essen, Germany., Maas MC; Department of Radiology and Nuclear Medicine (766), Radboud University Medical Center, P.O. Box 9101, Nijmegen, The Netherlands., Scheenen TWJ; Department of Radiology and Nuclear Medicine (766), Radboud University Medical Center, P.O. Box 9101, Nijmegen, The Netherlands.; Erwin L Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, 45141, Essen, Germany.
المصدر: European radiology [Eur Radiol] 2019 Dec; Vol. 29 (12), pp. 6529-6538. Date of Electronic Publication: 2019 Jun 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer International Country of Publication: Germany NLM ID: 9114774 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1084 (Electronic) Linking ISSN: 09387994 NLM ISO Abbreviation: Eur Radiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin : Springer International, c1991-
مواضيع طبية MeSH: Contrast Media* , Dextrans* , Magnetite Nanoparticles*, Image Enhancement/*methods , Lymph Nodes/*diagnostic imaging , Lymphatic Metastasis/*diagnostic imaging , Magnetic Resonance Imaging/*methods, Aged ; Feasibility Studies ; Female ; Humans ; Lymph Nodes/pathology ; Lymphatic Metastasis/pathology ; Male ; Middle Aged ; Pelvis/pathology ; Reproducibility of Results
مستخلص: Purpose: To evaluate the technical feasibility of high-resolution USPIO-enhanced magnetic resonance imaging of pelvic lymph nodes (LNs) at ultrahigh magnetic field strength.
Materials and Methods: The ethics review board approved this study and written informed consent was obtained from all patients. Three patients with rectal cancer and three selected patients with (recurrent) prostate cancer were examined at 7-T 24-36 h after intravenous ferumoxtran-10 administration; rectal cancer patients also received a 3-T MRI. Pelvic LN imaging was performed using the TIAMO technique in combination with water-selective multi-GRE imaging and lipid-selective GRE imaging with a spatial resolution of 0.66 × 0.66 × 0.66mm 3 . T 2 * -weighted images of the water-selective imaging were computed from the multi-GRE images at TE = 0, 8, and 14 ms and used for the assessment of USPIO uptake.
Results: High-resolution 7-T MR gradient-echo imaging was obtained robustly in all patients without suffering from RF-related signal voids. USPIO signal decay in LNs was visualized using computed TE imaging at TE = 8 ms and an R 2 * map derived from water-selective imaging. Anatomically, LNs were identified on a combined reading of computed TE = 0 ms images from water-selective scans and images from lipid-selective scans. A range of 3-48 LNs without USPIO signal decay was found per patient. These LNs showed high signal intensity on computed TE = 8 and 14 ms imaging and low R 2 * (corresponding to high T 2 * ) values on the R 2 * map.
Conclusion: USPIO-enhanced MRI of the pelvis at 7-T is technically feasible and offers opportunities for detecting USPIO uptake in normal-sized LNs, due to its high intrinsic signal-to-noise ratio and spatial resolution.
Key Points: • USPIO-enhanced MRI at 7-T can indicate USPIO uptake in lymph nodes based on computed TE images. • Our method promises a high spatial resolution for pelvic lymph node imaging.
References: Med Phys. 2015 Aug;42(8):4542-52. (PMID: 26233183)
Eur Urol. 2016 Oct;70(4):553-557. (PMID: 26810345)
Eur Radiol. 2010 Feb;20(2):275-85. (PMID: 19705124)
Invest Radiol. 2009 Jul;44(7):375-83. (PMID: 19448552)
Eur J Radiol. 2011 Nov;80(2):582-9. (PMID: 20047813)
Lancet Oncol. 2008 Sep;9(9):850-6. (PMID: 18708295)
Med Phys. 2018 Jul;45(7):2978-2990. (PMID: 29679498)
Magn Reson Med. 2012 Apr;67(4):1033-41. (PMID: 21858867)
Eur Urol. 2009 Apr;55(4):761-9. (PMID: 19144456)
Eur J Cancer. 2013 Feb;49(3):616-24. (PMID: 23084842)
Contrast Media Mol Imaging. 2016 Nov;11(6):544-549. (PMID: 27976506)
J Clin Oncol. 2005 Apr 20;23(12):2813-21. (PMID: 15837995)
Magn Reson Med. 2010 Aug;64(2):327-33. (PMID: 20574991)
Radiology. 1998 Jun;207(3):799-808. (PMID: 9609907)
N Engl J Med. 2003 Jun 19;348(25):2491-9. (PMID: 12815134)
Acad Radiol. 2013 Dec;20(12):1604-9. (PMID: 24200489)
Eur Radiol. 2012 Jun;22(6):1186-94. (PMID: 22270141)
Magn Reson Med. 2017 Sep;78(3):1020-1028. (PMID: 27714842)
Radiology. 2010 Jan;254(1):31-46. (PMID: 20032141)
Neuroimage. 2013 Nov 1;81:335-346. (PMID: 23684865)
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2018 Jan;10(1):. (PMID: 28382713)
J Magn Reson Imaging. 1999 Sep;10(3):468-73. (PMID: 10508310)
Magn Reson Med. 2016 Feb;75(2):801-9. (PMID: 25820458)
J Urol. 2008 Mar;179(3):923-8; discussion 928-9. (PMID: 18207170)
Eur Urol. 2013 Dec;64(6):953-60. (PMID: 23916692)
Contrast Media Mol Imaging. 2012 May-Jun;7(3):346-55. (PMID: 22539405)
Magn Reson Med. 2018 May;79(5):2652-2664. (PMID: 28994132)
Radiology. 2003 Sep;228(3):777-88. (PMID: 12954896)
IEEE Trans Biomed Eng. 2014 May;61(5):1364-79. (PMID: 24686229)
Radiology. 2017 Sep;284(3):616-629. (PMID: 28825888)
Radiology. 2006 May;239(2):481-7. (PMID: 16641354)
AJR Am J Roentgenol. 1999 May;172(5):1347-51. (PMID: 10227514)
معلومات مُعتمدة: KUN 2014-6624 KWF Kankerbestrijding (NL)
فهرسة مساهمة: Keywords: Ferumoxtran-10; Lymph nodes; Magnetic resonance imaging; Metastasis; Pelvis
المشرفين على المادة: 0 (Contrast Media)
0 (Dextrans)
0 (Magnetite Nanoparticles)
0 (ferumoxtran-10)
تواريخ الأحداث: Date Created: 20190616 Date Completed: 20200213 Latest Revision: 20210109
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6828641
DOI: 10.1007/s00330-019-06277-7
PMID: 31201525
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-1084
DOI:10.1007/s00330-019-06277-7