دورية أكاديمية
The Ways of Tails: the GET Pathway and more.
العنوان: | The Ways of Tails: the GET Pathway and more. |
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المؤلفون: | Borgese N; Institute of Neuroscience and BIOMETRA Department, Consiglio Nazionale delle Ricerche and Università degli Studi di Milano, via Vanvitelli 32, 20129, Milan, Italy. n.borgese@in.cnr.it., Coy-Vergara J; Department of Molecular Biology, University of Göttingen Medical Centre, Humboldtallee 23, 37073, Göttingen, Germany., Colombo SF; Institute of Neuroscience and BIOMETRA Department, Consiglio Nazionale delle Ricerche and Università degli Studi di Milano, via Vanvitelli 32, 20129, Milan, Italy., Schwappach B; Department of Molecular Biology, University of Göttingen Medical Centre, Humboldtallee 23, 37073, Göttingen, Germany. Blanche.schwappach@med.uni-goettingen.de. |
المصدر: | The protein journal [Protein J] 2019 Jun; Vol. 38 (3), pp. 289-305. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Springer Country of Publication: Netherlands NLM ID: 101212092 Publication Model: Print Cited Medium: Internet ISSN: 1875-8355 (Electronic) Linking ISSN: 15723887 NLM ISO Abbreviation: Protein J Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2005- : Dordrecht : Springer Original Publication: Dordrecht, The Netherlands ; New York : Kluwer Academic/Plenum, c2004- |
مواضيع طبية MeSH: | Membrane Proteins*/chemistry , Membrane Proteins*/metabolism , Signal Recognition Particle*/chemistry , Signal Recognition Particle*/metabolism, Cell Membrane/*metabolism , Saccharomyces cerevisiae Proteins/*metabolism, Animals ; Humans ; Mice ; Protein Processing, Post-Translational ; Protein Transport ; Saccharomyces cerevisiae/metabolism |
مستخلص: | Due to their topology tail-anchored (TA) proteins must target to the membrane independently of the co-translational route defined by the signal sequence recognition particle (SRP), its receptor and the translocon Sec61. More than a decade of work has extensively characterized a highly conserved pathway, the yeast GET or mammalian TRC40 pathway, which is capable of countering the biogenetic challenge posed by the C-terminal TA anchor. In this review we briefly summarize current models of this targeting route and focus on emerging aspects such as the intricate interplay with the proteostatic network of cells and with other targeting pathways. Importantly, we consider the lessons provided by the in vivo analysis of the pathway in different model organisms and by the consideration of its full client spectrum in more recent studies. This analysis of the state of the field highlights directions in which the current models may be experimentally probed and conceptually extended. |
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معلومات مُعتمدة: | REA Grant 607072 United Kingdom MCCC_ Marie Curie |
فهرسة مساهمة: | Keywords: Endoplasmic reticulum; Membrane targeting; Mitochondrial outer membrane; Peroxisomes; TRC40; Tail-anchored protein |
المشرفين على المادة: | 0 (Membrane Proteins) 0 (Saccharomyces cerevisiae Proteins) 0 (Signal Recognition Particle) |
تواريخ الأحداث: | Date Created: 20190617 Date Completed: 20200129 Latest Revision: 20200309 |
رمز التحديث: | 20221213 |
DOI: | 10.1007/s10930-019-09845-4 |
PMID: | 31203484 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1875-8355 |
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DOI: | 10.1007/s10930-019-09845-4 |