دورية أكاديمية
In vitro study on α-amylase and α-glucosidase inhibitory activities of a new stigmastane-type steroid saponin from the leaves of Vernonia amygdalina .
| العنوان: | In vitro study on α-amylase and α-glucosidase inhibitory activities of a new stigmastane-type steroid saponin from the leaves of Vernonia amygdalina . |
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| المؤلفون: | Anh HLT; Mientrung Institute for Scientific Research Vietnam Academy of Science and Technology, Hue city, Vietnam.; Graduate University of Science and Technology Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam., Vinh LB; College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea.; Institute of Marine Biochemistry Vietnam Academy of Science and Technology, Ha Noi, Vietnam., Lien LT; Mientrung Institute for Scientific Research Vietnam Academy of Science and Technology, Hue city, Vietnam.; Graduate University of Science and Technology Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam., Cuong PV; Mientrung Institute for Scientific Research Vietnam Academy of Science and Technology, Hue city, Vietnam., Arai M; Research Center for Drug Discovery, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan., Ha TP; Mientrung Institute for Scientific Research Vietnam Academy of Science and Technology, Hue city, Vietnam., Lin HN; Mientrung Institute for Scientific Research Vietnam Academy of Science and Technology, Hue city, Vietnam., Dat TTH; Mientrung Institute for Scientific Research Vietnam Academy of Science and Technology, Hue city, Vietnam., Cuong LCV; Mientrung Institute for Scientific Research Vietnam Academy of Science and Technology, Hue city, Vietnam., Kim YH; College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea. |
| المصدر: | Natural product research [Nat Prod Res] 2021 Mar; Vol. 35 (5), pp. 873-879. Date of Electronic Publication: 2019 Jun 17. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003- |
| مواضيع طبية MeSH: | Glycoside Hydrolase Inhibitors/*pharmacology , Plant Leaves/*chemistry , Saponins/*pharmacology , Steroids/*pharmacology , Vernonia/*chemistry , alpha-Amylases/*antagonists & inhibitors , alpha-Glucosidases/*metabolism, Glycoside Hydrolase Inhibitors/chemistry ; Magnetic Resonance Spectroscopy ; Plant Extracts/chemistry ; Saponins/chemistry ; Steroids/chemistry ; alpha-Amylases/metabolism |
| مستخلص: | Using various chromatographic separations, four compounds, including one new steroid saponin named vernoamyoside E ( 1 ), were isolated from the leaves of the Vietnamese medicinal plant Vernonia amygdalina Delile (Asteraceae). Their structures were established by spectroscopic methods such as 1D- and 2D-NMR, HR-ESI-MS, and HPLC analysis. The inhibitory activities against α-glucosidase and α-amylase of the isolated compounds from V. amygdalina were reported for the first time. The results indicated that compound 1 significantly inhibited both against α-amylase and α-glucosidase activity. |
| فهرسة مساهمة: | Keywords: Asteraceae; Vernonia amygdalina; vernomyoside E; α-amylase inhibitory; α-glucosidase inhibitory |
| المشرفين على المادة: | 0 (Glycoside Hydrolase Inhibitors) 0 (Plant Extracts) 0 (Saponins) 0 (Steroids) EC 3.2.1.1 (alpha-Amylases) EC 3.2.1.20 (alpha-Glucosidases) |
| تواريخ الأحداث: | Date Created: 20190618 Date Completed: 20210426 Latest Revision: 20210426 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1080/14786419.2019.1607853 |
| PMID: | 31204853 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1478-6427 |
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| DOI: | 10.1080/14786419.2019.1607853 |