دورية أكاديمية
Metabolic Profiling of the Diabetic Heart: Toward a Richer Picture.
العنوان: | Metabolic Profiling of the Diabetic Heart: Toward a Richer Picture. |
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المؤلفون: | Sowton AP; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom., Griffin JL; Department of Biochemistry and Systems Biology Centre, University of Cambridge, Cambridge, United Kingdom., Murray AJ; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom. |
المصدر: | Frontiers in physiology [Front Physiol] 2019 May 31; Vol. 10, pp. 639. Date of Electronic Publication: 2019 May 31 (Print Publication: 2019). |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101549006 Publication Model: eCollection Cited Medium: Print ISSN: 1664-042X (Print) Linking ISSN: 1664042X NLM ISO Abbreviation: Front Physiol Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Research Foundation |
مستخلص: | The increasing global prevalence of diabetes has been accompanied by a rise in diabetes-related conditions. This includes diabetic cardiomyopathy (DbCM), a progressive form of heart disease that occurs with both insulin-dependent (type-1) and insulin-independent (type-2) diabetes and arises in the absence of hypertension or coronary artery disease. Over time, DbCM can develop into overt heart failure. Like other forms of cardiomyopathy, DbCM is accompanied by alterations in metabolism which could lead to further progression of the pathology, with metabolic derangement postulated to precede functional changes in the diabetic heart. Moreover in the case of type-2 diabetes, underlying insulin resistance is likely to prevent the canonical substrate switch of the failing heart away from fatty acid oxidation toward increased use of glycolysis. Analytical chemistry techniques, collectively known as metabolomics, are useful tools for investigating the condition. In this article, we provide a comprehensive review of those studies that have employed metabolomic techniques, namely chromatography, mass spectrometry and nuclear magnetic resonance spectroscopy, to profile metabolic remodeling in the diabetic heart of human patients and animal models. These studies collectively demonstrate that glycolysis and glucose oxidation are suppressed in the diabetic myocardium and highlight a complex picture regarding lipid metabolism. The diabetic heart typically shows an increased reliance on fatty acid oxidation, yet triacylglycerols and other lipids accumulate in the diabetic myocardium indicating probable lipotoxicity. The application of lipidomic techniques to the diabetic heart has identified specific lipid species that become enriched and which may in turn act as plasma-borne biomarkers for the condition. Metabolomics is proving to be a powerful approach, allowing a much richer analysis of the metabolic alterations that occur in the diabetic heart. Careful physiological interpretation of metabolomic results will now be key in order to establish which aspects of the metabolic derangement are causal to the progression of DbCM and might form the basis for novel therapeutic intervention. |
References: | J Am Coll Cardiol. 2008 Nov 25;52(22):1793-9. (PMID: 19022158) J Biol Chem. 1991 Dec 5;266(34):22932-8. (PMID: 1744086) World J Diabetes. 2013 Oct 15;4(5):177-89. (PMID: 24147202) Cardiovasc Res. 2015 May 1;106(2):249-60. (PMID: 25750189) Metabolomics. 2016 May;12(5):. (PMID: 28775675) Diabetes. 2004 Jul;53(7):1655-63. (PMID: 15220187) Magn Reson Med. 2008 May;59(5):1005-13. (PMID: 18429038) J Am Coll Cardiol. 2009 Oct 13;54(16):1524-32. (PMID: 19815124) Cardiovasc Ther. 2012 Dec;30(6):333-41. (PMID: 21884010) Diabetes. 2016 May;65(5):1190-5. (PMID: 26861783) Cardiovasc Res. 2011 Jan 1;89(1):148-56. (PMID: 20729341) Circulation. 2016 Feb 23;133(8):706-16. (PMID: 26819374) Nutr Metab (Lond). 2016 Oct 4;13:65. (PMID: 27708685) Am J Physiol Endocrinol Metab. 2005 Nov;289(5):E935-9. (PMID: 15972271) Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):12051-6. (PMID: 18689683) Cardiovasc Res. 2017 Feb 08;113(4):422-430. (PMID: 28177068) J Clin Endocrinol Metab. 2006 Nov;91(11):4689-95. (PMID: 16926257) J Mol Cell Cardiol. 1970 Sep;1(3):209-20. (PMID: 5519937) Am J Physiol Heart Circ Physiol. 2005 May;288(5):H2102-10. (PMID: 15615844) Diabetes Metab Res Rev. 2014 Mar;30 Suppl 1:4-12. (PMID: 24353270) BMC Cardiovasc Disord. 2015 May 13;15:42. (PMID: 25967112) Free Radic Biol Med. 1995 Feb;18(2):337-41. (PMID: 7744318) Diabetes. 2013 Jan;62(1):1-8. (PMID: 23258903) Endocrinology. 1972 May;90(5):1320-30. (PMID: 5012744) Cardiovasc Diabetol. 2009 Jul 22;8:39. (PMID: 19624828) Obesity (Silver Spring). 2007 Apr;15(4):798-808. (PMID: 17426312) Circulation. 2010 Dec 14;122(24):2538-44. (PMID: 21126971) Cell Physiol Biochem. 2018;48(3):934-946. (PMID: 30036879) Cardiovasc Res. 2017 Aug 01;113(10):1148-1160. (PMID: 28549111) Lancet. 1963 Apr 13;1(7285):785-9. (PMID: 13990765) Proc Natl Acad Sci U S A. 1977 Jun;74(6):2485-9. (PMID: 142253) N Engl J Med. 2007 Mar 15;356(11):1140-51. (PMID: 17360992) J Clin Endocrinol Metab. 2016 Feb;101(2):504-12. (PMID: 26652763) Diabetes Care. 2003 Oct;26(10):2949-51. (PMID: 14514607) Diabet Med. 2005 Apr;22(4):359-70. (PMID: 15787657) Anal Chem. 2012 Jan 17;84(2):1117-25. (PMID: 22141424) Am J Physiol. 1990 Apr;258(4 Pt 1):E606-18. (PMID: 2333960) J Diabetes Complications. 2004 Nov-Dec;18(6):367-76. (PMID: 15531188) Science. 1966 Sep 2;153(3740):1127-8. (PMID: 5918576) Basic Res Cardiol. 2011 May;106(3):447-57. (PMID: 21318295) Arch Cardiovasc Dis. 2012 Apr;105(4):218-25. (PMID: 22633296) Circulation. 1997 Oct 7;96(7):2190-6. (PMID: 9337189) Am J Med. 1954 Apr;16(4):504-15. (PMID: 13148192) Top Magn Reson Imaging. 2016 Feb;25(1):31-7. (PMID: 26848559) Int J Cardiol. 2007 Jan 8;114(2):195-201. (PMID: 21882490) Circ Res. 2018 Feb 16;122(4):624-638. (PMID: 29449364) Methods Mol Biol. 2012;933:103-23. (PMID: 22893404) Biochemistry. 2005 Apr 5;44(13):5234-45. (PMID: 15794660) PLoS One. 2012;7(12):e50077. (PMID: 23226508) Curr Protoc Pharmacol. 2012 Sep;Chapter 5:Unit5.61. (PMID: 22948848) Cell. 1996 Feb 9;84(3):491-5. (PMID: 8608603) J Mol Cell Cardiol. 1999 Dec;31(12):2175-89. (PMID: 10640445) Int J Mol Sci. 2016 Dec 18;17(12):. (PMID: 27999359) J Physiol. 2014 Nov 1;592(21):4715-31. (PMID: 25172947) J Diabetes. 2018 May;10(5):350-352. (PMID: 29369529) Cardiovasc Res. 2010 Oct 1;88(1):40-50. (PMID: 20668004) J Clin Invest. 2009 Jan;119(1):80-90. (PMID: 19065048) Circulation. 2003 Jun 24;107(24):3040-6. (PMID: 12810608) Extrem Physiol Med. 2015 May 04;4:7. (PMID: 25949809) Diabetes. 2016 Jan;65(1):44-52. (PMID: 26438611) Eur Heart J. 1994 Nov;15(11):1528-32. (PMID: 7835369) J Cardiovasc Magn Reson. 2013 Nov 14;15:103. (PMID: 24228979) Eur Heart J. 2016 Dec 07;37(46):3461-3469. (PMID: 26392437) Basic Res Cardiol. 2011 Mar;106(2):307-15. (PMID: 21181177) FASEB J. 2009 Aug;23(8):2529-38. (PMID: 19329759) J Mol Cell Cardiol. 1993 Oct;25(10):1203-13. (PMID: 8263954) Diabetes. 2015 Aug;64(8):2735-43. (PMID: 25795215) Nucleic Acids Res. 2007 Jan;35(Database issue):D521-6. (PMID: 17202168) Diabetes Care. 2007 Jun;30(6):1520-6. (PMID: 17384336) Basic Res Cardiol. 1997 Aug;92(4):214-22. (PMID: 9342428) JACC Basic Transl Sci. 2018 Aug 28;3(4):485-498. (PMID: 30175272) Diabetologia. 2008 Feb;51(2):216-26. (PMID: 18087688) Cardiovasc Res. 2002 Jul;55(1):104-12. (PMID: 12062713) Cardiovasc Drugs Ther. 2008 Apr;22(2):91-5. (PMID: 18247112) Am J Physiol Heart Circ Physiol. 2017 Nov 1;313(5):H1054-H1062. (PMID: 28801525) J Lipid Res. 2010 Jan;51(1):74-80. (PMID: 19617631) Physiol Rev. 2005 Jul;85(3):1093-129. (PMID: 15987803) Am J Physiol. 1997 Jul;273(1 Pt 2):H52-8. (PMID: 9249474) Am J Physiol Endocrinol Metab. 2008 Sep;295(3):E714-8. (PMID: 18628354) Methods Enzymol. 2009;457:349-72. (PMID: 19426878) Anal Chem. 2015 Jul 7;87(13):6426-33. (PMID: 25803124) Curr Opin Immunol. 1994 Dec;6(6):900-6. (PMID: 7710714) Diabetes. 1997 May;46(5):887-94. (PMID: 9133560) Chem Soc Rev. 2011 Jan;40(1):387-426. (PMID: 20717559) J Am Coll Cardiol. 2006 Feb 7;47(3):598-604. (PMID: 16458143) Nat Rev Cardiol. 2011 Sep 20;8(11):630-43. (PMID: 21931361) Int J Cardiol. 2013 Aug 10;167(3):905-9. (PMID: 22494864) Biochemistry. 2007 May 29;46(21):6417-28. (PMID: 17487985) Diabetes. 2018 Jun;67(6):1057-1067. (PMID: 29610263) Int J Cardiovasc Imaging. 2013 Jun;29(5):1043-50. (PMID: 23269470) Front Physiol. 2018 Aug 02;9:1042. (PMID: 30131709) Lancet. 2016 Apr 9;387(10027):1513-1530. (PMID: 27061677) Diabetes. 1983 Sep;32(9):781-7. (PMID: 6414861) Dis Model Mech. 2009 Sep-Oct;2(9-10):454-66. (PMID: 19726805) J Exp Med. 1987 Jun 1;165(6):1639-54. (PMID: 3585250) J Clin Endocrinol Metab. 2008 Feb;93(2):497-503. (PMID: 18029455) Cardiovasc Res. 2015 Sep 1;107(4):453-65. (PMID: 26101264) Genomics. 1991 Dec;11(4):1054-62. (PMID: 1686014) Nature. 1994 Dec 1;372(6505):425-32. (PMID: 7984236) Curr Diabetes Rev. 2014 Mar;10(2):131-45. (PMID: 24809394) Free Radic Res. 2015;49(9):1140-6. (PMID: 25968951) Diabetol Metab Syndr. 2017 Jul 20;9:56. (PMID: 28736579) J Nucl Med. 2008 Aug;49(8):1320-7. (PMID: 18632819) Circulation. 2007 Sep 4;116(10):1170-5. (PMID: 17698735) Biochim Biophys Acta. 2008 Jun-Jul;1781(6-7):352-8. (PMID: 18522808) Circulation. 2012 Jun 12;125(23):2844-53. (PMID: 22586279) J Am Coll Cardiol. 2003 Jul 16;42(2):328-35. (PMID: 12875772) Magn Reson Med. 2003 Mar;49(3):417-23. (PMID: 12594743) Biochim Biophys Acta. 2014 Oct;1842(10):1525-37. (PMID: 25086219) Circulation. 2005 Mar 22;111(11):1448-54. (PMID: 15781756) J Clin Invest. 1999 Jan;103(1):27-37. (PMID: 9884331) Pharmacol Res. 2005 Oct;52(4):313-20. (PMID: 15979893) Diabetes. 1988 Sep;37(9):1163-7. (PMID: 3044882) NMR Biomed. 2011 Feb;24(2):201-208. (PMID: 20799252) Int J Obes Relat Metab Disord. 2000 Nov;24 Suppl 4:S28-32. (PMID: 11126236) Am J Physiol Heart Circ Physiol. 2004 Sep;287(3):H1225-31. (PMID: 15130883) Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1226-31. (PMID: 12552126) J Proteome Res. 2015 Jul 2;14(7):2849-62. (PMID: 25985803) Amino Acids. 2011 May;40(5):1271-96. (PMID: 21448658) Biochemistry. 2005 Dec 20;44(50):16684-94. (PMID: 16342958) Am J Physiol Heart Circ Physiol. 2009 Dec;297(6):H2096-108. (PMID: 19801494) Basic Res Cardiol. 1995 Sep-Oct;90(5):388-96. (PMID: 8585860) J Diabetes Res. 2013;2013:761314. (PMID: 23691518) Cardiovasc Res. 2010 Nov 1;88(2):229-40. (PMID: 20639213) Am J Physiol Endocrinol Metab. 2006 Mar;290(3):E448-55. (PMID: 16234271) Hepatology. 2017 Apr;65(4):1165-1180. (PMID: 27863448) Cardiovasc Diabetol. 2013 Sep 24;12:136. (PMID: 24063408) Diabetes Metab Syndr Obes. 2015 Apr 02;8:181-8. (PMID: 25897251) J Cardiovasc Magn Reson. 2015 Nov 06;17:95. (PMID: 26546347) Am J Physiol. 1999 Aug;277(2):E342-51. (PMID: 10444431) Circulation. 2016 Feb 23;133(8):698-705. (PMID: 26819376) Diabetes. 1994 Nov;43(11):1326-33. (PMID: 7926307) Diabetes. 2006 Feb;55(2):466-73. (PMID: 16443782) NMR Biomed. 2011 Oct;24(8):980-987. (PMID: 21387444) Biochem J. 1967 Aug;104(2):416-22. (PMID: 6048783) Circulation. 2009 Apr 21;119(15):2069-77. (PMID: 19349323) J Chromatogr Sci. 2013 Aug;51(7):704-15. (PMID: 23592825) JACC Basic Transl Sci. 2016 Oct;1(6):432-444. (PMID: 28497127) Circulation. 2004 May 11;109(18):2191-6. (PMID: 15123530) Am J Physiol Heart Circ Physiol. 2017 Feb 1;312(2):H305-H313. (PMID: 28011586) Can J Cardiol. 1997 Apr;13(4):373-9. (PMID: 9141969) Am J Clin Nutr. 2011 Apr;93(4):748-55. (PMID: 21270386) Cardiovasc Res. 2013 Mar 15;97(4):676-85. (PMID: 23257023) J Nucl Med. 2006 Apr;47(4):689-97. (PMID: 16595504) Lab Anim. 2011 Jul;45(3):131-40. (PMID: 21478271) |
معلومات مُعتمدة: | MC_PC_13030 United Kingdom MRC_ Medical Research Council; MC_UP_A090_1006 United Kingdom MRC_ Medical Research Council; MR/P011705/1 United Kingdom MRC_ Medical Research Council; MR/P01836X/1 United Kingdom MRC_ Medical Research Council |
فهرسة مساهمة: | Keywords: animal models; diabetic cardiomyopathy; heart failure; lipidomics; metabolomics; mitochondria |
تواريخ الأحداث: | Date Created: 20190620 Latest Revision: 20240717 |
رمز التحديث: | 20240717 |
مُعرف محوري في PubMed: | PMC6555155 |
DOI: | 10.3389/fphys.2019.00639 |
PMID: | 31214041 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1664-042X |
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DOI: | 10.3389/fphys.2019.00639 |