دورية أكاديمية
Metabolic Profiling of the Diabetic Heart: Toward a Richer Picture.
| العنوان: | Metabolic Profiling of the Diabetic Heart: Toward a Richer Picture. |
|---|---|
| المؤلفون: | Sowton AP; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom., Griffin JL; Department of Biochemistry and Systems Biology Centre, University of Cambridge, Cambridge, United Kingdom., Murray AJ; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom. |
| المصدر: | Frontiers in physiology [Front Physiol] 2019 May 31; Vol. 10, pp. 639. Date of Electronic Publication: 2019 May 31 (Print Publication: 2019). |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101549006 Publication Model: eCollection Cited Medium: Print ISSN: 1664-042X (Print) Linking ISSN: 1664042X NLM ISO Abbreviation: Front Physiol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Research Foundation |
| مستخلص: | The increasing global prevalence of diabetes has been accompanied by a rise in diabetes-related conditions. This includes diabetic cardiomyopathy (DbCM), a progressive form of heart disease that occurs with both insulin-dependent (type-1) and insulin-independent (type-2) diabetes and arises in the absence of hypertension or coronary artery disease. Over time, DbCM can develop into overt heart failure. Like other forms of cardiomyopathy, DbCM is accompanied by alterations in metabolism which could lead to further progression of the pathology, with metabolic derangement postulated to precede functional changes in the diabetic heart. Moreover in the case of type-2 diabetes, underlying insulin resistance is likely to prevent the canonical substrate switch of the failing heart away from fatty acid oxidation toward increased use of glycolysis. Analytical chemistry techniques, collectively known as metabolomics, are useful tools for investigating the condition. In this article, we provide a comprehensive review of those studies that have employed metabolomic techniques, namely chromatography, mass spectrometry and nuclear magnetic resonance spectroscopy, to profile metabolic remodeling in the diabetic heart of human patients and animal models. These studies collectively demonstrate that glycolysis and glucose oxidation are suppressed in the diabetic myocardium and highlight a complex picture regarding lipid metabolism. The diabetic heart typically shows an increased reliance on fatty acid oxidation, yet triacylglycerols and other lipids accumulate in the diabetic myocardium indicating probable lipotoxicity. The application of lipidomic techniques to the diabetic heart has identified specific lipid species that become enriched and which may in turn act as plasma-borne biomarkers for the condition. Metabolomics is proving to be a powerful approach, allowing a much richer analysis of the metabolic alterations that occur in the diabetic heart. Careful physiological interpretation of metabolomic results will now be key in order to establish which aspects of the metabolic derangement are causal to the progression of DbCM and might form the basis for novel therapeutic intervention. |
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| معلومات مُعتمدة: | MC_PC_13030 United Kingdom MRC_ Medical Research Council; MC_UP_A090_1006 United Kingdom MRC_ Medical Research Council; MR/P011705/1 United Kingdom MRC_ Medical Research Council; MR/P01836X/1 United Kingdom MRC_ Medical Research Council |
| فهرسة مساهمة: | Keywords: animal models; diabetic cardiomyopathy; heart failure; lipidomics; metabolomics; mitochondria |
| تواريخ الأحداث: | Date Created: 20190620 Latest Revision: 20240717 |
| رمز التحديث: | 20240717 |
| مُعرف محوري في PubMed: | PMC6555155 |
| DOI: | 10.3389/fphys.2019.00639 |
| PMID: | 31214041 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1664-042X |
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| DOI: | 10.3389/fphys.2019.00639 |