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Circadian glucocorticoid oscillations preserve a population of adult hippocampal neural stem cells in the aging brain.

التفاصيل البيبلوغرافية
العنوان: Circadian glucocorticoid oscillations preserve a population of adult hippocampal neural stem cells in the aging brain.
المؤلفون: Schouten M; Neuroscience Collaboration, Swammerdam Institute for Life Sciences, Faculty of Sciences, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, The Netherlands.; Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam Neuroscience, Amsterdam, The Netherlands., Bielefeld P; Neuroscience Collaboration, Swammerdam Institute for Life Sciences, Faculty of Sciences, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, The Netherlands., Garcia-Corzo L; Biomedicine Institute of Valencia (IBV), Consejo Superior de Investigaciones Científicas (CSIC), Valencia, Spain., Passchier EMJ; Neuroscience Collaboration, Swammerdam Institute for Life Sciences, Faculty of Sciences, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, The Netherlands., Gradari S; Cajal Institute, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain., Jungenitz T; Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe-University Frankfurt, Frankfurt am Main, Germany., Pons-Espinal M; Neurobiology of miRNA Lab, Neuroscience and Brain Technologies Department, Istituto Italiano di Tecnologia, Genoa, Italy., Gebara E; Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland., Martín-Suárez S; Achucarro Basque Center for Neuroscience, Leioa, Spain., Lucassen PJ; Neuroscience Collaboration, Swammerdam Institute for Life Sciences, Faculty of Sciences, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, The Netherlands., De Vries HE; Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam Neuroscience, Amsterdam, The Netherlands., Trejo JL; Cajal Institute, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain., Schwarzacher SW; Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe-University Frankfurt, Frankfurt am Main, Germany., De Pietri Tonelli D; Neurobiology of miRNA Lab, Neuroscience and Brain Technologies Department, Istituto Italiano di Tecnologia, Genoa, Italy., Toni N; Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland., Mira H; Biomedicine Institute of Valencia (IBV), Consejo Superior de Investigaciones Científicas (CSIC), Valencia, Spain., Encinas JM; Achucarro Basque Center for Neuroscience, Leioa, Spain.; Ikerbasque, The Basque Foundation for Science, Bilbao, Spain.; University of the Basque Country (UPV/EHU), Leioa, Spain., Fitzsimons CP; Neuroscience Collaboration, Swammerdam Institute for Life Sciences, Faculty of Sciences, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, The Netherlands. c.p.fitzsimons@uva.nl.
المصدر: Molecular psychiatry [Mol Psychiatry] 2020 Jul; Vol. 25 (7), pp. 1382-1405. Date of Electronic Publication: 2019 Jun 20.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
أسماء مطبوعة: Publication: 2000- : Houndmills, Basingstoke, UK : Nature Publishing Group Specialist Journals
Original Publication: Houndmills, Hampshire, UK ; New York, NY : Stockton Press, c1996-
مواضيع طبية MeSH: Circadian Rhythm*, Aging/*metabolism , Brain/*metabolism , Glucocorticoids/*metabolism , Hippocampus/*cytology , Neural Stem Cells/*metabolism, Animals ; Brain/cytology ; Cell Proliferation ; Male ; Mice ; Neurogenesis ; Receptors, Glucocorticoid/metabolism
مستخلص: A decrease in adult hippocampal neurogenesis has been linked to age-related cognitive impairment. However, the mechanisms involved in this age-related reduction remain elusive. Glucocorticoid hormones (GC) are important regulators of neural stem/precursor cells (NSPC) proliferation. GC are released from the adrenal glands in ultradian secretory pulses that generate characteristic circadian oscillations. Here, we investigated the hypothesis that GC oscillations prevent NSPC activation and preserve a quiescent NSPC pool in the aging hippocampus. We found that hippocampal NSPC populations lacking expression of the glucocorticoid receptor (GR) decayed exponentially with age, while GR-positive populations decayed linearly and predominated in the hippocampus from middle age onwards. Importantly, GC oscillations controlled NSPC activation and GR knockdown reactivated NSPC proliferation in aged mice. When modeled in primary hippocampal NSPC cultures, GC oscillations control cell cycle progression and induce specific genome-wide DNA methylation profiles. GC oscillations induced lasting changes in the methylation state of a group of gene promoters associated with cell cycle regulation and the canonical Wnt signaling pathway. Finally, in a mouse model of accelerated aging, we show that disruption of GC oscillations induces lasting changes in dendritic complexity, spine numbers and morphology of newborn granule neurons. Together, these results indicate that GC oscillations preserve a population of GR-expressing NSPC during aging, preventing their activation possibly by epigenetic programming through methylation of specific gene promoters. Our observations suggest a novel mechanism mediated by GC that controls NSPC proliferation and preserves a dormant NSPC pool, possibly contributing to a neuroplasticity reserve in the aging brain.
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المشرفين على المادة: 0 (Glucocorticoids)
0 (Receptors, Glucocorticoid)
تواريخ الأحداث: Date Created: 20190622 Date Completed: 20210317 Latest Revision: 20231111
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7303016
DOI: 10.1038/s41380-019-0440-2
PMID: 31222184
قاعدة البيانات: MEDLINE
الوصف
تدمد:1476-5578
DOI:10.1038/s41380-019-0440-2