دورية أكاديمية
An Oxygen-Dependent Interaction between FBXL5 and the CIA-Targeting Complex Regulates Iron Homeostasis.
| العنوان: | An Oxygen-Dependent Interaction between FBXL5 and the CIA-Targeting Complex Regulates Iron Homeostasis. |
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| المؤلفون: | Mayank AK; Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Pandey V; Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Vashisht AA; Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Barshop WD; Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Rayatpisheh S; Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Sharma T; Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Haque T; Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Powers DN; Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Wohlschlegel JA; Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. Electronic address: jwohl@ucla.edu. |
| المصدر: | Molecular cell [Mol Cell] 2019 Jul 25; Vol. 75 (2), pp. 382-393.e5. Date of Electronic Publication: 2019 Jun 19. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Cambridge Ma : Cell Press Original Publication: Cambridge, Mass. : Cell Press, c1997- |
| مواضيع طبية MeSH: | Cell Cycle Proteins/*genetics , F-Box Proteins/*genetics , Molecular Chaperones/*genetics , Multiprotein Complexes/*genetics , Ubiquitin-Protein Ligase Complexes/*genetics, Cell Cycle Proteins/chemistry ; F-Box Proteins/chemistry ; HeLa Cells ; Homeostasis ; Humans ; Iron/metabolism ; Iron-Regulatory Proteins/genetics ; Iron-Sulfur Proteins/chemistry ; Iron-Sulfur Proteins/genetics ; Molecular Chaperones/chemistry ; Multiprotein Complexes/chemistry ; Oxygen/metabolism ; Proteolysis ; Transcription Factors/genetics ; Ubiquitin-Protein Ligase Complexes/chemistry |
| مستخلص: | The iron-sensing protein FBXL5 is the substrate adaptor for a SKP1-CUL1-RBX1 E3 ubiquitin ligase complex that regulates the degradation of iron regulatory proteins (IRPs). Here, we describe a mechanism of FBXL5 regulation involving its interaction with the cytosolic Fe-S cluster assembly (CIA) targeting complex composed of MMS19, FAM96B, and CIAO1. We demonstrate that the CIA-targeting complex promotes the ability of FBXL5 to degrade IRPs. In addition, the FBXL5-CIA-targeting complex interaction is regulated by oxygen (O (Copyright © 2019 Elsevier Inc. All rights reserved.) |
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| معلومات مُعتمدة: | R01 GM089778 United States GM NIGMS NIH HHS; R01 GM112763 United States GM NIGMS NIH HHS; T32 GM007185 United States GM NIGMS NIH HHS |
| فهرسة مساهمة: | Keywords: CIA-targeting complex; CIAO1; FAM96B; FBXL5; IRP1; IRP2; MMS19; hypoxia; iron homeostasis; iron metabolism |
| المشرفين على المادة: | 0 (ASF1A protein, human) 0 (Cell Cycle Proteins) 0 (F-Box Proteins) 0 (FBXL5 protein, human) 0 (Iron-Regulatory Proteins) 0 (Iron-Sulfur Proteins) 0 (Molecular Chaperones) 0 (Multiprotein Complexes) 0 (Transcription Factors) E1UOL152H7 (Iron) EC 2.3.2.23 (Ubiquitin-Protein Ligase Complexes) S88TT14065 (Oxygen) |
| تواريخ الأحداث: | Date Created: 20190624 Date Completed: 20200124 Latest Revision: 20200725 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC6660392 |
| DOI: | 10.1016/j.molcel.2019.05.020 |
| PMID: | 31229404 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1097-4164 |
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| DOI: | 10.1016/j.molcel.2019.05.020 |