دورية أكاديمية
أعرض في EDS

Incident infection following acute kidney injury with recovery to baseline creatinine: A propensity score matched analysis.

التفاصيل البيبلوغرافية
العنوان: Incident infection following acute kidney injury with recovery to baseline creatinine: A propensity score matched analysis.
المؤلفون: Griffin BR; Division of Renal Diseases and Hypertension, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, United States of America., You Z; Division of Renal Diseases and Hypertension, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, United States of America., Holmen J; Intermountain Healthcare System, Salt Lake City, UT, United States of America., SooHoo M; Department of Pediatrics, Children's Hospital Colorado, Aurora, CO, United States of America., Gist KM; Department of Pediatrics, Children's Hospital Colorado, Aurora, CO, United States of America., Colbert JF; Division of Infectious Diseases, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, United States of America., Chonchol M; Division of Renal Diseases and Hypertension, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, United States of America., Faubel S; Division of Renal Diseases and Hypertension, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, United States of America.; Renal Section, VA Eastern Colorado Health Care System, Denver, CO, United States of America., Jovanovich A; Division of Renal Diseases and Hypertension, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, United States of America.; Renal Section, VA Eastern Colorado Health Care System, Denver, CO, United States of America.
المصدر: PloS one [PLoS One] 2019 Jun 24; Vol. 14 (6), pp. e0217935. Date of Electronic Publication: 2019 Jun 24 (Print Publication: 2019).
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Propensity Score*, Acute Kidney Injury/*blood , Acute Kidney Injury/*complications , Creatinine/*blood , Infections/*blood , Infections/*complications, Case-Control Studies ; Female ; Humans ; Male ; Matched-Pair Analysis ; Middle Aged ; Survival Analysis
مستخلص: Background: Severe acute kidney injury (AKI) is associated with subsequent infection. Whether AKI followed by a return to baseline creatinine is associated with incident infection is unknown.
Objective: We hypothesized that risk of both short and long term infection would be higher among patients with AKI and return to baseline creatinine than in propensity score matched peers without AKI in the year following a non-infectious hospital admission.
Design: Retrospective, propensity score matched cohort study.
Participants: We identified 494 patients who were hospitalized between January 1, 1999 and December 31, 2009 and had AKI followed by return to baseline creatinine. These were propensity score matched to controls without AKI.
Main Measures: The predictor variable was AKI defined by International Classification of Diseases, Ninth Revision (ICD-9) codes and by the Kidney Disease Improving Global Outcomes definition, with return to baseline creatinine defined as a decrease in serum creatinine level to within 10% of the baseline value within 7 days of hospital discharge. The outcome variable was incident infection defined by ICD-9 code within 1 year of hospital discharge.
Results: AKI followed by return to baseline creatinine was associated with a 4.5-fold increased odds ratio for infection (odds ratio 4.53 [95% CI, 2.43-8.45]; p<0.0001) within 30 days following discharge. The association between AKI and subsequent infection remained significant at 31-60 days and 91 to 365 days but not during 61-90 days following discharge.
Conclusion: Among patients from an integrated health care delivery system, non-infectious AKI followed by return to baseline creatinine was associated with an increased odds ratio for infection in the year following discharge.
Competing Interests: The author, John Holmen, is employed by Intermountain Healthcare System. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
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معلومات مُعتمدة: IK2 CX001030 United States CX CSRD VA; K08 AG061144 United States AG NIA NIH HHS; R03 AG056353 United States AG NIA NIH HHS; T32 DK007135 United States DK NIDDK NIH HHS
المشرفين على المادة: AYI8EX34EU (Creatinine)
تواريخ الأحداث: Date Created: 20190625 Date Completed: 20200211 Latest Revision: 20220408
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC6590794
DOI: 10.1371/journal.pone.0217935
PMID: 31233518
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0217935