التفاصيل البيبلوغرافية
| العنوان: |
Unmasking senescence: context-dependent effects of SASP in cancer. |
| المؤلفون: |
Faget DV; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA., Ren Q; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA., Stewart SA; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA. sheila.stewart@wustl.edu.; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. sheila.stewart@wustl.edu.; ICCE Institute, Washington University School of Medicine, St. Louis, MO, USA. sheila.stewart@wustl.edu.; Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA. sheila.stewart@wustl.edu. |
| المصدر: |
Nature reviews. Cancer [Nat Rev Cancer] 2019 Aug; Vol. 19 (8), pp. 439-453. Date of Electronic Publication: 2019 Jun 24. |
| نوع المنشور: |
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101124168 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-1768 (Electronic) Linking ISSN: 1474175X NLM ISO Abbreviation: Nat Rev Cancer Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: London, UK : Nature Pub. Group, [c2001- |
| مواضيع طبية MeSH: |
Cell Transformation, Neoplastic*, Cellular Senescence/*genetics , Neoplasms/*pathology, Antineoplastic Agents/pharmacology ; Apoptosis ; DNA Damage ; Disease Progression ; Fibroblasts/metabolism ; Humans ; Immune System ; Neoplasms/genetics ; Phenotype ; Promoter Regions, Genetic |
| مستخلص: |
Cellular senescence plays a critical role in tumorigenesis. Once thought of as a tissue culture artefact by some researchers, senescence is now a major field of study. Although there are common molecular mechanisms that enforce the growth arrest that characterizes the phenotype, the impact of senescence is varied and can, in some instances, have opposite effects on tumorigenesis. It has become clearer that the cell of origin and the tissue in question dictate the impact of senescence on tumorigenesis. In this Review, we unravel this complexity by focusing on how senescence impacts tumorigenesis when it arises within incipient tumour cells versus stromal cells, and how these roles can change in different stages of disease progression. In addition, we highlight the diversity of the senescent phenotype and its functional output beyond growth arrest: the senescence-associated secretory phenotype (SASP). Fortunately, a number of new genetic and pharmacologic tools have been developed that are now allowing the senescence phenotype to be parsed further. |
| معلومات مُعتمدة: |
R01 AG059244 United States AG NIA NIH HHS |
| المشرفين على المادة: |
0 (Antineoplastic Agents) |
| تواريخ الأحداث: |
Date Created: 20190626 Date Completed: 20191223 Latest Revision: 20200617 |
| رمز التحديث: |
20240628 |
| DOI: |
10.1038/s41568-019-0156-2 |
| PMID: |
31235879 |
| قاعدة البيانات: |
MEDLINE |
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