دورية أكاديمية
أعرض في EDS

Integrated analysis of microRNA regulation and its interaction with mechanisms of epigenetic regulation in the etiology of systemic lupus erythematosus.

التفاصيل البيبلوغرافية
العنوان: Integrated analysis of microRNA regulation and its interaction with mechanisms of epigenetic regulation in the etiology of systemic lupus erythematosus.
المؤلفون: Navarro Quiroz E; Universidad Simon Bolivar, Basic and Biomedical Faculty, Barranquilla, Colombia., Navarro Quiroz R; CMCC- Centro de Matemática, Computação e Cognição, Laboratório do Biologia Computacional e Bioinformática-LBCB, Universidade Federal do ABC, Sao Paulo, Brazil., Pacheco Lugo L; Universidad Simon Bolivar, Basic and Biomedical Faculty, Barranquilla, Colombia., Aroca Martínez G; Universidad Simon Bolivar, Basic and Biomedical Faculty, Barranquilla, Colombia.; Clínica de la Costa, Department of Nephrology, Barranquilla, Colombia., Gómez Escorcia L; Universidad Simon Bolivar, Basic and Biomedical Faculty, Barranquilla, Colombia., Gonzalez Torres H; Universidad Simon Bolivar, Basic and Biomedical Faculty, Barranquilla, Colombia., Cadena Bonfanti A; Universidad Simon Bolivar, Basic and Biomedical Faculty, Barranquilla, Colombia.; Clínica de la Costa, Department of Nephrology, Barranquilla, Colombia., Marmolejo MDC; Universidad de Cadiz, Department of Biomedicine, Biotechnology and Public Health, Cadiz, Spain., Sanchez E; Universidad del Norte, School of Medicine, Barranquilla, Colombia., Villarreal Camacho JL; Universidad Libre, School of Medicine, Barranquilla, Colombia., Lorenzi H; Infectious Diseases Department, J. Craig Venter Institute, Rockville, Maryland, United States of America., Torres A; Universidad Simon Bolivar, Basic and Biomedical Faculty, Barranquilla, Colombia.; Universidad Popular del Cesar, Basic and Biomedical Faculty, Valledupar, Colombia., Navarro KF; Clínica de la Costa, Department of Nephrology, Barranquilla, Colombia.; ACCONP, Barranquilla, Colombia., Navarro Rodriguez P; ColNalPinillos, Mompós, Colombia., Villa JL; Procaps S.A., Research and Development, Barranquilla, Colombia., Fernández-Ponce C; Universidad de Cadiz, Department of Biomedicine, Biotechnology and Public Health, Cadiz, Spain.
المصدر: PloS one [PLoS One] 2019 Jun 25; Vol. 14 (6), pp. e0218116. Date of Electronic Publication: 2019 Jun 25 (Print Publication: 2019).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Epigenesis, Genetic*, Lupus Erythematosus, Systemic/*genetics , MicroRNAs/*genetics, Databases, Genetic ; Gene Ontology ; Gene Regulatory Networks ; Genetic Association Studies ; Humans ; MicroRNAs/metabolism ; Protein Processing, Post-Translational
مستخلص: The aim of this study was to identity in silico the relationships among microRNAs (miRNAs) and genes encoding transcription factors, ubiquitylation, DNA methylation, and histone modifications in systemic lupus erythematosus (SLE). To identify miRNA dysregulation in SLE, we used miR2Disease and PhenomiR for information about miRNAs exhibiting differential regulation in disease and other biological processes, and HMDD for information about experimentally supported human miRNA-disease association data from genetics, epigenetics, circulating miRNAs, and miRNA-target interactions. This information was incorporated into the miRNA analysis. High-throughput sequencing revealed circulating miRNAs associated with kidney damage in patients with SLE. As the main finding of our in silico analysis of miRNAs differentially expressed in SLE and their interactions with disease-susceptibility genes, post-translational modifications, and transcription factors; we highlight 226 miRNAs associated with genes and processes. Moreover, we highlight that alterations of miRNAs such as hsa-miR-30a-5p, hsa-miR-16-5p, hsa-miR-142-5p, and hsa-miR-324-3p are most commonly associated with post-translational modifications. In addition, altered miRNAs that are most frequently associated with susceptibility-related genes are hsa-miR-16-5p, hsa-miR-374a-5p, hsa-miR-34a-5p, hsa-miR-31-5p, and hsa-miR-1-3p.
Competing Interests: The authors have declared that no competing interests exist.
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المشرفين على المادة: 0 (MicroRNAs)
تواريخ الأحداث: Date Created: 20190626 Date Completed: 20200212 Latest Revision: 20200309
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC6592600
DOI: 10.1371/journal.pone.0218116
PMID: 31237906
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0218116