دورية أكاديمية
أعرض في EDS

Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging.

التفاصيل البيبلوغرافية
العنوان: Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging.
المؤلفون: Lepletier A; Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash University, Clayton, Melbourne, VIC 3800, Australia., Hun ML; Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash University, Clayton, Melbourne, VIC 3800, Australia., Hammett MV; Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash University, Clayton, Melbourne, VIC 3800, Australia., Wong K; Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash University, Clayton, Melbourne, VIC 3800, Australia., Naeem H; Monash Bioinformatics Platform, Monash University, Clayton, Melbourne, VIC 3800, Australia., Hedger M; Centre for Reproductive Health, Hudson Institute of Medical Research, Clayton, Melbourne, VIC 3168, Australia., Loveland K; Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash University, Clayton, Melbourne, VIC 3800, Australia; Centre for Reproductive Health, Hudson Institute of Medical Research, Clayton, Melbourne, VIC 3168, Australia; Department of Molecular and Translational Sciences, School of Clinical Sciences, Monash University, Clayton, Melbourne, VIC 3800, Australia., Chidgey AP; Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash University, Clayton, Melbourne, VIC 3800, Australia. Electronic address: ann.chidgey@monash.edu.
المصدر: Cell reports [Cell Rep] 2019 Jun 25; Vol. 27 (13), pp. 3887-3901.e4.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, c 2012-
مواضيع طبية MeSH: Cell Differentiation* , Signal Transduction*, Activins/*metabolism , Aging/*metabolism , Bone Morphogenetic Protein 4/*metabolism , Epithelial Cells/*metabolism , Follistatin/*metabolism , Stem Cells/*metabolism , Thymus Gland/*metabolism, Animals ; Epithelial Cells/cytology ; Female ; Mice ; Mice, Inbred BALB C ; Stem Cells/cytology ; Thymus Gland/cytology
مستخلص: A key feature of immune functional impairment with age is the progressive involution of thymic tissue responsible for naive T cell production. In this study, we identify two major phases of thymic epithelial cell (TEC) loss during aging: a block in mature TEC differentiation from the pool of immature precursors, occurring at the onset of puberty, followed by impaired bipotent TEC progenitor differentiation and depletion of Sca-1 lo cTEC and mTEC lineage-specific precursors. We reveal that an increase in follistatin production by aging TECs contributes to their own demise. TEC loss occurs primarily through the antagonism of activin A signaling, which we show is required for TEC maturation and acts in dissonance to BMP4, which promotes the maintenance of TEC progenitors. These results support a model in which an imbalance of activin A and BMP4 signaling underpins the degeneration of postnatal TEC maintenance during aging, and its reversal enables the transient replenishment of mature TECs.
(Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: BMP4; activin A; androgen blockade; follistatin; immune aging; thymic epithelial cells; thymic epithelial progenitor; thymic involution; thymus; thymus regeneration
المشرفين على المادة: 0 (Bmp4 protein, mouse)
0 (Bone Morphogenetic Protein 4)
0 (Follistatin)
0 (activin A)
104625-48-1 (Activins)
تواريخ الأحداث: Date Created: 20190627 Date Completed: 20200730 Latest Revision: 20200730
رمز التحديث: 20221213
DOI: 10.1016/j.celrep.2019.05.045
PMID: 31242421
قاعدة البيانات: MEDLINE
الوصف
تدمد:2211-1247
DOI:10.1016/j.celrep.2019.05.045