دورية أكاديمية
Discovery of New Triterpenoid Saponins Isolated from Maesa japonica with Antifungal Activity against Rice Blast Fungus Magnaporthe oryzae .
| العنوان: | Discovery of New Triterpenoid Saponins Isolated from Maesa japonica with Antifungal Activity against Rice Blast Fungus Magnaporthe oryzae . |
|---|---|
| المؤلفون: | Ngo MT; Center for Eco-friendly New Materials , Korea Research Institute of Chemical Technology , Daejeon 34114 , Korea.; Department of Medicinal Chemistry and Pharmacology , University Science and Technology , Daejeon 34113 , Korea., Han JW; Center for Eco-friendly New Materials , Korea Research Institute of Chemical Technology , Daejeon 34114 , Korea., Yoon S; Center for Eco-friendly New Materials , Korea Research Institute of Chemical Technology , Daejeon 34114 , Korea., Bae S; Center for Eco-friendly New Materials , Korea Research Institute of Chemical Technology , Daejeon 34114 , Korea.; Department of Medicinal Chemistry and Pharmacology , University Science and Technology , Daejeon 34113 , Korea., Kim SY; Biological and Genetic Resources Utilization Division , National Institute of Biological Resources , Incheon 22869 , Korea., Kim H; Center for Eco-friendly New Materials , Korea Research Institute of Chemical Technology , Daejeon 34114 , Korea.; Department of Medicinal Chemistry and Pharmacology , University Science and Technology , Daejeon 34113 , Korea., Choi GJ; Center for Eco-friendly New Materials , Korea Research Institute of Chemical Technology , Daejeon 34114 , Korea.; Department of Medicinal Chemistry and Pharmacology , University Science and Technology , Daejeon 34113 , Korea. |
| المصدر: | Journal of agricultural and food chemistry [J Agric Food Chem] 2019 Jul 10; Vol. 67 (27), pp. 7706-7715. Date of Electronic Publication: 2019 Jun 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem |
| أسماء مطبوعة: | Original Publication: Washington, American Chemical Society. |
| مواضيع طبية MeSH: | Fungicides, Industrial*, Maesa/*chemistry , Magnaporthe/*drug effects , Oryza/*microbiology , Plant Extracts/*pharmacology , Saponins/*pharmacology, Acylation ; Magnetic Resonance Spectroscopy ; Molecular Structure ; Plant Extracts/chemistry ; Saponins/chemistry ; Saponins/isolation & purification ; Triterpenes/isolation & purification ; Triterpenes/pharmacology |
| مستخلص: | While searching for new antifungal compounds, we revealed that a methanol extract of plant species Maesa japonica has a potent antifungal activity in vivo against rice blast fungus Magnaporthe oryzae . To identify the antifungal substances, the methanol extract of M. japonica was extracted by organic solvents, and consequently, six active compounds were isolated from the n -butanol layer. The isolated compounds were five new acylated triterpenoid saponins including maejaposide I ( 1 ), maejaposides C-1, C-2, and C-3 ( 2 - 4 ), and maejaposide A-1 ( 5 ), along with a known one, maejaposide A ( 6 ). These chemical structures were determined by NMR and a comparison of their NMR and MS data with those reported in the literature. Based on the in vitro antifungal bioassay, the five compounds ( 2 - 6 ) exhibited strong antifungal activity against M. oryzae with MIC values ranging from 4 to 32 μg/mL, except for maejaposide I ( 1 ) (MIC > 250 μg/mL). When the compounds were evaluated at concentrations of 125, 250, and 500 μg/mL for an in vivo antifungal activity against rice blast, compounds 2 - 6 strongly reduced the development of blast by at least 85% to 98% compared to the untreated control. However, compound 1 did not show any in vivo antifungal activity up to a concentration of 500 μg/mL. Taken together, our results suggest that the methanol extract of M. japonica and the new acylated triterpenoid saponins can be used as a source for the development of natural fungicides. |
| فهرسة مساهمة: | Keywords: Maesa japonica; antifungal; plant disease control; rice blast; saponins |
| المشرفين على المادة: | 0 (Fungicides, Industrial) 0 (Plant Extracts) 0 (Saponins) 0 (Triterpenes) |
| تواريخ الأحداث: | Date Created: 20190628 Date Completed: 20190812 Latest Revision: 20190812 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1021/acs.jafc.9b02236 |
| PMID: | 31246022 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1520-5118 |
|---|---|
| DOI: | 10.1021/acs.jafc.9b02236 |