دورية أكاديمية
Layer-specific longitudinal strain in Anderson-Fabry disease at diagnosis: A speckle tracking echocardiography analysis.
| العنوان: | Layer-specific longitudinal strain in Anderson-Fabry disease at diagnosis: A speckle tracking echocardiography analysis. |
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| المؤلفون: | Esposito R; Department of Advanced Biomedical Sciences, University Federico II, Naples, Italy.; Mediterranea Cardiocentro, Naples, Italy., Santoro C; Department of Advanced Biomedical Sciences, University Federico II, Naples, Italy., Sorrentino R; Department of Advanced Biomedical Sciences, University Federico II, Naples, Italy., Riccio E; Department of Public Medicine, University Federico II, Naples, Italy., Citro R; Department of Cardiology, University Hospital 'San Giovanni di Dio e Ruggi d'Aragona', Salerno, Italy., Buonauro A; Department of Advanced Biomedical Sciences, University Federico II, Naples, Italy., Di Risi T; Department of Molecular Medicine and Medical Biology, University Federico II, Naples, Italy., Imbriaco M; Department of Advanced Biomedical Sciences, University Federico II, Naples, Italy., Trimarco B; Department of Advanced Biomedical Sciences, University Federico II, Naples, Italy., Pisani A; Department of Public Medicine, University Federico II, Naples, Italy., Galderisi M; Department of Advanced Biomedical Sciences, University Federico II, Naples, Italy. |
| مؤلفون مشاركون: | Anderson-Fabry Federico II Naples, ITalY (AFFINIITY) Group |
| المصدر: | Echocardiography (Mount Kisco, N.Y.) [Echocardiography] 2019 Jul; Vol. 36 (7), pp. 1273-1281. Date of Electronic Publication: 2019 Jun 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 8511187 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-8175 (Electronic) Linking ISSN: 07422822 NLM ISO Abbreviation: Echocardiography Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Hoboken, NJ : Wiley-Blackwell Original Publication: Mount Kisco, N.Y. : Futura Pub. Co., [c1984- |
| مواضيع طبية MeSH: | Echocardiography/*methods , Fabry Disease/*diagnostic imaging , Heart Diseases/*diagnostic imaging, Adult ; Case-Control Studies ; Fabry Disease/physiopathology ; Female ; Heart Diseases/physiopathology ; Humans ; Male |
| مستخلص: | Background: Speckle tracking advancements make now available the analysis of layer-specific myocardial deformation. This study investigated multilayer longitudinal strain in Anderson-Fabry disease (AFD) patients at diagnosis. Methods: In a case-control study, 33 newly diagnosed, untreated AFD patients and 33 healthy age- and sex-matched healthy controls underwent a complete echocardiogram, including assessment of left ventricular (LV) transmural global longitudinal strain (GLS), subendocardial longitudinal strain (LSsubendo), subepicardial longitudinal strain (LSsubepi), and strain gradient (LSsubendo-LSsubpepi). Results: Anderson-Fabry disease patients had similar blood pressure, heart rate, and ejection fraction but higher body mass index in comparison with controls. LV mass index, maximal, and relative wall thickness were significantly greater in AFD patients. LSsubendo was significantly higher than LSsubepi in both groups, but GLS (P < 0.0001), LSsubendo (P = 0.003), and particularly LSsubepi (21.4 ± 1.7 vs 18.8 ± 1.4%, P < 0.0001) were lower in AFD patients than in controls. Accordingly, LS gradient was higher in AFD patients (P = 0.003). Three patients symptomatic for dyspnoea presented a combination of LV hypertrophy and reduced LSsubepi. After adjusting for confounders by multivariate analyses, LV mass index or maximal wall thickness were independently and inversely associated with transmural GLS and LSsubepi, but not with LSsubendo in the AFD group. At receiver operating curve curves, LSsubepi best discriminated AFD and normals. Conclusions: In newly diagnosed, untreated AFD patients, layer-specific strain imaging highlights an impairment of LV longitudinal deformation, mainly involving subepicardial strain and causing increase in longitudinal strain myocardial gradient. These findings could be useful for identifying the mechanisms underlying early LV dysfunction in AFD patients. (© 2019 Wiley Periodicals, Inc.) |
| فهرسة مساهمة: | Keywords: Fabry disease; left ventricular hypertrophy; left ventricular strain; left ventricular systolic function; speckle tracking echocardiography |
| تواريخ الأحداث: | Date Created: 20190628 Date Completed: 20201001 Latest Revision: 20201001 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1111/echo.14399 |
| PMID: | 31246327 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1540-8175 |
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| DOI: | 10.1111/echo.14399 |