دورية أكاديمية
Curcumin pre-treatment modulate the activities of adenine nucleotide and nucleoside degradation enzymes in lymphocyte of rats infected with Trypanosoma evansi.
| العنوان: | Curcumin pre-treatment modulate the activities of adenine nucleotide and nucleoside degradation enzymes in lymphocyte of rats infected with Trypanosoma evansi. |
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| المؤلفون: | Wolkmer P; Veterinary Medicine, University of Cruz Alta, Rio Grande do Sul, Brazil. Electronic address: pwolkmer@unicruz.edu.br., Pereira AB; Department of Small Animals, Federal University of Santa Maria, Brazil., da Silva CB; Department of Small Animals, Federal University of Santa Maria, Brazil., Paim FC; Department of Small Animals, Federal University of Santa Maria, Brazil., Palma HE; Veterinary Medicine, University of Cruz Alta, Rio Grande do Sul, Brazil., Bueno A; Department of Small Animals, Federal University of Santa Maria, Brazil., Emanuelli MP; Department of Small Animals, Federal University of Santa Maria, Brazil., Siqueira LC; Rural Development post-graduation program, University of Cruz Alta, Rio Grande do Sul, Brazil., Monteiro SG; Department of Microbiology and Parasitology, Federal University of Santa Maria, Brazil., Andrade CM; Veterinary Medicine, University of Cruz Alta, Rio Grande do Sul, Brazil. |
| المصدر: | Parasitology international [Parasitol Int] 2019 Dec; Vol. 73, pp. 101948. Date of Electronic Publication: 2019 Jun 24. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9708549 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-0329 (Electronic) Linking ISSN: 13835769 NLM ISO Abbreviation: Parasitol Int Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; New York : Elsevier, c1997- |
| مواضيع طبية MeSH: | Adenine Nucleotides/*metabolism , Adenosine Triphosphatases/*metabolism , Curcumin/*metabolism , Immunomodulation/*drug effects , Trypanosomiasis/*metabolism, Animal Feed/analysis ; Animals ; Curcumin/administration & dosage ; Diet/veterinary ; Dietary Supplements/analysis ; Dose-Response Relationship, Drug ; Lymphocytes/parasitology ; Male ; Random Allocation ; Rats ; Rats, Wistar ; Trypanosoma/physiology |
| مستخلص: | This study aimed to evaluate nucleoside triphosphate diphosphohydrolase (NTPDase) and adenosine deaminase (ADA) activities in lymphocytes from rats supplemented or not with curcumin 30 days prior to experimental infection with Trypanosoma evansi. Thirty-two adult male Wistar rats were divided in four groups. The pre-infection group 20 (PreI20) received orally 20 mg/kg of curcumin and pre-infection group 60 (PreI60) received orally 60 mg/kg of curcumin for 30 days prior inoculation with T. evansi. The infected e non-infected control groups received only oral vehicle for 30 days. Trypanosoma evansi infected groups were inoculated intraperitoneally with 0.2 ml of blood with 1 × 10 6 parasites. After inoculation the treatment of the groups continued until the day of euthanasia (15 days). The results showed that curcumin pre-treatment, with both doses, reduced (P < .05) NTPDase and increased (P < .05) ADA activity in lymphocytes of treated groups when compared to untreated and infected animals (control). The results of this study support the evidence that the regulation of ATP and adenosine levels by NTPDase and ADA activities appear to be important to modulate the immune response in T. evansi infection, once the treatment with curcumin maintained the NTPDase activity reduced and enhanced ADA activity in lymphocytes. It is possible to conclude that the use of curcumin prior to infection with T. evansi induces immunomodulatory effects, favoring the response against the parasite. (Copyright © 2019 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: ADA; NTPDase; Purinergic system; Trypanosomiasis |
| المشرفين على المادة: | 0 (Adenine Nucleotides) EC 3.6.1.- (Adenosine Triphosphatases) EC 3.6.1.- (ectoATPase) IT942ZTH98 (Curcumin) |
| تواريخ الأحداث: | Date Created: 20190628 Date Completed: 20191206 Latest Revision: 20191217 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.parint.2019.101948 |
| PMID: | 31247308 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1873-0329 |
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| DOI: | 10.1016/j.parint.2019.101948 |