دورية أكاديمية
أعرض في EDS

Hypothermic Oxygenated Machine Perfusion of Liver Grafts from Brain-Dead Donors.

التفاصيل البيبلوغرافية
العنوان: Hypothermic Oxygenated Machine Perfusion of Liver Grafts from Brain-Dead Donors.
المؤلفون: Patrono D; General Surgery 2U - Liver Transplant Unit, A.O.U. Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy., Surra A; General Surgery 2U - Liver Transplant Unit, A.O.U. Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy., Catalano G; General Surgery 2U - Liver Transplant Unit, A.O.U. Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy., Rizza G; General Surgery 2U - Liver Transplant Unit, A.O.U. Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy., Berchialla P; Department of Clinical and Biological Sciences, University of Turin, Turin, Italy., Martini S; Gastrohepatology Unit, A.O.U. Città della Salute e della Scienza di Torino, Turin, Italy., Tandoi F; General Surgery 2U - Liver Transplant Unit, A.O.U. Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy., Lupo F; General Surgery 2U - Liver Transplant Unit, A.O.U. Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy., Mirabella S; General Surgery 2U - Liver Transplant Unit, A.O.U. Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy., Stratta C; Anesthesia Department 2, A.O.U. Città della Salute e della Scienza di Torino, Turin, Italy., Salizzoni M; General Surgery 2U - Liver Transplant Unit, A.O.U. Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy., Romagnoli R; General Surgery 2U - Liver Transplant Unit, A.O.U. Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy. renato.romagnoli@unito.it.
المصدر: Scientific reports [Sci Rep] 2019 Jun 27; Vol. 9 (1), pp. 9337. Date of Electronic Publication: 2019 Jun 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Brain Death* , Graft Survival* , Hypothermia, Induced* , Liver Transplantation*/methods , Organ Preservation* , Oxygenators*, Perfusion/*methods, Aged ; Bayes Theorem ; Female ; Humans ; Liver Function Tests ; Male ; Middle Aged ; Perfusion/instrumentation ; Postoperative Complications ; Tissue Donors ; Vascular Resistance
مستخلص: Hypothermic oxygenated machine perfusion (HOPE) was introduced in liver transplantation (LT) to mitigate ischemia-reperfusion injury. Available clinical data mainly concern LT with donors after circulatory-determined death, whereas data on brain-dead donors (DBD) are scarce. To assess the impact of end-ischemic HOPE in DBD LT, data on primary adult LTs performed between March 2016 and June 2018 were analyzed. HOPE was used in selected cases of donor age >80 years, apparent severe graft steatosis, or ischemia time ≥10 hours. Outcomes of HOPE-treated cases were compared with those after static cold storage. Propensity score matching (1:2) and Bayesian model averaging were used to overcome selection bias. During the study period, 25 (8.5%) out of 294 grafts were treated with HOPE. After matching, HOPE was associated with a lower severe post-reperfusion syndrome (PRS) rate (4% versus 20%, p = 0.13) and stage 2-3 acute kidney injury (AKI) (16% versus 42%, p = 0.046). Furthermore, Bayesian model averaging showed lower transaminases peak and a lower early allograft dysfunction (EAD) rate after HOPE. A steeper decline in arterial graft resistance throughout perfusion was associated with lower EAD rate. HOPE determines a significant reduction of ischemia reperfusion injury in DBD LT.
References: Ann Intern Med. 2002 Oct 15;137(8):693-5. (PMID: 12379071)
Liver Transpl. 2010 Aug;16(8):943-9. (PMID: 20677285)
Am J Transplant. 2006 Apr;6(4):783-90. (PMID: 16539636)
Am J Transplant. 2016 Jun;16(6):1779-87. (PMID: 26752191)
Liver Transpl. 2007 May;13(5):708-18. (PMID: 17457932)
HPB (Oxford). 2017 Jun;19(6):538-546. (PMID: 28351756)
Int J Mol Sci. 2018 Nov 12;19(11):. (PMID: 30424553)
Liver Transpl. 2008 Apr;14(4):504-8. (PMID: 18383079)
Transpl Int. 2010 Jan;23(1):14-22. (PMID: 19691661)
Transplantation. 2016 Apr;100(4):825-35. (PMID: 26863473)
Transpl Int. 2013 Nov;26(11):1116-25. (PMID: 24033747)
J Hepatol. 2015 Jul;63(1):265-75. (PMID: 25770660)
Gastroenterology. 2019 May;156(6):1542-1547. (PMID: 30660724)
Ann Surg. 2006 Jun;243(6):748-53; discussion 753-5. (PMID: 16772778)
Nature. 2014 Nov 20;515(7527):431-435. (PMID: 25383517)
Am J Transplant. 2011 Oct;11(10):2214-20. (PMID: 21834917)
Liver Transpl. 2018 Dec;24(12):1699-1715. (PMID: 30058119)
Multivariate Behav Res. 2014 Nov-Dec;49(6):505-17. (PMID: 26735355)
Liver Transpl. 2017 May;23(5):634-644. (PMID: 28124458)
Transplantation. 2017 May;101(5):1084-1098. (PMID: 28437389)
Am J Transplant. 2014 Dec;14(12):2846-54. (PMID: 25283987)
Am J Transplant. 2013 Feb;13(2):253-65. (PMID: 23331505)
Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt B):1507-1515. (PMID: 28645651)
J Hepatol. 2013 Nov;59(5):984-91. (PMID: 23820408)
Ann Surg. 2015 Nov;262(5):764-70; discussion 770-1. (PMID: 26583664)
Am J Transplant. 2013 Jun;13(6):1450-60. (PMID: 23617781)
J Hepatol. 2014 Apr;60(4):765-72. (PMID: 24295869)
Curr Opin Organ Transplant. 2016 Jun;21(3):322-8. (PMID: 27050485)
Exp Clin Transplant. 2018 Apr;16(2):172-176. (PMID: 29108514)
Transpl Int. 2017 Jul;30(7):660-669. (PMID: 27864895)
Nephron Clin Pract. 2012;120(4):c179-84. (PMID: 22890468)
Liver Transpl. 2018 Nov;24(11):1523-1535. (PMID: 30022597)
Am J Transplant. 2015 Jan;15(1):161-9. (PMID: 25521639)
Am J Transplant. 2010 Feb;10(2):372-81. (PMID: 19958323)
Transplantation. 2017 Jul;101(7):e223-e224. (PMID: 28353493)
Curr Transplant Rep. 2018;5(1):93-102. (PMID: 29564206)
Transpl Int. 2019 Feb;32(2):193-205. (PMID: 30198069)
Liver Transpl. 2018 May;24(5):655-664. (PMID: 29369470)
Ann Surg. 2004 Aug;240(2):205-13. (PMID: 15273542)
Am J Transplant. 2018 Aug;18(8):2005-2020. (PMID: 29419931)
J Hepatol. 2019 Jan;70(1):50-57. (PMID: 30342115)
Ann Surg. 2014 Nov;260(5):931-7; discussion 937-8. (PMID: 25243553)
Liver Transpl. 2019 Mar;25(3):436-449. (PMID: 30362649)
Liver Int. 2016 Oct;36(10):1481-9. (PMID: 27028510)
Curr Transplant Rep. 2015;2(1):52-62. (PMID: 26097802)
Cryobiology. 2009 Jun;58(3):331-6. (PMID: 19318091)
Transplant Direct. 2018 Apr 23;4(5):e345. (PMID: 29796416)
Liver Transpl. 2009 Dec;15(12):1688-95. (PMID: 19938120)
Liver Transpl. 2016 Jul;22(7):1025-33. (PMID: 27082839)
Br J Surg. 2017 Jun;104(7):907-917. (PMID: 28394402)
Am J Transplant. 2009 Feb;9(2):318-26. (PMID: 19120079)
Curr Opin Organ Transplant. 2013 Apr;18(2):168-73. (PMID: 23385886)
Nature. 2018 May;557(7703):50-56. (PMID: 29670285)
Ann Surg. 2011 Nov;254(5):745-53; discussion 753. (PMID: 22042468)
Semin Liver Dis. 2018 Aug;38(3):260-269. (PMID: 30041278)
Liver Transpl. 2010 Jul;16(7):874-84. (PMID: 20583086)
Biom J. 2017 Sep;59(5):967-985. (PMID: 28436047)
Liver Transpl. 2019 May;25(5):771-786. (PMID: 30740859)
J Hepatol. 2017 Sep 21;:. (PMID: 28870676)
Cell Metab. 2016 Feb 9;23(2):254-63. (PMID: 26777689)
Am J Transplant. 2019 Apr;19(4):1061-1071. (PMID: 30411502)
J Hepatol. 2011 May;54(5):1055-62. (PMID: 21145846)
PLoS One. 2014 Feb 14;9(2):e88521. (PMID: 24551114)
J Hepatol. 2013 Feb;58(2):278-86. (PMID: 23063573)
تواريخ الأحداث: Date Created: 20190629 Date Completed: 20201023 Latest Revision: 20210110
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC6597580
DOI: 10.1038/s41598-019-45843-3
PMID: 31249370
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-019-45843-3