دورية أكاديمية
Increased Intracranial Pressure Damages Optic Nerve Structural Support.
| العنوان: | Increased Intracranial Pressure Damages Optic Nerve Structural Support. |
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| المؤلفون: | East L; Medical College of Georgia, Augusta University, Augusta, Georgia., Lyon M; Department of Emergency Medicine, Augusta University, Augusta, Georgia.; Center for Ultrasound Education, Augusta University, Augusta, Georgia., Agrawal P; Medical College of Georgia, Augusta University, Augusta, Georgia., Islam Z; Medical College of Georgia, Augusta University, Augusta, Georgia., Newell M; Medical College of Georgia, Augusta University, Augusta, Georgia., Hockman T; Division of Laboratory Animal Services, Augusta University, Augusta, Georgia., Heger IM; Department of Neurosurgery, Augusta University, Augusta, Georgia., Xu H; Department of Population Health Sciences, Augusta University, Augusta, Georgia., Kuchinski AM; Department of Emergency Medicine, Augusta University, Augusta, Georgia., Gibson RW; Department of Emergency Medicine, Augusta University, Augusta, Georgia. |
| المصدر: | Journal of neurotrauma [J Neurotrauma] 2019 Nov 15; Vol. 36 (22), pp. 3132-3137. Date of Electronic Publication: 2019 Jul 31. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mary Ann Liebert Country of Publication: United States NLM ID: 8811626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-9042 (Electronic) Linking ISSN: 08977151 NLM ISO Abbreviation: J Neurotrauma Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Larchmont, NY : Mary Ann Liebert Original Publication: New York, NY : Mary Ann Liebert, c1988- |
| مواضيع طبية MeSH: | Intracranial Hypertension/*complications , Optic Nerve/*pathology , Optic Nerve/*ultrastructure, Animals ; Microscopy, Electron, Scanning ; Porosity ; Swine |
| مستخلص: | Optic nerve sheath diameter (ONSD) is used clinically as a noninvasive measure for elevated intracranial pressure (ICP). This study had two purposes: to investigate the immediate effects optic nerve sheath (ONS) dilation post-ICP increase on trabecular fibers connecting the optic nerve to the ONS and to document any changes in these fibers 30 days post-increased ICP. In a swine model, ICP was increased by inflating a Foley catheter balloon in the epidural space. Three control pigs received the catheter insertion without inflation (no increase in ICP) and four experimental pigs received the catheter with inflation (increased ICP). The control and two randomly selected pigs with increased ICP were euthanized immediately after the procedure. The two other pigs were euthanized 30 days post-catheter inflation. For all pigs, the ONS was removed and imaged using a scanning electron microscope, calculating percent porosity values. Porosity values for the experimental groups (Immediately measured [IM] μ = 0.5749; Delayed measured [DM] μ = 0.5714) were larger than the control group (μ = 0.4336) and statistically significant (IM vs. Control, p = 0.0018; DM vs. Control, p = 0.0092). There was no significant difference ( p = 0.9485) in porosity of the DM group when compared with the IM group. This study demonstrated that the trabecular fibers immediately post-increased ICP (ONS dilation) were more porous than the control and remained statistically different (more porous) after 30 days. These results suggest a structural change that occurs in the ONS with elevations in ICP. |
| فهرسة مساهمة: | Keywords: intracranial pressure; neuroanatomy; ocular sheath fibers; traumatic brain injury; ultrasound |
| تواريخ الأحداث: | Date Created: 20190702 Date Completed: 20201120 Latest Revision: 20201120 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1089/neu.2019.6490 |
| PMID: | 31256706 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1557-9042 |
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| DOI: | 10.1089/neu.2019.6490 |