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Therapeutic bullfrog oil-based nanoemulsion for oral application: Development, characterization and stability.

التفاصيل البيبلوغرافية
العنوان: Therapeutic bullfrog oil-based nanoemulsion for oral application: Development, characterization and stability.
المؤلفون: Rutckeviski R; Universidade Federal do Rio Grande do Norte (UFRN), Programa de Pós-graduação em Ciências Farmacêuticas, Departamento de Farmácia, 59010-180, Natal-RN, Brazil.; UFRN, Laboratório de Sistemas Dispersos (LaSiD), Departamento de Farmácia59010-180, Natal-RN, Brazil., Xavier FH; UFRN, Laboratório de Sistemas Dispersos (LaSiD), Departamento de Farmácia59010-180, Natal-RN, Brazil., Morais ARDV; UFRN, Laboratório de Sistemas Dispersos (LaSiD), Departamento de Farmácia59010-180, Natal-RN, Brazil.; UFRN, Programa de Pós-graduação em Nanotecnologia Farmacêutica, LaSiD Departamento de Farmácia, 59010-180Natal-RN, Brazil., Amaral-Machado L; UFRN, Laboratório de Sistemas Dispersos (LaSiD), Departamento de Farmácia59010-180, Natal-RN, Brazil.; UFRN, Programa de Pós-graduação em Ciências da Saúde, LaSiD, Departamento de Farmácia, 59010-180, Natal-RN, Brazil., Alencar EDN; UFRN, Laboratório de Sistemas Dispersos (LaSiD), Departamento de Farmácia59010-180, Natal-RN, Brazil.; UFRN, Programa de Pós-graduação em Nanotecnologia Farmacêutica, LaSiD Departamento de Farmácia, 59010-180Natal-RN, Brazil., Genre J; UFRN, Laboratório de Sistemas Dispersos (LaSiD), Departamento de Farmácia59010-180, Natal-RN, Brazil.; UFRN, Programa de Pós-graduação em Ciências da Saúde, LaSiD, Departamento de Farmácia, 59010-180, Natal-RN, Brazil., De Souza Araujo AA; Universidade Federal de SergipeDepartamento de Farmácia. 49100-000São Cristovão-SE, Brazil., Egito ESTD; Universidade Federal do Rio Grande do Norte (UFRN), Programa de Pós-graduação em Ciências Farmacêuticas, Departamento de Farmácia, 59010-180, Natal-RN, Brazil.; UFRN, Laboratório de Sistemas Dispersos (LaSiD), Departamento de Farmácia59010-180, Natal-RN, Brazil.; UFRN, Programa de Pós-graduação em Nanotecnologia Farmacêutica, LaSiD Departamento de Farmácia, 59010-180Natal-RN, Brazil.; UFRN, Programa de Pós-graduação em Ciências da Saúde, LaSiD, Departamento de Farmácia, 59010-180, Natal-RN, Brazil.
المصدر: Acta pharmaceutica (Zagreb, Croatia) [Acta Pharm] 2019 Mar 01; Vol. 69 (1), pp. 33-48.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Sciendo Country of Publication: Poland NLM ID: 9303678 Publication Model: Print Cited Medium: Internet ISSN: 1846-9558 (Electronic) Linking ISSN: 13300075 NLM ISO Abbreviation: Acta Pharm Subsets: MEDLINE
أسماء مطبوعة: Publication: Warsaw, Poland : Sciendo
Original Publication: Zagreb : Croatian Pharmaceutical Society, 1992-
مواضيع طبية MeSH: Emulsions/*chemistry , Nanoparticles/*chemistry , Oils/*chemistry, Administration, Oral ; Drug Delivery Systems/methods ; Oxidation-Reduction/drug effects ; Particle Size
مستخلص: The aim of this study was to develop, optimize, and characterize a stable therapeutic bullfrog oil based nanoemulsion for oral application using a rational experimental design approach. The optimized oral nanoemulsion contained 0.2 % sodium benzoate and 0.02 % propyl-paraben as preservatives; 0.1 % sucralose and 0.4 % acesulfam K as sweeteners and 0.1 % tutti-frutti as flavoring to mask the unpleasant organoleptic characteristics of bullfrog oil. The oral O/W-nanoemulsion showed the droplet size, PDI, zeta potential, and pH of 410 ± 8 nm, 0.20 ± 0.02, -38 ± 2.5 mV, and 6.43 ± 0.05, respectively. The optimized oral nanoemulsion showed a milky single-phase and optimal physical stability at 25 °C for 90 days. Indeed, higher oxidation induction time and lower formation of peroxides in the oral nanoemulsion were responsible for improving its stability. A therapeutic delivery system containing bullfrog oil for oral application was successfully developed and optimized with ideal thermo-oxidative stability.
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فهرسة مساهمة: Keywords: bullfrog oil; experimental design; nanoemulsion; oral application; therapeutic nanosystem; thermo-oxidative stability
المشرفين على المادة: 0 (Emulsions)
0 (Oils)
تواريخ الأحداث: Date Created: 20190702 Date Completed: 20191211 Latest Revision: 20230118
رمز التحديث: 20240628
DOI: 10.2478/acph-2019-0001
PMID: 31259715
قاعدة البيانات: MEDLINE
الوصف
تدمد:1846-9558
DOI:10.2478/acph-2019-0001