دورية أكاديمية
NAÏVE-POOLED PHARMACOKINETICS OF CEFTIOFUR CRYSTALLINE FREE ACID AFTER SINGLE INTRAMUSCULAR ADMINISTRATION IN SMOOTH DOGFISH ( MUSTELUS CANIS ).
| العنوان: | NAÏVE-POOLED PHARMACOKINETICS OF CEFTIOFUR CRYSTALLINE FREE ACID AFTER SINGLE INTRAMUSCULAR ADMINISTRATION IN SMOOTH DOGFISH ( MUSTELUS CANIS ). |
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| المؤلفون: | Fayette MA; Indianapolis Zoo, Indianapolis, IN 46222, USA, mfayette@indyzoo.com., Rose JB; Indianapolis Zoo, Indianapolis, IN 46222, USA., Hunter RP; One Medicine Consulting, Olathe, KS 66062, USA., Bowman MR; Indianapolis Zoo, Indianapolis, IN 46222, USA., Proudfoot JS; Indianapolis Zoo, Indianapolis, IN 46222, USA. |
| المصدر: | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians [J Zoo Wildl Med] 2019 Jun 13; Vol. 50 (2), pp. 466-469. Date of Electronic Publication: 2019 Jun 13. |
| نوع المنشور: | Clinical Trial, Veterinary; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association Of Zoo Veterinarians Country of Publication: United States NLM ID: 8915208 Publication Model: Electronic Cited Medium: Internet ISSN: 1042-7260 (Print) Linking ISSN: 10427260 NLM ISO Abbreviation: J Zoo Wildl Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Lawrence Ks : American Association Of Zoo Veterinarians Original Publication: Lawrence, Kan. : The Association, [1989- |
| مواضيع طبية MeSH: | Anti-Bacterial Agents/*pharmacokinetics , Cephalosporins/*pharmacokinetics , Sharks/*blood, Animals ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/blood ; Area Under Curve ; Cephalosporins/administration & dosage ; Cephalosporins/blood ; Injections, Intramuscular |
| مستخلص: | Pharmacokinetics study of ceftiofur crystalline free acid (CCFA) was conducted in 14 adult captive smooth dogfish ( Mustelus canis ). A single dose of CCFA at 6.6 mg/kg was administered intramuscularly. Blood samples were collected prior to treatment and at 1, 2, 6, 12, 24, 32, 48, 72, 96, 120, 144, and 168 hr posttreatment. Naïve pooling of data from four sharks was used to generate the average plasma drug concentration at each time point. After concluding the study, additional blood samples were opportunistically collected from five randomly selected sharks at 1,920 hr. Plasma ceftiofur and desfuroylceftiofur metabolite concentrations were determined using reversed-phase high performance liquid chromatography (HPLC). Pharmacokinetic analysis was performed using a noncompartmental technique. Peak plasma concentration ( C |
| فهرسة مساهمة: | Keywords: Ceftiofur crystalline free acid; Mustelus canis; elasmobranch; pharmacokinetics; smooth dogfish |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Cephalosporins) 83JL932I1C (ceftiofur) |
| تواريخ الأحداث: | Date Created: 20190702 Date Completed: 20190829 Latest Revision: 20190829 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1638/2018-0104 |
| PMID: | 31260216 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1042-7260 |
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| DOI: | 10.1638/2018-0104 |