دورية أكاديمية
Individualized atrophy scores predict dementia onset in familial frontotemporal lobar degeneration.
| العنوان: | Individualized atrophy scores predict dementia onset in familial frontotemporal lobar degeneration. |
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| المؤلفون: | Staffaroni AM; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco CA, USA University of California, San Francisco, San Francisco CA, USA., Cobigo Y; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco CA, USA University of California, San Francisco, San Francisco CA, USA., Goh SM; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco CA, USA University of California, San Francisco, San Francisco CA, USA., Kornak J; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco CA, USA Department of Neurology, Memory and Aging Center., Bajorek L; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco CA, USA University of California, San Francisco, San Francisco CA, USA., Chiang K; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco CA, USA University of California, San Francisco, San Francisco CA, USA., Appleby B; Department of Neurology, Case Western Reserve University, Cleveland, OH, USA University of California, San Francisco, San Francisco CA, USA., Bove J; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA Department of Epidemiology and Biostatistics., Bordelon Y; Department of Neurology, University of California, Los Angeles, Los Angeles, CA, USA Case Western Reserve University, Cleveland, OH, USA., Brannelly P; Tau Consortium, Rainwater Charitable Foundation, Fort Worth, TX, USA Department of Neurology., Brushaber D; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA University of Pennsylvania, Philadelphia, PA, USA., Caso C; Department of Neurology, University of Washington, Seattle, WA, USA Perelman School of Medicine, Department of Neurology., Coppola G; Department of Neurology, University of California, Los Angeles, Los Angeles, CA, USA Case Western Reserve University, Cleveland, OH, USA.; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA University of California, Los Angeles, Los Angeles, CA, USA., Dever R; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco CA, USA University of California, San Francisco, San Francisco CA, USA., Dheel C; Department of Neurology, Mayo Clinic, Rochester, MN, USA Department of Neurology., Dickerson BC; Department of Neurology, Frontotemporal Disorders Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA Tau Consortium, Rainwater Charitable Foundation, Fort Worth, TX, USA., Dickinson S; Association for Frontotemporal Degeneration, Radnor, PA, USA Mayo Clinic, Rochester, MN, USA., Dominguez S; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA Department of Epidemiology and Biostatistics., Domoto-Reilly K; Department of Neurology, University of Washington, Seattle, WA, USA Perelman School of Medicine, Department of Neurology., Faber K; National Cell Repository for Alzheimer's Disease (NCRAD), Indiana University, Indianapolis, IN, USA National Cell Repository for Alzheimer's Disease (NCRAD), Indiana University, Indianapolis, IN, USA., Ferrall J; Department of Neurology, University of North Carolina, Chapel Hill, NC, USA University of Washington, Seattle, WA, USA., Fields JA; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA., Fishman A; Department of Psychiatry, School of Medicine, Johns Hopkins University, Baltimore, MD, USA School of Medicine, Department of Psychiatry., Fong J; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco CA, USA University of California, San Francisco, San Francisco CA, USA., Foroud T; National Cell Repository for Alzheimer's Disease (NCRAD), Indiana University, Indianapolis, IN, USA National Cell Repository for Alzheimer's Disease (NCRAD), Indiana University, Indianapolis, IN, USA., Forsberg LK; Department of Neurology, Mayo Clinic, Rochester, MN, USA Department of Neurology., Gavrilova R; Department of Neurology, Mayo Clinic, Rochester, MN, USA Department of Neurology., Gearhart D; Department of Neurology, Mayo Clinic, Rochester, MN, USA Department of Neurology., Ghazanfari B; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada University of California, Los Angeles, Los Angeles, CA, USA.; Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada., Ghoshal N; Departments of Neurology and Psychiatry, Washington University School of Medicine, Washington University, St. Louis, MO, USA Mayo Clinic, Rochester, MN, USA., Goldman J; Department of Neurology, Columbia University, New York, NY, USA Department of Neurology.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA Department of Neurology, Frontotemporal Disorders Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Graff-Radford J; Department of Neurology, Mayo Clinic, Rochester, MN, USA Department of Neurology., Graff-Radford N; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA Association for Frontotemporal Degeneration, Radnor, PA, USA., Grant I; Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA National Cell Repository for Alzheimer's Disease (NCRAD), Indiana University, Indianapolis, IN, USA., Grossman M; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA Department of Epidemiology and Biostatistics., Haley D; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA Association for Frontotemporal Degeneration, Radnor, PA, USA., Heuer HW; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco CA, USA University of California, San Francisco, San Francisco CA, USA., Hsiung GY; Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada University of North Carolina, Chapel Hill, NC, USA., Huey ED; Department of Neurology, Columbia University, New York, NY, USA Department of Neurology.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA Department of Neurology, Frontotemporal Disorders Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Irwin DJ; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA Department of Epidemiology and Biostatistics., Jones DT; Department of Neurology, Mayo Clinic, Rochester, MN, USA Department of Neurology., Jones L; Department of Radiology, Washington University School of Medicine, Washington University, St. Louis, MO, USA Johns Hopkins University, Baltimore, MD, USA., Kantarci K; Department of Radiology, Mayo Clinic, Rochester, MN, USA Department of Radiology., Karydas A; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco CA, USA University of California, San Francisco, San Francisco CA, USA., Kaufer DI; Department of Neurology, University of North Carolina, Chapel Hill, NC, USA University of Washington, Seattle, WA, USA., Kerwin DR; Department of Neurology and Neurotherapeutics, Center for Alzheimer's and Neurodegenerative Diseases, The University of Texas, Southwestern Medical Center at Dallas, Dallas, TX, USA Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto.; Department of Internal Medicine, The University of Texas, Southwestern Medical Center at Dallas, Dallas, TX, USA Division of Neurology, Department of Medicine, University of Toronto., Knopman DS; Department of Neurology, Mayo Clinic, Rochester, MN, USA Department of Neurology., Kraft R; Department of Neurology, Mayo Clinic, Rochester, MN, USA Department of Neurology., Kramer JH; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco CA, USA University of California, San Francisco, San Francisco CA, USA., Kremers WK; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA University of Pennsylvania, Philadelphia, PA, USA., Kukull WA; National Alzheimer Coordinating Center (NACC), University of Washington, Seattle, WA, USA Washington University, St. Louis, MO, USA., Litvan I; Department of Neurosciences, Parkinson and Other Movement Disorders Center, University of California, San Diego, San Diego, CA, USA Department of Neurosciences, Parkinson and Other Movement Disorders Center., Ljubenkov PA; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco CA, USA University of California, San Francisco, San Francisco CA, USA., Lucente D; Department of Neurology, Frontotemporal Disorders Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA Tau Consortium, Rainwater Charitable Foundation, Fort Worth, TX, USA., Lungu C; National Institute of Neurological Disorders and Stroke (NINDS), Bethesda, MD, USA Columbia University, New York, NY, USA., Mackenzie IR; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Maldonado M; Department of Neurology, University of California, Los Angeles, Los Angeles, CA, USA Case Western Reserve University, Cleveland, OH, USA., Manoochehri M; Department of Neurology, Columbia University, New York, NY, USA Department of Neurology., McGinnis SM; Department of Neurology, Frontotemporal Disorders Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA Tau Consortium, Rainwater Charitable Foundation, Fort Worth, TX, USA., McKinley E; Department of Neurology, Alzheimer's Disease Center, University of Alabama at Birmingham, Birmingham, AL, USA Columbia University, New York, NY, USA., Mendez MF; Department of Neurology, University of California, Los Angeles, Los Angeles, CA, USA Case Western Reserve University, Cleveland, OH, USA.; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA University of California, Los Angeles, Los Angeles, CA, USA., Miller BL; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco CA, USA University of California, San Francisco, San Francisco CA, USA., Multani N; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada University of California, Los Angeles, Los Angeles, CA, USA.; Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada., Onyike C; Department of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University, Baltimore, MD, USA Department of Geriatric Psychiatry and Neuropsychiatry., Padmanabhan J; Department of Neurology, Frontotemporal Disorders Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA Tau Consortium, Rainwater Charitable Foundation, Fort Worth, TX, USA., Pantelyat A; Department of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA Mayo Clinic, Jacksonville, FL, USA., Pearlman R; Bluefield Project, San Francisco, CA, USA Bluefield Project, San Francisco, CA, USA., Petrucelli L; Department of Neurosciences, Mayo Clinic, Jacksonville, FL, USA Northwestern University, Chicago, IL, USA., Potter M; National Cell Repository for Alzheimer's Disease (NCRAD), Indiana University, Indianapolis, IN, USA National Cell Repository for Alzheimer's Disease (NCRAD), Indiana University, Indianapolis, IN, USA., Rademakers R; Department of Neurosciences, Mayo Clinic, Jacksonville, FL, USA Northwestern University, Chicago, IL, USA., Ramos EM; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA University of California, Los Angeles, Los Angeles, CA, USA., Rankin KP; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco CA, USA University of California, San Francisco, San Francisco CA, USA., Rascovsky K; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA Department of Epidemiology and Biostatistics., Roberson ED; Department of Neurology, Alzheimer's Disease Center, University of Alabama at Birmingham, Birmingham, AL, USA Columbia University, New York, NY, USA., Rogalski E; Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA Feinberg School of Medicine, Department of Psychiatry and Behavioral Sciences., Sengdy P; Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada University of North Carolina, Chapel Hill, NC, USA., Shaw LM; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA University of British Columbia, Vancouver, British Columbia, Canada., Syrjanen J; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA University of Pennsylvania, Philadelphia, PA, USA., Tartaglia MC; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada University of California, Los Angeles, Los Angeles, CA, USA.; Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada., Tatton N; Association for Frontotemporal Degeneration, Radnor, PA, USA Mayo Clinic, Rochester, MN, USA., Taylor J; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco CA, USA University of California, San Francisco, San Francisco CA, USA., Toga A; Departments of Ophthalmology, Neurology, Psychiatry and the Behavioral Sciences, Radiology and Engineering, Laboratory of Neuroimaging (LONI), USC, Los Angeles, CA, USA Laboratory of Neuroimaging (LONI), Departments of Ophthalmology, Neurology, Psychiatry and the Behavioral Sciences, Radiology and Engineering., Trojanowski JQ; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA University of British Columbia, Vancouver, British Columbia, Canada., Weintraub S; Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA National Cell Repository for Alzheimer's Disease (NCRAD), Indiana University, Indianapolis, IN, USA., Wang P; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco CA, USA University of California, San Francisco, San Francisco CA, USA., Wong B; Department of Neurology, Frontotemporal Disorders Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA Tau Consortium, Rainwater Charitable Foundation, Fort Worth, TX, USA., Wszolek Z; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA Association for Frontotemporal Degeneration, Radnor, PA, USA., Boxer AL; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco CA, USA University of California, San Francisco, San Francisco CA, USA., Boeve BF; Department of Neurology, Mayo Clinic, Rochester, MN, USA Department of Neurology., Rosen HJ; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco CA, USA University of California, San Francisco, San Francisco CA, USA. |
| مؤلفون مشاركون: | ARTFL/LEFFTDS consortium |
| المصدر: | Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2020 Jan; Vol. 16 (1), pp. 37-48. Date of Electronic Publication: 2020 Jan 06. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2020- : Hoboken, NJ : John Wiley & Sons, Ltd. Original Publication: Orlando, FL : Elsevier, Inc. |
| مواضيع طبية MeSH: | Frontotemporal Dementia*/diagnostic imaging , Frontotemporal Dementia*/genetics , Genetic Predisposition to Disease*, Atrophy/*pathology , Mutation/*genetics , Neuropsychological Tests/*statistics & numerical data, Brain/pathology ; C9orf72 Protein/genetics ; Female ; Humans ; Image Processing, Computer-Assisted/statistics & numerical data ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Progranulins/genetics ; tau Proteins/genetics |
| مستخلص: | Introduction: Some models of therapy for neurodegenerative diseases envision starting treatment before symptoms develop. Demonstrating that such treatments are effective requires accurate knowledge of when symptoms would have started without treatment. Familial frontotemporal lobar degeneration offers a unique opportunity to develop predictors of symptom onset. Methods: We created dementia risk scores in 268 familial frontotemporal lobar degeneration family members by entering covariate-adjusted standardized estimates of brain atrophy into a logistic regression to classify asymptomatic versus demented participants. The score's predictive value was tested in a separate group who were followed up longitudinally (stable vs. converted to dementia) using Cox proportional regressions with dementia risk score as the predictor. Results: Cross-validated logistic regression achieved good separation of asymptomatic versus demented (accuracy = 90%, SE = 0.06). Atrophy scores predicted conversion from asymptomatic or mildly/questionably symptomatic to dementia (HR = 1.51, 95% CI: [1.16,1.98]). Discussion: Individualized quantification of baseline brain atrophy is a promising predictor of progression in asymptomatic familial frontotemporal lobar degeneration mutation carriers. (© 2019 The Authors. Alzheimer's & Dementia published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association.) |
| References: | Eur J Neurol. 2015 May;22(5):745-52. (PMID: 25683866) Neuroimage. 2006 Jul 1;31(3):968-80. (PMID: 16530430) Hum Brain Mapp. 2015 Nov;36(11):4421-37. (PMID: 26260856) Lancet Neurol. 2015 Mar;14(3):253-62. (PMID: 25662776) Brain. 2008 Nov;131(Pt 11):2957-68. (PMID: 18829698) Am J Neurodegener Dis. 2014 Mar 28;3(1):1-18. (PMID: 24753999) J Neurochem. 2016 Aug;138 Suppl 1:211-21. (PMID: 27306957) Neurology. 2005 Sep 13;65(5):719-25. (PMID: 16157905) Neurology. 1997 Sep;49(3):786-94. (PMID: 9305341) Clin Genet. 2004 Apr;65(4):267-77. (PMID: 15025718) IEEE Trans Med Imaging. 1998 Feb;17(1):87-97. (PMID: 9617910) Front Neurosci. 2013 Feb 05;6:197. (PMID: 23386806) Neurology. 2014 Jul 15;83(3):253-60. (PMID: 24928124) Neurology. 2018 Jan 23;90(4):e282-e290. (PMID: 29282337) J Neurochem. 2016 Aug;138 Suppl 1:6-31. (PMID: 27144467) JAMA Neurol. 2016 Apr;73(4):431-8. (PMID: 26902171) Neuroimage Clin. 2018 Jul 17;20:188-196. (PMID: 30094168) Nat Rev Neurol. 2017 Feb;13(2):74-76. (PMID: 28084326) N Engl J Med. 2012 Aug 30;367(9):795-804. (PMID: 22784036) Alzheimers Dement. 2013 Mar;9(2):123-131.e1. (PMID: 23411394) Mol Neurodegener. 2012 Aug 14;7:39. (PMID: 22892055) Alzheimer Dis Assoc Disord. 2018 Jan-Mar;32(1):10-17. (PMID: 29240561) Radiology. 2009 Apr;251(1):195-205. (PMID: 19201945) Int Rev Psychiatry. 2013 Apr;25(2):221-9. (PMID: 23611351) Neuroimage. 2007 Oct 15;38(1):95-113. (PMID: 17761438) Lancet Neurol. 2010 Jan;9(1):119-28. (PMID: 20083042) Brain. 2007 May;130(Pt 5):1360-74. (PMID: 17439980) Prog Neurobiol. 2011 Dec;95(4):629-35. (PMID: 21930184) J Neuropathol Exp Neurol. 2018 May 1;77(5):405-412. (PMID: 29584904) Neurology. 2017 Sep 19;89(12):1256-1264. (PMID: 28855404) Clin Investig (Lond). 2012 Oct 1;2(10):975-984. (PMID: 23139856) Neurology. 2016 May 3;86(18):1736-43. (PMID: 27037234) Nature. 2017 Jul 12;547(7662):153-155. (PMID: 28703214) Radiology. 2011 Jun;259(3):834-43. (PMID: 21471273) |
| معلومات مُعتمدة: | K23 AG061253 United States AG NIA NIH HHS; K24 AG045333 United States AG NIA NIH HHS; U24 AG021886 United States AG NIA NIH HHS; U24 AG072122 United States AG NIA NIH HHS; P01 AG019724 United States AG NIA NIH HHS; R01 AG032306 United States AG NIA NIH HHS; P01 AG066597 United States AG NIA NIH HHS; U01 AG045390 United States AG NIA NIH HHS; U54 NS092089 United States NS NINDS NIH HHS; R01 AG055121 United States AG NIA NIH HHS; P30 AG013854 United States AG NIA NIH HHS; P30 AG062421 United States AG NIA NIH HHS; P50 AG008702 United States AG NIA NIH HHS; U19 AG063911 United States AG NIA NIH HHS; U01 AG016976 United States AG NIA NIH HHS; T32 AG023481 United States AG NIA NIH HHS; K23 AG059891 United States AG NIA NIH HHS |
| فهرسة مساهمة: | Keywords: Frontotemporal dementia; Genetics; Magnetic resonance imaging (MRI); TDP-43; Tau |
| المشرفين على المادة: | 0 (C9orf72 Protein) 0 (C9orf72 protein, human) 0 (GRN protein, human) 0 (MAPT protein, human) 0 (Progranulins) 0 (tau Proteins) |
| تواريخ الأحداث: | Date Created: 20190706 Date Completed: 20201030 Latest Revision: 20240302 |
| رمز التحديث: | 20240302 |
| مُعرف محوري في PubMed: | PMC6938544 |
| DOI: | 10.1016/j.jalz.2019.04.007 |
| PMID: | 31272932 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1552-5279 |
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| DOI: | 10.1016/j.jalz.2019.04.007 |