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Diagnosis of Mixed Adenoneuroendocrine Carcinoma (MANEC) after Neoadjuvant Chemotherapy for Pancreatic and Gastric Adenocarcinoma: Two Case Reports and a Review of the Literature.

التفاصيل البيبلوغرافية
العنوان: Diagnosis of Mixed Adenoneuroendocrine Carcinoma (MANEC) after Neoadjuvant Chemotherapy for Pancreatic and Gastric Adenocarcinoma: Two Case Reports and a Review of the Literature.
المؤلفون: Oneda E; Department of Clinical Oncology, Fondazione Poliambulanza, Brescia, Italy., Liserre B; Department of Pathology, Fondazione Poliambulanza, Brescia, Italy., Bianchi D; Department of Pathology, Fondazione Poliambulanza, Brescia, Italy., Rota L; Department of Clinical Oncology, Fondazione Poliambulanza, Brescia, Italy., Savelli G; Department of Nuclear Medicine, Fondazione Poliambulanza, Brescia, Italy., Zorzi F; Department of Pathology, Fondazione Poliambulanza, Brescia, Italy., Zaniboni A; Department of Clinical Oncology, Fondazione Poliambulanza, Brescia, Italy.
المصدر: Case reports in oncology [Case Rep Oncol] 2019 Jun 13; Vol. 12 (2), pp. 434-442. Date of Electronic Publication: 2019 Jun 13 (Print Publication: 2019).
نوع المنشور: Case Reports
اللغة: English
بيانات الدورية: Publisher: Karger Country of Publication: Switzerland NLM ID: 101517601 Publication Model: eCollection Cited Medium: Print ISSN: 1662-6575 (Print) Linking ISSN: 16626575 NLM ISO Abbreviation: Case Rep Oncol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel : Karger
مستخلص: Mixed adenoneuroendocrine carcinoma (MANEC) is a rare tumor of the gastrointestinal tract involving both epithelial and neuroendocrine (NE) components, each of which represents at least 30% of the tumor. Because of the low frequency of this histotype, only a few cases have been described. In this report we discuss two cases treated with neoadjuvant chemotherapy: a pancreatic adenocarcinoma and a gastric adenocarcinoma. The histopathological specimens examined after surgery showed an additional NE component with a possible indication of the MANEC histotype. We hypothesize two possible explanations: tumor NE cells are more chemo-resistant than adenocarcinoma cells, and cytotoxic injury induces NE differentiation in tumor cells. The clinical significance and prognostic value of endocrine differentiation, however, remain controversial issues.
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فهرسة مساهمة: Keywords: Mixed adenoneuroendocrine carcinoma; Neoadjuvant chemotherapy; Neuroendocrine differentiation
تواريخ الأحداث: Date Created: 20190706 Latest Revision: 20200930
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6600038
DOI: 10.1159/000501200
PMID: 31275134
قاعدة البيانات: MEDLINE
الوصف
تدمد:1662-6575
DOI:10.1159/000501200