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Prevalence of familial hypercholesterolemia in premature coronary artery disease patients admitted to a tertiary care hospital in North India.

التفاصيل البيبلوغرافية
العنوان: Prevalence of familial hypercholesterolemia in premature coronary artery disease patients admitted to a tertiary care hospital in North India.
المؤلفون: Sawhney JPS; Dharma Vira Heart Center, Sir Ganga Ram Hospital, New Delhi 110060, India. Electronic address: jpssawhney@yahoo.com., Prasad SR; Dharma Vira Heart Center, Sir Ganga Ram Hospital, New Delhi 110060, India. Electronic address: shashiranjanprasad0@gmail.com., Sharma M; Dharma Vira Heart Center, Sir Ganga Ram Hospital, New Delhi 110060, India. Electronic address: doctormanishksharma@gmail.com., Madan K; Dharma Vira Heart Center, Sir Ganga Ram Hospital, New Delhi 110060, India. Electronic address: kushalmadan@gmail.com., Mohanty A; Dharma Vira Heart Center, Sir Ganga Ram Hospital, New Delhi 110060, India. Electronic address: arunmohanty25@hotmail.com., Passey R; Dharma Vira Heart Center, Sir Ganga Ram Hospital, New Delhi 110060, India. Electronic address: drrpassey@yahoo.com., Mehta A; Dharma Vira Heart Center, Sir Ganga Ram Hospital, New Delhi 110060, India. Electronic address: drashwanimehta@gmail.com., Kandpal B; Dharma Vira Heart Center, Sir Ganga Ram Hospital, New Delhi 110060, India. Electronic address: bhuwaneshk@yahoo.co.in., Makhija A; Dharma Vira Heart Center, Sir Ganga Ram Hospital, New Delhi 110060, India. Electronic address: amanmakhija@gmail.com., Jain R; Dharma Vira Heart Center, Sir Ganga Ram Hospital, New Delhi 110060, India. Electronic address: jainsaniya@yahoo.com., Mantri RR; Dharma Vira Heart Center, Sir Ganga Ram Hospital, New Delhi 110060, India. Electronic address: drrrmantri@hotmail.com., Vivek BS; Dharma Vira Heart Center, Sir Ganga Ram Hospital, New Delhi 110060, India. Electronic address: bsvivekdr@gmail.com., Manchanda SC; Dharma Vira Heart Center, Sir Ganga Ram Hospital, New Delhi 110060, India. Electronic address: doctormanchanda@yahoo.com., Verma IC; Institute of Medical Genetics and Genomics, Sir Gangaram Hospital, New Delhi 110060, India. Electronic address: icverma@gmail.com.
المصدر: Indian heart journal [Indian Heart J] 2019 Mar - Apr; Vol. 71 (2), pp. 118-122. Date of Electronic Publication: 2019 Jan 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: India NLM ID: 0374675 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-3763 (Electronic) Linking ISSN: 00194832 NLM ISO Abbreviation: Indian Heart J Subsets: MEDLINE
أسماء مطبوعة: Publication: 2012- : Amsterdam : Elsevier
Original Publication: Calcutta : Cardiological Society of India
مواضيع طبية MeSH: Coronary Artery Disease/*epidemiology , Hyperlipoproteinemia Type II/*epidemiology, Adult ; Female ; Humans ; India/epidemiology ; Male ; Middle Aged ; Prevalence ; Tertiary Care Centers
مستخلص: Aims: The prevalence of premature coronary artery disease (CAD) in India is two to three times more than other ethnic groups. Untreated heterozygous familial hypercholesterolemia (FH) is one of the important causes for premature CAD. As the age advances, these patients without treatment have 100 times increased risk of cardiovascular (CV) mortality resulting from myocardial infarction (MI). Recent evidence suggests that one in 250 individuals may be affected by FH (nearly 40 million people globally). It is indicated that the true global prevalence of FH is underestimated. The true prevalence of FH in India remains unknown.
Methods: A total of 635 patients with premature CAD were assessed for FH using the Dutch Lipid Clinical Network (DLCN) criteria. Based on scores, patients were diagnosed as definite, probable, possible, or no FH. Other CV risk factors known to cause CAD such as smoking, diabetes mellitus, and hypertension were also recorded.
Results: Of total 635 patients, 25 (4%) were diagnosed as definite, 70 (11%) as probable, 238 (37%) as possible, and 302 (48%) without FH, suggesting the prevalence of potential (definite + probable) FH of about 15% in the North Indian population. FH is more common in younger patients, and they have lesser incidence of common CV risk factors such as diabetes, hypertension, and smoking than the younger MI patients without FH (26.32% vs.42.59%; 17.89% vs.29.44%; 22.11% vs.40.74%).
Conclusion: FH prevalence is high among patients with premature CAD admitted to a cardiac unit. To detect patients with FH, routine screening with simple criteria such as family history of premature CAD combined with hypercholesterolemia, and a DLCN criteria score >5 may be effectively used.
(Copyright © 2019 Cardiological Society of India. Published by Elsevier B.V. All rights reserved.)
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فهرسة مساهمة: Keywords: Arcus cornealis; Correction factor; Dutch Lipid Clinic Network Criteria; Familial hypercholesterolemia; Premature coronary artery disease
تواريخ الأحداث: Date Created: 20190709 Date Completed: 20200113 Latest Revision: 20200301
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC6620422
DOI: 10.1016/j.ihj.2018.12.004
PMID: 31280822
قاعدة البيانات: MEDLINE
الوصف
تدمد:2213-3763
DOI:10.1016/j.ihj.2018.12.004