دورية أكاديمية
Projected Number of People With Onchocerciasis-Loiasis Coinfection in Africa, 1995 to 2025.
| العنوان: | Projected Number of People With Onchocerciasis-Loiasis Coinfection in Africa, 1995 to 2025. |
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| المؤلفون: | Vinkeles Melchers NVS; Department of Public Health, Erasmus MC, University Medical Center Rotterdam, The Netherlands., Coffeng LE; Department of Public Health, Erasmus MC, University Medical Center Rotterdam, The Netherlands., Boussinesq M; Unité Mixte Internationale 233 TransVIHMI, Institut de Recherche pour le Développement (IRD), INSERM U1175, University of Montpellier, Montpellier, France., Pedrique B; Research & Development Department, Drugs for Neglected Diseases initiative, and, Geneva, Switzerland., Pion SDS; Unité Mixte Internationale 233 TransVIHMI, Institut de Recherche pour le Développement (IRD), INSERM U1175, University of Montpellier, Montpellier, France., Tekle AH; Preventive Chemotherapy and Transmission Control Unit, Control of Neglected Tropical Diseases Department, World Health Organization, Geneva, Switzerland., Zouré HGM; Expanded Special Project for Elimination of Neglected Tropical Diseases (ESPEN), World Health Organization, Regional Office for Africa, Cité du Djoué, Brazzaville, Republic of Congo., Wanji S; Parasites and Vectors Research Unit, Department of Microbiology and Parasitology, University of Buea, Cameroon., Remme JH; Ornex, France., Stolk WA; Department of Public Health, Erasmus MC, University Medical Center Rotterdam, The Netherlands. |
| المصدر: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2020 May 23; Vol. 70 (11), pp. 2281-2289. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 9203213 Publication Model: Print Cited Medium: Internet ISSN: 1537-6591 (Electronic) Linking ISSN: 10584838 NLM ISO Abbreviation: Clin Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Oxford : Oxford University Press Original Publication: Chicago, IL : The University of Chicago Press, c1992- |
| مواضيع طبية MeSH: | Coinfection*/epidemiology , Loiasis*/complications , Loiasis*/epidemiology , Onchocerciasis*/complications , Onchocerciasis*/drug therapy , Onchocerciasis*/epidemiology, Africa/epidemiology ; Animals ; Humans ; Ivermectin/therapeutic use ; Loa |
| مستخلص: | Background: Onchocerciasis elimination through mass drug administration (MDA) is hampered by coendemicity of Loa loa, as people with high L. loa microfilariae (mf) density can develop serious adverse events (SAEs) after ivermectin treatment. We assessed the geographical overlap of onchocerciasis and loiasis prevalence and estimated the number of coinfected individuals at risk of post-ivermectin SAEs in West and Central Africa from 1995 to 2025. Methods: Focusing on regions with suspected loiasis transmission in 14 countries, we overlaid precontrol maps of loiasis and onchocerciasis prevalence to calculate precontrol prevalence of coinfection by 5 km2 × 5 km2 pixel, distinguishing different categories of L. loa mf intensity. Using statistical and mathematical models, we predicted prevalence of both infections and coinfection for 2015 and 2025, accounting for the impact of MDA with ivermectin. Results: The number of people infected with onchocerciasis was predicted to decline from almost 19 million in 1995 to 4 million in 2025. Of these, 137 000 people were estimated to also have L. loa hypermicrofilaremia (≥20 000 L. loa mf/mL) in 1995, declining to 31 000 in 2025. In 2025, 92.8% of coinfected cases with loiasis hypermicrofilaremia are predicted to live in hypoendemic areas currently not targeted for MDA. Conclusions: Loiasis coinfection is a major concern for onchocerciasis elimination in Africa. We predict that under current strategies, at least 31 000 coinfected people still require treatment for onchocerciasis in 2025 while being at risk of SAEs, justifying continued efforts in research and development for safer drugs and control strategies. (© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America.) |
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| معلومات مُعتمدة: | 001 International WHO_ World Health Organization |
| فهرسة مساهمة: | Keywords: Loa loa; ONCHOSIM; mass drug administration; onchocerciasis; serious adverse events |
| المشرفين على المادة: | 70288-86-7 (Ivermectin) |
| تواريخ الأحداث: | Date Created: 20190716 Date Completed: 20210106 Latest Revision: 20220129 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC7245158 |
| DOI: | 10.1093/cid/ciz647 |
| PMID: | 31304961 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1537-6591 |
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| DOI: | 10.1093/cid/ciz647 |