دورية أكاديمية
Malacoplakia of the skin: overview of a rare clinical entity.
| العنوان: | Malacoplakia of the skin: overview of a rare clinical entity. |
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| المؤلفون: | Kyriakou G; Department of Dermatology, University General Hospital of Patras. geo_kyr@yahoo.gr., Gialeli E, Vryzaki E, Koumoundourou D, Glentis A, Georgiou S |
| المصدر: | Dermatology online journal [Dermatol Online J] 2019 Jun 15; Vol. 25 (6). Date of Electronic Publication: 2019 Jun 15. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: University of California, Davis Country of Publication: United States NLM ID: 9610776 Publication Model: Electronic Cited Medium: Internet ISSN: 1087-2108 (Electronic) Linking ISSN: 10872108 NLM ISO Abbreviation: Dermatol Online J Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Davis, Calif.] : University of California, Davis, c1995- |
| مواضيع طبية MeSH: | Macrophages/*pathology , Malacoplakia/*pathology , Skin Diseases, Bacterial/*pathology, Anti-Bacterial Agents/therapeutic use ; Dermatologic Surgical Procedures ; Granuloma/pathology ; Humans ; Macrophages/immunology ; Malacoplakia/diagnosis ; Malacoplakia/immunology ; Malacoplakia/therapy ; Phagocyte Bactericidal Dysfunction/immunology ; Skin Diseases, Bacterial/diagnosis ; Skin Diseases, Bacterial/immunology ; Skin Diseases, Bacterial/therapy |
| مستخلص: | Background: Malacoplakia is a rare acquired, infection-related granulomatous disorder, that may affect many systems, but typically occurs in the urinary tract. Cutaneous involvement is less prevalent, and most commonly presents with a perianal or genital region localization. Cutaneous malacoplakia is believed to be caused by an acquired bactericidal defect of macrophages in the setting of chronic infections and immunocompromised states. A diagnosis of cutaneous malacoplakia should be considered when encountering non-specific granulomatous lesions that are refractory to treatment. Histologic findings are marked by the presence of foamy macrophages containing the pathognomonic Michaelis-Gutman bodies. Objectives: The aim of this review is to discuss the current perspectives on the pathophysiology, clinical features, diagnosis, and treatment of this disease. We would also like to emphasize that the integration of clinical information, microscopic findings, and exclusion of other cutaneous granulomatous processes is necessary to accurately diagnose this exceedingly rare disease and provide opportunity for therapeutic intervention. Patients/methods: Data for this work were collected from the published literature and textbooks. Results: Combined surgical excision and protracted antibiotic courses appear to have the highest success rate. Antibiotics should be culture specific, but drugs that easily permeate the macrophages appear to be the best choice. |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) |
| تواريخ الأحداث: | Date Created: 20190723 Date Completed: 20200122 Latest Revision: 20200122 |
| رمز التحديث: | 20221213 |
| PMID: | 31329385 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1087-2108 |
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