دورية أكاديمية
أعرض في EDS

Reassessment of the prevalence of soil-transmitted helminth infections in Sri Lanka to enable a more focused control programme: a cross-sectional national school survey with spatial modelling.

التفاصيل البيبلوغرافية
العنوان: Reassessment of the prevalence of soil-transmitted helminth infections in Sri Lanka to enable a more focused control programme: a cross-sectional national school survey with spatial modelling.
المؤلفون: Ediriweera DS; Centre for Health Informatics, Biostatistics and Epidemiology, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka. Electronic address: dileepa@kln.ac.lk., Gunawardena S; Department of Parasitology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka., Gunawardena NK; Department of Parasitology, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka., Iddawela D; Department of Parasitology, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka., Kannathasan S; Department of Parasitology, Faculty of Medicine, University of Jaffna, Jaffna, Sri Lanka., Murugananthan A; Department of Parasitology, Faculty of Medicine, University of Jaffna, Jaffna, Sri Lanka., Yahathugoda C; Department of Parasitology, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka., Pathmeswaran A; Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka., Diggle PJ; Centre for Health Informatics, Computing and Statistics, University of Lancaster, Lancaster, UK., de Silva N; Department of Parasitology, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
المصدر: The Lancet. Global health [Lancet Glob Health] 2019 Sep; Vol. 7 (9), pp. e1237-e1246. Date of Electronic Publication: 2019 Jul 19.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101613665 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2214-109X (Electronic) Linking ISSN: 2214109X NLM ISO Abbreviation: Lancet Glob Health Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [England] : Elsevier Ltd. 2013-
مواضيع طبية MeSH: Helminthiasis/*epidemiology , Helminthiasis/*transmission , Soil/*parasitology, Animals ; Child ; Child, Preschool ; Cross-Sectional Studies ; Feces/parasitology ; Female ; Helminthiasis/prevention & control ; Helminths/isolation & purification ; Humans ; Male ; Prevalence ; Schools ; Spatial Analysis ; Sri Lanka/epidemiology
مستخلص: Background: In Sri Lanka, deworming programmes for soil-transmitted helminth infections became an integral part of school health in the 1960s, whereas routine antenatal deworming with mebendazole started in the 1980s. A 2003 national soil-transmitted helminth survey done among schoolchildren found an overall prevalence of 6·9%. In our study, we aimed to reassess the national prevalence of soil-transmitted helminth infections to enable implementation of a more focused control programme that targets smaller administrative areas at risk of continued transmission.
Methods: We did a cross-sectional, school-based, national survey using multistage stratified cluster sampling, covering all nine provinces as well as populations at high risk of soil-transmitted helminth infections living in urban slums and in plantation-sector communities. Our study population was children aged 5-7 years attending state schools. Faecal samples were collected and analysed with duplicate modified Kato-Katz smears. We modelled the risk of soil-transmitted helminth infection using generalised linear mixed-effects models, and we developed prevalence maps to enable informed decision making at the smallest health administrative level in the country.
Findings: Between Jan 23 and May 9, 2017, we recruited 5946 children from 130 schools; 4276 (71·9%) children provided a faecal sample for examination. National prevalence of soil-transmitted helminth infection was 0·97% (95% CI 0·63-1·48) among primary schoolchildren. Prevalence in the high-risk communities surveyed was higher than national prevalence: 2·73% (0·75-6·87) in urban slum communities and 9·02% (4·29-18·0) in plantation sector communities. Our prevalence maps showed that the lowest-level health administrative regions could be categorised into low risk (prevalence <1%), high risk (prevalence >10%), or intermediate risk (1-10%) areas.
Interpretation: Our survey findings indicate that the national prevalence of soil-transmitted helminth infection has continued to decline in Sri Lanka. On the basis of WHO guidelines, we recommend discontinuation of routine deworming in low-risk areas, continuation of annual deworming in high-risk areas, and deworming once every 2 years in intermediate-risk areas, for at least 4 years.
Funding: Task Force for Global Health and WHO.
(Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved.)
التعليقات: Comment in: Lancet Glob Health. 2019 Sep;7(9):e1156-e1157. (PMID: 31331810)
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المشرفين على المادة: 0 (Soil)
تواريخ الأحداث: Date Created: 20190724 Date Completed: 20200526 Latest Revision: 20231013
رمز التحديث: 20231013
مُعرف محوري في PubMed: PMC6688098
DOI: 10.1016/S2214-109X(19)30253-0
PMID: 31331809
قاعدة البيانات: MEDLINE
الوصف
تدمد:2214-109X
DOI:10.1016/S2214-109X(19)30253-0