دورية أكاديمية
Balancing Extrasynaptic Excitation and Synaptic Inhibition within Olfactory Bulb Glomeruli.
| العنوان: | Balancing Extrasynaptic Excitation and Synaptic Inhibition within Olfactory Bulb Glomeruli. |
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| المؤلفون: | Gire DH; Department of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, CO 80045.; Neuroscience Graduate Program, University of Colorado School of Medicine, Aurora, CO 80045., Zak JD; Department of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, CO 80045.; Neuroscience Graduate Program, University of Colorado School of Medicine, Aurora, CO 80045., Bourne JN; Department of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, CO 80045., Goodson NB; Neuroscience Graduate Program, University of Colorado School of Medicine, Aurora, CO 80045., Schoppa NE; Department of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, CO 80045 nathan.schoppa@ucdenver.edu. |
| المصدر: | ENeuro [eNeuro] 2019 Aug 07; Vol. 6 (4). Date of Electronic Publication: 2019 Aug 07 (Print Publication: 2019). |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 101647362 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2373-2822 (Electronic) Linking ISSN: 23732822 NLM ISO Abbreviation: eNeuro Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Washington, DC] : Society for Neuroscience, [2014]- |
| مواضيع طبية MeSH: | Neural Inhibition*, Glutamic Acid/*physiology , Neurons/*physiology , Olfactory Bulb/*physiology , Synapses/*physiology, Animals ; Female ; Interneurons/physiology ; Male ; Neurons/ultrastructure ; Olfactory Bulb/ultrastructure ; Olfactory Receptor Neurons/physiology ; Rats, Sprague-Dawley ; Synapses/ultrastructure |
| مستخلص: | Glutamatergic transmission in the brain typically occurs at well-defined synaptic connections, but increasing evidence indicates that neural excitation can also occur through activation of "extrasynaptic" glutamate receptors. Here, we investigated the underlying mechanisms and functional properties of extrasynaptic signals that are part of a feedforward path of information flow in the olfactory bulb. This pathway involves glutamatergic interneurons, external tufted cells (eTCs), that are excited by olfactory sensory neurons (OSNs) and in turn excite output mitral cells (MCs) extrasynaptically. Using pair-cell and triple-cell recordings in rat bulb slices (of either sex), combined with ultrastructural approaches, we first present evidence that eTC-to-MC signaling results from "spillover" of glutamate released at eTC synapses onto GABAergic periglomerular (PG) cells in glomeruli. Thus, feedforward excitation is an indirect result of and must cooccur with activation of inhibitory circuitry. Next, to examine the dynamics of the competing signals, we assayed the relationship between the number of spikes in eTCs and excitation of MCs or PG cells in pair-cell recordings. This showed that extrasynaptic excitation in MCs is very weak due to single spikes but rises sharply and supralinearly with increasing spikes, differing from sublinear behavior for synaptic excitation of PG cells. Similar dynamics leading to a preference for extrasynaptic excitation were also observed during recordings of extrasynaptic and inhibitory currents in response to OSN input of increasing magnitude. The observed alterations in the balance between extrasynaptic excitation and inhibition in glomeruli with stimulus strength could underlie an intraglomerular mechanism for olfactory contrast enhancement. (Copyright © 2019 Gire et al.) |
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| معلومات مُعتمدة: | F31 DC009118 United States DC NIDCD NIH HHS; F31 DC013480 United States DC NIDCD NIH HHS; R01 DC006640 United States DC NIDCD NIH HHS |
| فهرسة مساهمة: | Keywords: GABA; excitation inhibition balance; glutamate; mitral cell; olfactory bulb; transporter |
| المشرفين على المادة: | 3KX376GY7L (Glutamic Acid) |
| تواريخ الأحداث: | Date Created: 20190727 Date Completed: 20200302 Latest Revision: 20200309 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC6709216 |
| DOI: | 10.1523/ENEURO.0247-19.2019 |
| PMID: | 31345999 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2373-2822 |
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| DOI: | 10.1523/ENEURO.0247-19.2019 |