دورية أكاديمية
Hemodialysis performance and anticoagulant activities of PVP-k25 and carboxylic-multiwall nanotube composite blended Polyethersulfone membrane.
| العنوان: | Hemodialysis performance and anticoagulant activities of PVP-k25 and carboxylic-multiwall nanotube composite blended Polyethersulfone membrane. |
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| المؤلفون: | Irfan M; Interdisciplinary Research Centre in Biomedical Materials, COMSATS University Islamabad (CUI), Lahore Campus, Defence Road, Off Raiwind Road, Lahore, Pakistan; Institute of Bioproduct Development, Department of Bioprocess and Polymer Engineering, Faculty of Chemical and Energy Engineering, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia., Irfan M; Department of Chemistry, COMSATS University Islamabad (CUI), Lahore Campus, Defence Road, Off Raiwind Road, Lahore, Pakistan. Electronic address: masooma.uthm@gmail.com., Shah SM; Department of Natural Science and Humanities, RCET, University of Engineering and Technology, Lahore, Pakistan., Baig N; Chemistry Department, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia., Saleh TA; Chemistry Department, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia., Ahmed M; Renacon Pharma Limited, Lahore 54600, Pakistan., Naz G; Department of Physics, Faculty of Science, Baghdad-ul-Jadid Campus, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan., Akhtar N; Interdisciplinary Research Centre in Biomedical Materials, COMSATS University Islamabad (CUI), Lahore Campus, Defence Road, Off Raiwind Road, Lahore, Pakistan., Muhammad N; Interdisciplinary Research Centre in Biomedical Materials, COMSATS University Islamabad (CUI), Lahore Campus, Defence Road, Off Raiwind Road, Lahore, Pakistan., Idris A; Institute of Bioproduct Development, Department of Bioprocess and Polymer Engineering, Faculty of Chemical and Energy Engineering, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia. Electronic address: aniidris@utm.my. |
| المصدر: | Materials science & engineering. C, Materials for biological applications [Mater Sci Eng C Mater Biol Appl] 2019 Oct; Vol. 103, pp. 109769. Date of Electronic Publication: 2019 May 18. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101484109 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-0191 (Electronic) Linking ISSN: 09284931 NLM ISO Abbreviation: Mater Sci Eng C Mater Biol Appl Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier |
| مواضيع طبية MeSH: | Membranes, Artificial*, Anticoagulants/*chemistry , Nanocomposites/*chemistry , Nanotubes/*chemistry , Polymers/*chemistry , Renal Dialysis/*instrumentation , Sulfones/*chemistry, Humans |
| مستخلص: | Non-covalent electrostatic interaction between amide nitrogen and carbonyl carbon of shorter chain length of polyvinylpyrrolidone (PVP-k25) was developed with in-house carboxylic oxidized multiwall carbon nanotubes (O-MWCNT) and then blended with Polyethersulfone (PES) polymer. FTIR analysis was utilized to confirm bonding nature of nano-composites (NCs) of O-MWCNT/PVP-k25 and casting membranes. Non-solvent induces phase separation process developed regular finger-like channels in composite membranes whereas pristine PES exhibited spongy entities as studied by cross sectional analysis report of FESEM. Further, FESEM instrument was also utilized to observe the dispersion of O-MWCNT/PVP based nanocomposite (NCs) with PES and membranes leaching phenomena analysis. Contact angle experiments described 24% improvement of hydrophilic behaviour, leaching ratio of additives was reduced to 1.89%, whereas water flux enhanced up to 6 times. Bovine serum albumin (BSA) and lysozyme based antifouling analysis shown up to 25% improvement, whereas 84% of water flux was regained after protein fouling than pristine PES. Anticoagulant activity was reported by estimating prothrombin, thrombin, plasma re-calcification times and production of fibrinogen cluster with platelets-adhesions photographs and hemolysis experiments. Composite membranes exhibited 3.4 and 3 times better dialysis clearance ratios of urea and creatinine solutes as compared to the raw PES membrane. (Copyright © 2019 Elsevier B.V. All rights reserved.) |
| المشرفين على المادة: | 0 (Anticoagulants) 0 (Membranes, Artificial) 0 (Polymers) 0 (Sulfones) 25667-42-9 (polyether sulfone) |
| تواريخ الأحداث: | Date Created: 20190728 Date Completed: 20191230 Latest Revision: 20191230 |
| رمز التحديث: | 20240513 |
| DOI: | 10.1016/j.msec.2019.109769 |
| PMID: | 31349444 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-0191 |
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| DOI: | 10.1016/j.msec.2019.109769 |